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Professor Gwyneth Farrar

Research Professor (Genetics)

  Brittle bone disease   Inherited retinal diseases   Knockout & Transgenic animal models simulating human disease   Neuronal survival mechanisms   Novel approaches to gene therapy
Details Date
Member, DMMC Vascular Biology Principal Investigators, DMMC Principal Investigator leading research on Vascular Biology related projects
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Mansergh FC, Carrigan M, Hokamp K, Farrar GJ, Gene expression changes during retinal development and rod specification, Molecular Vision, 21, 2015, p61 - 87, Journal Article, PUBLISHED  TARA - Full Text  URL  Other
Farrar GJ, Millington-Ward S, Chadderton N, Mansergh FC, Palfi A., Gene therapies for inherited retinal disorders, Visual Neuroscience, 31, ((4-5)), 2014, p289-307 , Journal Article, PUBLISHED  DOI
N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy, Eur J Hum Genet, 21, (1), 2013, p62-68 , Journal Article, PUBLISHED  DOI
Farrar, G.J., Chadderton, N., Kenna, P.F., Millington-Ward, S, Mitochondrial disorders: aetiologies, models systems, and candidate therapies, Trends in Genetics, 2013, p00-00 , Journal Article, IN_PRESS  TARA - Full Text  DOI
Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Jane Farrar G, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy., European journal of human genetics : EJHG, 21, (1), 2013, p62-8 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP, CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression., Developmental cell, 26, (3), 2013, p223-36 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Czekaj M, Haas J, Gebhardt M, Müller-Reichert T, Humphries P, Farrar J, Bartsch U, Ader M, In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes., PloS one, 7, (7), 2012, pe41798 , Journal Article, PUBLISHED
Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798 , Journal Article, PUBLISHED  DOI
Farrar GJ, Millington-Ward S, Chadderton N, Humphries P, Kenna PF, Gene-based therapies for dominantly inherited retinopathies., Gene therapy, 19, (2), 2012, p137-44 , Journal Article, PUBLISHED  DOI
Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M, Kiang AS, Humphries P, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European journal of human genetics : EJHG, 20, (1), 2012, p64-8 , Journal Article, PUBLISHED  DOI

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