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Dr. Henry Windle

Asst Prof in Molecular Medicine (Clinical Medicine)
TRINITY CENTRE, S J H

Asst Prof in Molecular Medicine (Molecular Medicine Ireland)


  Bacterial pathogenicity   Fusobacterium nucleatum   GASTRIC CANCER   Helicobacter pylori   Host-pathogen interaction   Identification of vaccine candidates   in vitro models of infection   Infectious diseases   Innate and acquired resistance to infection   Innate Immunity   Parasitology and parasitic diseases   Protein chemistry, structure and folding   Proteomics   Vaccines
 Evaluation and Control of Neglected Mucosal Enteric Infections in Childhood
 Evaluation of the carcinogenic potential of Fusobacterium nucleatum
 Development of Clostridium difficile vaccine
 Development of a Helicobacter pylori vaccine

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Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Lynch M, Walsh TA, Marszalowska I, Webb AE, MacAogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE., Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response., BMC Evolutionary Biology, 17, (1), 2017, p90-, Journal Article, PUBLISHED  DOI
Xiaofang Liu, Helena Jahuira, Robert Gilman, Alicia Alva, Lilia Cabrera, Michiko Okamoto, Hang Xu, Dermot Kelleher, Henry Windle, Marco Varela, Manuela Verastegui, Maritza Calderon, Gerardo Sanchez, Vanessa Sarabia, Sarah Ballard, Caryn Bern, Holger Mayta, Jean Crabtree, Vita Cama, Mayuko Saito, and Hitoshi Oshitani , Etiological role and repeated infections of sapovirus among children aged less than two years in a cohort study in a peri-urban community of Peru, Journal of Clinical Microbiology, 54, (6), 2016, p1598-604 , Journal Article, PUBLISHED  DOI
Burrows, A.D., Jurcic, M., Mahon, M.F., Pierrat, S., Roffe, G.W., Windle, H.J., Spencer, J., Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity., Dalton Transactions, 44, (31), 2015, p13814 - 13817, Journal Article, PUBLISHED  DOI
D Jaganath, M Saito, RH Gilman, V Cama, L Cabrera, D Kelleher, H Windle, J Crabtree, W Checkley, First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru, Helicobacter, 2014, Notes: [doi: 10.1111/hel.12130], Journal Article, PUBLISHED  TARA - Full Text
L.E. Collins, M Lynch, I Marszalowska, M. Kristek, K. Rochfort, M. O'Connell, H.J. Windle, D. Kelleher, C.E. Loscher, Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages, Microbes and Infection, 2014, Notes: [PMID 24300042], Journal Article, PUBLISHED  TARA - Full Text  DOI
Saito M, Goel-Apaza S, Espetia S, Velasquez D, Cabrera L, Loli S, Crabtree JE, Black RE, Kosek M, Checkley W, Zimic M, Bern C, Cama V, Gilman RH; The Norovirus Working Group in Peru (Xiao L, Kelleher D, Windle HJ, van Doorn LJ, Varela M, Verastegui M, Calderon M, Alva A, Roman K), Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community., Clin Infect Dis. , 58, (4), 2014, p483 - 491, Journal Article, PUBLISHED  TARA - Full Text  DOI
Queiroz DMM, Harris PR, Sanderson IR, Windle HJ, Walker MM, Rocha AMC, Rocha GA, Carvalho SD, Bittencourt PFS, de Castro LPF, Cillagran A, Serrano C, Kelleher D, Crabtree JE, Iron status and Helicobacter pylori infection in children: an international multi-centered study , PlosOne, 8, (7), 2013, pe6883-, Notes: [PMID: 23861946], Journal Article, PUBLISHED
Sing A, Windle HJ, Cornally D, Ryan B, Henehan GT., A Short-Chain NAD(H)-Dependent Alcohol dehydrogenase (HpSCADH) from Helicobactor pylori: A role in growth under neutral and acidic conditions., The International Journal of Biochemistry & Cell Biology, 45, (7), 2013, p1347-1355 , Notes: [PMID: 23583739], Journal Article, PUBLISHED
Harris PR, Serrano CA, Villagr├ín A, Malker MM, Thomson M, Duarte I, Windle HJ, Crabtree JE , Helicobacter pylori-associated hypochlorohydria in children relates to the development of iron deficiency. , Journal of Clinical Pathology, 66, (4), 2013, p343 - 347, Notes: [PMID: 23268321], Journal Article, PUBLISHED  DOI
Marquez Ruiz JF, Kedziora K, Pigott M, Keogh B, Windle H, Gavin J, Kelleher DP, Gilmer JF., A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib., Bioorg Med Chem Lett, 23, (6), 2013, p1693-8 , Notes: [PMID: 23416011], Journal Article, PUBLISHED  DOI
  

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Infectious pathogens: Helicobacter pylori, Fusobacterium nucleatum, Campylobacter showae, Clostridium difficile