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Professor Gwyneth Farrar

Research Professor (Genetics)

 Jane.Farrar@tcd.ie

 3531896 3695/3695

Head of School Genetics & Microbiology (Trinity Inst. of Neurosciences (TCIN))


Research Tags

  Brittle bone disease   Inherited retinal diseases   Knockout & Transgenic animal models simulating human disease   Neuronal survival mechanisms   Novel approaches to gene therapy

Representations

Details Date
Member, DMMC Vascular Biology Principal Investigators, DMMC Principal Investigator leading research on Vascular Biology related projects
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
de Bruijn, S.E. and Rodenburg, K. and Corominas, J. and Ben-Yosef, T. and Reurink, J. and Kremer, H. and Whelan, L. and Plomp, A.S. and Berger, W. and Farrar, G.J. and Ferenc Kovács, à . and Fajardy, I. and Hitti-Malin, R.J. and Weisschuh, N. and Weener, M.E. and Sharon, D. and Pennings, R.J.E. and Haer-Wigman, L. and Hoyng, C.B. and Nelen, M.R. and Vissers, L.E.L.M. and van den Born, L.I. and Gilissen, C. and Cremers, F.P.M. and Hoischen, A. and Neveling, K. and Roosing, S., Optical genome mapping and revisiting short-read genome sequencing data reveal previously overlooked structural variants disrupting retinal diseaseâ^'associated genes, Genetics in Medicine, (100345), 2023, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Chadderton, N. and Palfi, A. and Maloney, D.M. and Carrigan, M. and Finnegan, L.K. and Hanlon, K.S. and Shortall, C. and O†Reilly, M. and Humphries, P. and Cassidy, L. and Kenna, P.F. and Millington-Ward, S. and Farrar, G.J., Optimisation of AAV-NDI1 Significantly Enhances Its Therapeutic Value for Correcting Retinal Mitochondrial Dysfunction, Pharmaceutics, 15, (2), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Millington-Ward, S. and Chadderton, N. and Finnegan, L.K. and Post, I.J.M. and Carrigan, M. and Nixon, R. and Humphries, M.M. and Humphries, P. and Kenna, P.F. and Palfi, A. and Farrar, G.J., RPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models, International Journal of Molecular Sciences, 24, (4), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Whelan, L. and Dockery, A. and Stephenson, K.A.J. and Zhu, J. and KopÄ iÄ , E. and Post, I.J.M. and Khan, M. and Corradi, Z. and Wynne, N. and O†Byrne, J.J. and Duignan, E. and Silvestri, G. and Roosing, S. and Cremers, F.P.M. and Keegan, D.J. and Kenna, P.F. and Farrar, G.J., Detailed analysis of an enriched deep intronic ABCA4 variant in Irish Stargardt disease patients, Scientific Reports, 13, (1), 2023, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Corradi, Z. and Khan, M. and Hitti-Malin, R. and Mishra, K. and Whelan, L. and Cornelis, S.S. and Hoyng, C.B. and KÀmpjÀrvi, K. and Klaver, C.C.W. and Liskova, P. and Stöhr, H. and Weber, B.H.F. and Banfi, S. and Farrar, G.J. and Sharon, D. and Zernant, J. and Allikmets, R. and Dhaenens, C.-M. and Cremers, F.P.M., Targeted sequencing and in vitro splice assays shed light on ABCA4-associated retinopathies missing heritability, Human Genetics and Genomics Advances, 4, (4), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Stephenson, K.A.J. and Whelan, L. and Zhu, J. and Dockery, A. and Wynne, N.C. and Cairns, R.M. and Kirk, C. and Turner, J. and Duignan, E.S. and O†Byrne, J.J. and Silvestri, G. and Kenna, P.F. and Farrar, G.J. and Keegan, D.J., Usher Syndrome on the Island of Ireland: A Genotype-Phenotype Review, Investigative Ophthalmology and Visual Science, 64, (10), 2023, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Reurink, J. and Weisschuh, N. and Garanto, A. and Dockery, A. and van den Born, L.I. and Fajardy, I. and Haer-Wigman, L. and Kohl, S. and Wissinger, B. and Farrar, G.J. and Ben-Yosef, T. and Pfiffner, F.K. and Berger, W. and Weener, M.E. and Dudakova, L. and Liskova, P. and Sharon, D. and Salameh, M. and Offenheim, A. and Heon, E. and Girotto, G. and Gasparini, P. and Morgan, A. and Bergen, A.A. and ten Brink, J.B. and Klaver, C.C.W. and TranebjÊrg, L. and Rendtorff, N.D. and Vermeer, S. and Smits, J.J. and Pennings, R.J.E. and Aben, M. and Oostrik, J. and Astuti, G.D.N. and Corominas Galbany, J. and Kroes, H.Y. and Phan, M. and van Zelst-Stams, W.A.G. and Thiadens, A.A.H.J. and Verheij, J.B.G.M. and van Schooneveld, M.J. and de Bruijn, S.E. and Li, C.H.Z. and Hoyng, C.B. and Gilissen, C. and Vissers, L.E.L.M. and Cremers, F.P.M. and Kremer, H. and van Wijk, E. and Roosing, S., Whole genome sequencing for USH2A-associated disease reveals several pathogenic deep-intronic variants that are amenable to splice correction, Human Genetics and Genomics Advances, 4, (2), 2023, Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Laura K Finnegan, Naomi Chadderton, Paul F Kenna, Arpad Palfi, Michael Carty, Andrew G Bowie, Sophia Millington-Ward, Gwyneth Jane Farrar, SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration, International Journal of Molecular Sciences, 2022, Journal Article, PUBLISHED  TARA - Full Text  URL
Velde, H.M. and Reurink, J. and Held, S. and Li, C.H.Z. and Yzer, S. and Oostrik, J. and Weeda, J. and Haer-Wigman, L. and Yntema, H.G. and Roosing, S. and Pauleikhoff, L. and Lange, C. and Whelan, L. and Dockery, A. and Zhu, J. and Keegan, D.J. and Farrar, G.J. and Kremer, H. and Lanting, C.P. and Damme, M. and Pennings, R.J.E., Usher syndrome type IV: clinically and molecularly confirmed by novel ARSG variants, Human Genetics, 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Stephenson, K.A.J. and Zhu, J. and Dockery, A. and Whelan, L. and Burke, T. and Turner, J. and O†byrne, J.J. and Jane Farrar, G. and Keegan, D.J., Clinical and Genetic Re-Evaluation of Inherited Retinal Degeneration Pedigrees following Initial Negative Findings on Panel-Based Next Generation Sequencing, International Journal of Molecular Sciences, 23, (2), 2022, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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