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Professor Thorfinnur Gunnlaugsson

Professor (Chemistry)
BIOMEDICAL SCIENCES INSTITUTE

Professor (CRANN)

Thorfinnur (Thorri) Gunnlaugsson was born in Iceland, where he received his early education in his home town of Hafnarfjörður, before obtaining a B.Sc. in Chemistry from University of Iceland (UI). During his studies at UI he visited the laboratory of Professor A. P. de Silva at Queen's University of Belfast (Northern Ireland), as a research summer student and became fascinated by the world of supramolecular photochemistry, under the magic supervision of 'A.P.'. After receiving a Ph.D. from Queen's University in 1996, under A.P.'s direction, he joined the research group of Professor David Parker at University of Durham (England) as a postdoctoral fellow. Under the guidance of David the world of coordination chemistry and lanthanide luminescence was explored and the excitement continued!

He was appointed as the Kinerton (IPSEN) Lecturer in Medicinal Organic Chemistry at the School of Chemistry, University of Dublin, Trinity College, in October 1998 and a Lecturer in Organic Chemistry in 2000. He was made a Fellow of Trinity College Dublin in 2003. In October 2004 he was appointed as an Associate Professor of Organic Chemistry at the same department amd in 2008 a personal chair and Professor in Chemistry. He was a Visiting Professor at Faculty of Science and Technology- School of Life and Environmental Sciences. Deakin University, Victoria, Australia in 2005. In 2008 he was a visiting Professor in Bordeaux I CNRS in 2008.

  Development of ribonuclease and ribozyme mimics using lanthanide ion complexes   Synthesis & testing of novel anticancer drugs for leukaemia   Synthesis of novel contrast agents for MRI and CT   Synthesis of novel fluorescent and lanthanide luminescient chemosensors for critical care analysis   Synthesis of novel oligonucleosides and modified nucleotides
Details Date
Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
Kotova,Oxana V. O.V., Blasco,Salvador S., Twamley,Brendan B., O'Brien,John E. J.E., Peacock,Robert D. R.D., Kitchen,Jonathan A. J.A., Martínez-Calvo,Miguel M., Gunnlaugsson,Thorfinnur T., The application of chiroptical spectroscopy (circular dichroism) in quantifying binding events in lanthanide directed synthesis of chiral luminescent self-assembly structures, Chemical Science, 6, (1), 2015, p457-471 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Pandurangan K, Kitchen J.A, Blasco S, Boyle E.M, Fitzpatrick B, Feeney M, Kruger P.E, Gunnlaugsson T, Unexpected Self-Sorting Self-Assembly Formation of a [4: 4] Sulfate: Ligand Cage from a Preorganized Tripodal Urea Ligand, Angewandte Chemie International Edition, 54, (15), 2015, p4566-4570 , Journal Article, PUBLISHED  DOI  URL
Byrne J.P, Kitchen J.A, Obrien J.E, Peacock R.D, Gunnlaugsson T, Lanthanide directed self-assembly of highly luminescent supramolecular "peptide" bundles from --amino acid functionalized 2,6-bis(1,2,3-triazol-4-yl)pyridine (btp) ligands, Inorganic Chemistry, 54, (4), 2015, p1426 - 1439, Notes: [Cited By :1 Export Date: 5 August 2015], Journal Article, PUBLISHED  DOI  URL
Fanning A.-M, Plush S.E, Gunnlaugsson T, Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: A study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP), Organic and Biomolecular Chemistry, 13, (20), 2015, p5804 - 5816, Notes: [Export Date: 5 August 2015], Journal Article, PUBLISHED  DOI  URL
Cloonan S.M, Elmes R.B.P, Erby M, Bright S.A, Poynton F.E, Nolan D.E, Quinn S.J, Gunnlaugsson T, Williams D.C, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells, Journal of Medicinal Chemistry, 58, (11), 2015, p4494 - 4505, Notes: [Export Date: 5 August 2015], Journal Article, PUBLISHED  DOI  URL
Martínez-Calvo, M. Kotova, O. Möbius, M.E. Bell, A.P. McCabe, T. Boland, J.J. Gunnlaugsson, T., Healable luminescent self-assembly supramolecular metallogels possessing lanthanide (Eu/Tb) dependent rheological and morphological properties, J. Am. Chem. Soc., 137, (5), 2015, p1983 - 1992, Notes: [Export Date: 11 March 2015], Journal Article, PUBLISHED  DOI  URL
Burke H.M, Gunnlaugsson T, Scanlan E.M, Recent advances in the development of synthetic chemical probes for glycosidase enzymes, Chemical Communications, 51, (53), 2015, p10576 - 10588, Notes: [Export Date: 23 July 2015], Journal Article, PUBLISHED  DOI  URL
Keane P.M, Poynton F.E, Hall J.P, Clark I.P, Sazanovich I.V, Towrie M, Gunnlaugsson T, Quinn S.J, Cardin C.J, Kelly J.M, Enantiomeric conformation controls rate and yield of photoinduced electron transfer in dna sensitized by Ru(II) dipyridophenazine complexes, Journal of Physical Chemistry Letters, 6, (4), 2015, p734 - 738, Journal Article, PUBLISHED  DOI  URL
Keane P.M, Poynton F.E, Hall J.P, Sazanovich I.V, Towrie M, Gunnlaugsson T, Quinn S.J, Cardin C.J, Kelly J.M, Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex, Angewandte Chemie International Edition, 54, (29), 2015, p8364-8368 , Journal Article, PUBLISHED  DOI  URL
Chang C.J, Gunnlaugsson T, James T.D, Imaging agents , Chemical Society Reviews, 44, (14), 2015, p4484-, Journal Article, PUBLISHED  DOI
  

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Award Date
Erskine Fellowship 2009
His research interests are in theareas of supramolecular organic and inorganic chemistry and bio and medicinal chemistry, with emphasis on the recognition and targeting of biologically important ions and molecules.