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Dr. Steven Gray

Clinical Senior Lecturer (Clinical Medicine)

 

Clinical Senior Lecturer (Molecular Medicine Ireland)


Steven Gray graduated from Trinity College Dublin in 1992. He joined the laboratory of Tomas J. Ekstrom at the Karolinska Institute in 1996 and received his PhD in 2000 (Thesis Title: The IGF-axis in liver disease: Modulation of expression by histone deacetylase inhibitors). He moved to the Van Andel Research Institute in Michigan, USA where he continued his studies on the therapeutic potential of histone deacetylase inhibitors in the treatment of cancer. He also spent some time as a visting fellow at Harvard Medical School, Boston working on epigenetic therapies for neurodegenerative disease. Returning to Europe Dr Gray spent some time at the German Cancer Research Centre (DKFZ - Heidelberg), and subsequently moved to Copenhagen to work for Novo Nordisk as part of the research team of Prof Pierre De Meyts at the Hagedorn Research Institute working on epigenetic mechanisms underpinning diabetes pathogenesis. Dr Gray is currently a senior clinical scientist at St James's Hospital in the Deprtment of Clinical Oncology at the Thoraacic Oncology Research Group at St. James's Hospital headed by Dr. Sinead Cuffe and Professor Stephen Finn, and holds an adjunct assistant professorship with the Dept of Clinical Medicine (TCD).
  CANCER   CANCER BIOPSIES   CANCER CELL-LINE   CANCER CELLS   CANCER CHEMOTHERAPY   CANCER CLASSIFICATION   CANCER DEVELOPMENT   CANCER INVASION   CANCER SUSCEPTIBILITY GENE   CANCER-CELLS   CANCERS   CARCINOMA   CARCINOMA CELL-LINES   CARCINOMA, RENAL CELL   CARCINOMA-CELLS   CARCINOMAS   CELL   Cellular Biology   CHROMATIN   Cloning of Cells   Cytogenetics   DNA MARKERS   DNA METHYLATION   EPIDERMAL GROWTH FACTOR RECEPTOR   Epigenetics   GENE EXPRESSION   GENE EXPRESSION ANALYSIS   GENE-EXPRESSION   Genetics   GENOME   Genomes, Genomics   GENOMICS   GROWTH FACTOR RECEPTOR   Histology   Histology, Cytochemistry, Histochemistry   HISTONE   HISTONE DEACETYLASE COMPLEX   INSULIN   INSULIN RESISTANCE   INSULIN-LIKE GROWTH FACTOR I AND II   Life Sciences   METASTASIS   Molecular Biology   Molecular Genetics   Systematic Biology   Tissue Culture   Transcription
Details Date
Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008-2010
Deputy Editor for the Epigenetic Regulators section of the Targeted Proteins database and Epigenetic Regulators section of the CBD Protein Systems journal (launched 2008) 2008 - present
Editorial Board Member The Open Diabetes Journal (Bentham http://www.bentham.org/open/todiaj/EBM.htm) from 2008 2008-2014
Founding Editorial Board Member "Clinical Epigenetics" 2009-present
Member of the Editorial Academy for the "International Journal of Oncology" https://www.spandidos-publications.com/pages/ijo/editorial 2016-present
Editorial Board member "World Journal of Experimental Medicine" (2011-2019) 2011-2019
Editorial Board member "Frontiers in Epigenomics" (Guest Associate Editor & Review Editor) http://www.frontiersin.org/Epigenomics
Editorial Board Member "Frontiers in Systems Physiology" (Review Editor, Systems Biology) http://www.frontiersin.org/systems_physiology
Editorial Board member World Journal of Biological Chemistry Dec 2013
Panel Member: The International Cancer Genome Consortium (workgroup: Renal Cancer) 2008 to present
Grant Reviewer for: Australian National Health and Medical Research Council (NHMRC) (2010, 2012) Austrian Science Fund (2011) Bulgarian Science Foundation (2008) British Lung Foundation (2010) Cancer Research UK (2009) Czech Science Foundation (2012) Cyprus Research Promotion Foundation (2011) The Eli and Edythe Broad Foundation - Broad Medical Research Program (2012) Enterprise Ireland Commercialisation Fund (2005, 2006, 2008) Eureka Eurostars Technical Experts (2015-2016) Fondation contre le Cancer - Belgium (2016) Fondazione Pisa - Italy (2016) France's National Research Agency -ANR [Agence Nationale de la Recherche] (2008, 2011) German Research Foundation (2009) German-Israeli Foundation (2011) HRB Medical Charities Research Group (2008) IASLC (2011, 2012, 2013 on behalf of Professor Kenneth J. O'Byrne)
Grant Reviewer (2): INNOVATION FUND DENMARK (2015). Italian Telethon Foundation (2008) Multiple Sclerosis Society (UK) (2012) The Netherlands Organisation for Scientific Research (NWO) - VENI program (2013) National Science Centre Poland (OPUS) (2015) OeNB Anniversary Fund (Austria) (2014, 2015) OTKA - Hungarian Scientific Research Fund (2014, 2015) Prostate Cancer UK (2014) Wellcome Trust (2009) Swiss Cancer League (2010)
Ad Hoc Journal Reviewer for the following: Acta Neuropathologica, Aging, Antioxidants & Redox Signaling, BBA-Reviews on Cancer, BBA - Gene Regulatory Mechanisms, BMC Medical Genetics, BMC Urology, British Journal of Cancer, British Journal of Clinical Pharmacology, British Journal of Pharmacology, Cancer, Cancer Epidemiology, Cancers (MDPI), Cancer Research, Clinical and Experimental Rheumatology, Cell Biochemistry and Biophysics, Cellular & Molecular Life Sciences, CNS & Neurological Disorders-Drug Targets (CNSND-DT), Clinical Cancer Research, Clinical Lung Cancer, Cytokine, Diabetologia, E-Biomedicine, Epigenetics, European Journal of Cell Biology, European Journal of Pharmacology, Experimental Cell Research, Expert Opinion on Therapeutic Targets, Future Oncology - Epigenomics, Frontiers in Systems Biology, Genes & Cancer, Hormone & Metabolic Research, Inflammation & Allergy - Drug Targets, International Journal of Cancer, International Journal of Immunogenetics
Ad hoc reviewer for various journals (2): Irish Journal of Medical Science, Journal of Cellular & Molecular Medicine, Journal of Experimental and Molecular Pathology, The Journal of Pathology, Journal of Nucleic Acids, Journal of Thoracic Oncology, Life Sciences, Lung Cancer, Mini-Reviews in Medicinal Chemistry, Molecular Cancer Research, Molecular and Cancer Therapeutics, Neurogenetics, Neurological Research, Neuropsychiatric Disease and Treatment, the Open Diabetes Journal, Oncology Reports, OncoTarget, PLoS One, Pharmaceutical Patent Analyst, Pharmacological Research, Pharmacogenomics, Progress in Lipid Research, Translational Research, Trends in Neurosciences, Trends in Molecular Medicine
Invited "ad hoc" contributor to Trends in Genetics Short In Brief Articles section (2001-2002)
Independent Reporter for GenomeBiology (www.genomebiology.com) (2001)
Details Date From Date To
British Thoracic Oncology Group 2005 present
iMiG (International Mesothelioma Interest Group)
ETOP (European Thoracic Oncology Program) - www.etop-eu.org
ToPCaP (Transdisciplinary Prostate Cancer Partnership) - http://topcapteam.org/
Mohamed BM, Boyle NT, Schinwald A, Murer B, Ward R, Mahfoud OK, Rakovich T, Crosbie-Staunton K, Gray SG, Donaldson K, Volkov Y, Prina-Mello A., Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials., Scientific Reports, 8, (679), 2018, Journal Article, PUBLISHED  TARA - Full Text  URL
MacDonagh, L. and Gray, S.G. and Breen, E. and Cuffe, S. and Finn, S.P. and O'Byrne, K.J. and Barr, M.P., BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC, Cancer Letters, 428, 2018, p117-126 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-, Journal Article, PUBLISHED  URL
Singh, A.S. and Heery, R. and Gray, S.G., In silico and in vitro analyses of lncRNAs as potential regulators in the transition from the epithelioid to sarcomatoid histotype of malignant pleural mesothelioma (MPM), International Journal of Molecular Sciences, 19, (5), 2018, p1297-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Letovanec, I. and Finn, S. and Zygoura, P. and Smyth, P. and Soltermann, A. and Bubendorf, L. and Speel, E.-J. and Marchetti, A. and Nonaka, D. and Monkhorst, K. and Hager, H. and Martorell, M. and Sejda, A. and Cheney, R. and Hernandez-Losa, J. and Verbeken, E. and Weder, W. and Savic, S. and Di Lorito, A. and Navarro, A. and Felip, E. and Warth, A. and Baas, P. and Meldgaard, P. and Blackhall, F. and Dingemans, A.-M. and Dienemann, H. and Dziadziuszko, R. and Vansteenkiste, J. and O'Brien, C. and Geiger, T. and Sherlock, J. and Schageman, J. and Dafni, U. and Kammler, R. and Kerr, K. and Thunnissen, E. and Stahel, R. and Peters, S. and Stahel, R.A. and Rosell, R. and Blackhall, F. and Dafni, U. and Kerr, K.M. and Molina, M.Ã . and Bubendorf, L. and Weder, W. and Thunnissen, E. and Peters, S. and Finn, S. and Hiltbrunner, A. and Kammler, R. and Geiger, T. and Marti, N. and Dafni, U. and Tsourti, Z. and Polydoropoulou, V. and Zygoura, P. and Finn, S. and Smyth, P. and O'Brien, C. and Gray, S. and Weder, W. and Soltermann, A. and Opitz, I. and Curioni, A. and Bubendorf, L. and Savic, S. and Lardinois, D. and Dingemans, A.-M. and Speel, E.-J.M. and Ruland, A. and Marchetti, A. and Di Lorito, A. and De Luca, G. and Malatesta, S. and Blackhall, F. and Nonaka, D. and Quinn, A.M. and Franklin, L. and Biernat, W. and Wrona, A. and Rzyman, W. and Jassem, J. and Meldgaard, P. and Hager, H. and Madsen, L.B. and Camps, C. and Martorell, M. and Jantus-Lewintre, E. and Guijarro, R. and Kerr, K.M. and Nicolson, M. and Stevenson, D.A.J. and Mathieson, W. and Baas, P. and de Jong, J. and Monkhorst, K. and Thunnissen, E. and Smit, E. and van Setten, C. and de Langen, J. and Felip, E. and Hernandez-Losa, J. and Sansano, I. and Cheney, R. and Pine, M.B. and Reid, M. and Taylor, E. and Nackaerts, K. and Dooms, C. and Wauters, E. and Van Der Borght, S. and Dienemann, H. and Muley, T. and Warth, A., Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project, Journal of Thoracic Oncology, 13, (3), 2018, pe33-e34 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Quinn Leah, Gray Steven G, Meaney Steve, Finn Stephen, McLoughlin Padraig, Hayes Maria, Extraction and Quantification of Sinapinic Acid from Irish Rapeseed Meal and Assessment of Angiotensin-I Converting Enzyme (ACE-I) Inhibitory Activity , Journal of agricultural and food chemistry , 65 , (32 ), 2017, p6886 - 6892 , Journal Article, PUBLISHED  DOI  URL
Gray, S.G. and Wright, M.C. and Finn, S.P., The "eyes" have it?-intra- and inter-observer reproducibility of the PD-L1 companion diagnostic assay, Translational Cancer Research, 6, 2017, pS1027-S1029 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Greene John, Baird Anne-Marie, Brady Lauren, Lim Marvin, Gray Steven G, McDermott Raymond, Finn Stephen P, Circular RNAs: Biogenesis, Function and Role in Human Diseases , Frontiers in molecular biosciences , 4 , 2017, p38 -, Journal Article, PUBLISHED  DOI  URL
Heery Richard, Finn Stephen P, Cuffe Sinead, Gray Steven G, Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour Drug Resistance and Cancer Stem Cells , Cancers , 9 , (4 ), 2017, p38-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, Gao Y, O'Byrne K.J, Cuffe S, Finn S.P, Gray S.G, Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma, International Journal of Oncology, 50, (3), 2017, p1044 - 1052, Notes: [Export Date: 3 April 2017], Journal Article, PUBLISHED  DOI  URL
  

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Award Date
Invited Speaker EFBIC Diabetes Workshop "Shifting paradigms in diabetes" February 26th 2009
My research mainly involves using epigenetic targeting agents to examine fundamental mechanisms underpinning the regulation of (i) Receptor Tyrosine Kinases (RTKs); (ii) inflammation and (iii) cellular metabolism in thoracic malignancy and to study their potential therapeutic efficacy in the treatment of lung cancer and mesothelioma. Research in my laboratory also tries to understand the role of epigenetics and epigenetic mechanisms underpinning drug resistance in lung cancer and mesothelioma. In addition to the above my research also involves the study of non-coding RNA repertoires (lncRNAs and circRNAs) in lung cancer and mesothelioma for their potential utility as candidate biomarkers for the early prediction of thoracic malignancy, and to study their roles in lung cancer biogenesis and resistance to therapy.