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Dr. Gary Moran

Associate Professor (Dental Science)


My research focuses on the pathogenicity of oral microorganisms, specifically the fungal pathogen Candida albicans and the oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum. Our research involves a combination of molecular genetics, genomics and transcriptomics. We also carry out 16s profiling of the oral microbiome to better understand oral disease. Our research is carried out in the Microbiology laboratory at the Dublin Dental University Hospital, which is on the campus of Trinity College Dublin.
  16s Profiling   antifungal drug resistance   CANDIDA ALBICANS   comparative genomics   fungal morphogenesis   Fusobacterium nucleatum   Genomes, Genomics   in vitro models of infection   microbiome   Molecular Biology   Periodontal disease   Porphyromonas gingivalis   Tissue Culture   transcriptomics   virulence factors
 The TLO genes of Candida albicans
 The Oral Microbiome in Disease
 The role of Tor kinase in filamentation in Candida albicans and Candida dubliniensis
 The Hag genes of Porphyromonas gingivalis

Details Date
President of the Irish Fungal Society 2015-present
Meetings Secretary of the British Society of Medical Mycology 2006-2009
Details Date From Date To
British Society for Medical Mycology 1994 Present
Internation Association of Dental Research (IADR) 1998 Present
American Society for Microbiology 2000 Present
Society for General Microbiology 2007 Present
Dublin Academy of Pathogenomics and Infection Biology 2010 Present
Irish Fungal Scoiety (IFS) 2010 Present
Fungal infections of humans in, editor(s)Kavanagh, K. , Fungi: Biology and applications, third edition, Oxford, John Wiley & Sons Ltd., 2017, pp251 - 274, [Derek J. Sullivan, Gary P. Moran and David C. Coleman], Book Chapter, PUBLISHED  DOI
Elmaghrawy, K., Moran G.P., The oral mucosal microbiome in children with Crohn's disease exhibits reduced biodiversity compared to healthy children, revealed by 16s profiling, Journal of Oral Microbiology, 12th European Oral Microbioloy Workshop, Stokholm, Sweden, 25th-28th May 2017, edited by Georgios Belibasakis , 9, (Supplement 1), Taylor and Francis, 2017, pp1325254 , Conference Paper, PUBLISHED  DOI  URL
Abdrazak Amer, Sheila Galvin, Claire Healy & Gary P. Moran, The microbiome of oral leukoplakia shows enrichment in Fusobacteria and Rothia species, Journal of Oral Microbiology, 12th European Oral Microbiology Workshop, Stockholm, Sweden, May 25th-28th 2017, edited by Georgios Belibasakis , 9, (Supplement 1), Taylor and Francis, 2017, 1325253 , Conference Paper, PUBLISHED  DOI  URL
Connolly, E., Millhouse, E., Doyle, R., Culshaw, S., Ramage, G., Moran, G.P., The Porphyromonas gingivalis hemagglutinins HagB and HagC are major mediators of adhesion and biofilm formation, Molecular Oral Microbiology, 32, (1), 2017, p35 - 47, Journal Article, PUBLISHED  TARA - Full Text
Liu NN, Flanagan PR, Zeng J, Jani NM, Cardenas ME, Moran GP, Köhler JR., Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition., Proceedings of the National Academy of Sciences of the United States of America, 114, (24), 2017, p6346-6351 , Journal Article, PUBLISHED  DOI
Flanagan PR, Liu NN, Fitzpatrick DJ, Hokamp K, Köhler JR, Moran GP., The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation., mSphere, 2, (6), 2017, Journal Article, PUBLISHED  DOI
Amer Abdrazak, Galvin Sheila, Healy Claire M., Moran Gary P., The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia Species, Frontiers in Microbiology, 8, 2017, p2391 , Journal Article, PUBLISHED  DOI  URL
Duncan HF, Smith AJ, Fleming GJP, Partridge NC, Shimizu E, Moran GP, Cooper PR, The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity., Journal of Cellular Physiology, 231, (4), 2016, p798 - 816, Journal Article, PUBLISHED  DOI
Liu Z., Moran G., Sullivan D., MacCallum D., Myers L., Myers L., Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp., PLoS Genetics, 12, (10), 2016, Journal Article, PUBLISHED  DOI
Joanne Mawhinney, Eimear Connolly, Noel Claffey, Gary Moran, Ioannis Polyzois, An in vivo comparison of bacterial microleakage in two dental implant systems: identification of a pathogenic reservoir in dental implants, Acta Odontologica Scandinavica, 73, (3), 2015, p188 - 194, Notes: [Posted online on 11 Nov 2014.], Journal Article, PUBLISHED  TARA - Full Text
  

Page 1 of 8
GARY P. MORAN, WHY CANDIDA ALBICANS FILAMENTS BETTER THAN ITS BUDDING COUSIN, EUKARYOTIC CELL, 9, (9), 2010, p1299 - 1299, Notes: [Spotlight feature on O'Connor et al. 2010, an "Article of Significant Interest Selected from This Issue by the Editors."], Journal Article, PUBLISHED
GARY P. MORAN, MARY ANN JABRA-RIZK, 8TH ASM CONFERENCE ON CANDIDA AND CANDIDIASIS: MOLECULAR TOOLS, MYCOPATHOLOGIA, 162, 2006, p17 - 24, Journal Article, PUBLISHED

  

Award Date
Irish Division of International Association of Dental Research (IADR) Elida Gibbs Award 1998
F.S. Stewart prize (Awarded by Dept. of Microbiology, TCD, for highest grade in moderatorship exam) 1994
EMBO Short-term Fellowship 1997
My research interests focus on oral microbiology, including: 1) The pathogenic yeast Candida albicans, responsible for oral and systemic fungal infections - I am interested in a telomeric gene family (TLO genes) that encode subunits of the Mediator transcriptional complex. This family of 14 genes regulate virulence traits and we are currently mutating this family using CRISPR-Cas mutagenesis. 2) The oral microbiome: using 16s community profiling identify new disease associations and diagnostic markers in the oral microbiome. Projects include the oral Crohn's disease and Oral cancer microbiomes. 3) Pathogenicity of oral anaerobic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum.