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Dr. Gary Moran

Associate Professor (Dental Science)

My research focuses on the pathogenicity of oral microorganisms, specifically the fungal pathogen Candida albicans and the oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum. Our research involves a combination of molecular genetics, genomics and transcriptomics. We also carry out 16s profiling of the oral microbiome to better understand oral disease. Our research is carried out in the Microbiology laboratory at the Dublin Dental University Hospital, which is on the campus of Trinity College Dublin.
  16s Profiling   antifungal drug resistance   CANDIDA ALBICANS   comparative genomics   fungal morphogenesis   Fusobacterium nucleatum   Genomes, Genomics   in vitro models of infection   microbiome   Molecular Biology   Periodontal disease   Porphyromonas gingivalis   Tissue Culture   transcriptomics   virulence factors
 The TLO genes of Candida albicans
 The Oral Microbiome in Disease
 The role of Tor kinase in filamentation in Candida albicans and Candida dubliniensis
 The Hag genes of Porphyromonas gingivalis

Details Date
President of the Irish Fungal Society 2015-present
Meetings Secretary of the British Society of Medical Mycology 2006-2009
Details Date From Date To
British Society for Medical Mycology 1994 Present
Internation Association of Dental Research (IADR) 1998 Present
American Society for Microbiology 2000 Present
Society for General Microbiology 2007 Present
Dublin Academy of Pathogenomics and Infection Biology 2010 Present
Irish Fungal Scoiety (IFS) 2010 Present
Connolly, E., Millhouse, E., Doyle, R., Culshaw, S., Ramage, G., Moran, G.P., The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation, Molecular Oral Microbiology, 32, (1), 2017, p35 - 47, Journal Article, PUBLISHED  TARA - Full Text
Liu NN, Flanagan PR, Zeng J, Jani NM, Cardenas ME, Moran GP, Köhler JR., Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition., Proceedings of the National Academy of Sciences of the United States of America, 114, (24), 2017, p6346-6351 , Journal Article, PUBLISHED  DOI
Duncan HF, Smith AJ, Fleming GJ, Partridge NC, Shimizu E, Moran GP, Cooper PR, The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity., Journal of cellular physiology, 231, 2016, p798 - 816, Journal Article, PUBLISHED  DOI
Liu Z., Moran G., Sullivan D., MacCallum D., Myers L., Myers L., Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp., PLoS Genetics, 12, (10), 2016, Journal Article, PUBLISHED  DOI
Joanne Mawhinney, Eimear Connolly, Noel Claffey, Gary Moran, Ioannis Polyzois, An in vivo comparison of bacterial microleakage in two dental implant systems: identification of a pathogenic reservoir in dental implants, Acta Odontologica Scandinavica, 73, (3), 2015, p188 - 194, Notes: [Posted online on 11 Nov 2014.], Journal Article, PUBLISHED  TARA - Full Text
Derek J. Sullivan, Judith Berman, Lawrence C. Myers , Gary P. Moran, Telomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?, PLoS Pathogens, 11, (2), 2015, pe1004614-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Caplice, N & Moran G, Candida albicans exhibits enhanced alkaline and temperature induction of Efg1-regulated transcripts relative to Candida dubliniensis, Genomics Data, 6, 2015, p130 - 135, Journal Article, PUBLISHED  TARA - Full Text  DOI
Henry F. Duncan, Anthony J. Smith, Garry J. P. Fleming, Gary P. Moran, Paul R. Cooper, Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points , Genomic Data, 5, 2015, p391 - 393, Journal Article, PUBLISHED  TARA - Full Text
Derek J. Sullivan and Gary P. Moran, Human Pathogenic Fungi: Molecular biology and pathogenic mechanisms, Norfolk, UK, Caister Academic Press, 2014, 1-339-, Book, PUBLISHED
Miajlovic H, Cooke NM, Moran GP, Rogers TR, Smith SG, The response of Extra-intestinal Pathogenic Escherichia coli to human serum reveals a protective role for Rcs-regulated exopolysaccharide colanic acid., Infection and immunity, 82, (1), 2014, p298 - 305, Journal Article, PUBLISHED

Page 1 of 7
GARY P. MORAN, WHY CANDIDA ALBICANS FILAMENTS BETTER THAN ITS BUDDING COUSIN, EUKARYOTIC CELL, 9, (9), 2010, p1299 - 1299, Notes: [Spotlight feature on O'Connor et al. 2010, an "Article of Significant Interest Selected from This Issue by the Editors."], Journal Article, PUBLISHED


Award Date
Irish Division of International Association of Dental Research (IADR) Elida Gibbs Award 1998
EMBO Short-term Fellowship 1997
F.S. Stewart prize (Awarded by Dept. of Microbiology, TCD, for highest grade in moderatorship exam) 1994
My research interests focus on oral microbiology, including: 1) The pathogenic yeast Candida albicans, responsible for oral and systemic fungal infections - I am interested in a telomeric gene family (TLO genes) that encode subunits of the Mediator transcriptional complex. This family of 14 genes regulate virulence traits and we are currently mutating this family using CRISPR-Cas mutagenesis. 2) The oral microbiome: using 16s community profiling identify new disease associations and diagnostic markers in the oral microbiome. Projects include the oral Crohn's disease and Oral cancer microbiomes. 3) Pathogenicity of oral anaerobic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum.