Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. John Gilmer

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


  ASPIRIN   BINDING   BIOLOGICAL-MEMBRANES   BUTYRYLCHOLINESTERASE   Design, synthesis and testing of specific enzyme inhibitors   ENZYME SUBSTRATE SPECIFICITIES   HOST-GUEST CHEMISTRY   HYDROLYSIS   IMPROVED DELIVERY   Isosorbide-based therapies for Alzheimer's disease   MOLECULAR RECOGNITION   PRODRUG   Pro-drug design for tissue targeting   RECEPTORS   STEROIDS   Thyrotropin-releasing hormone-degrading ectoenzyme inhibitors in the treatment of CNS disorders
 Development of novel aspirin prodrugs
 Probing the interaction of ursodeoxycholic acid with the steroid receptor
 Investigation into highly potent inhibitors of butyrylcholinesterase

Details Date
Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Invitee, Colorectal & GI Cancer Research Group (Proposed), Speculative idea to cluster PI's around collaborative study on Upper GI and Colon Cancers.Deliberately wide selection of surgeons, pathologists and academic researchers based on stated interest or publication in fields of oesophageal or colorectal cancer.To be reviewed/focused by DK/JR/PMacM.Extracted from DMMC Research Database - 8 Nov 2004.
Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
Details Date From Date To
Member of European Federation of Pharmaceutical Scientists
Shane O'Sullivan, John F Gilmer and Carlos Medina, Matrix metalloproteinases in inflammatory bowel disease: an update, Mediators of Inflammation, 2015, p964131-, Review Article, PUBLISHED  TARA - Full Text  DOI
V Voon, C Watson, N Glezeva, M Bermingham, J Wang, R O'Hanlon, J Baugh, K Mc Donald, J Gilmer, M Ledwidge, Doxycycline attenuates matrix metalloproteinase release from inflammatory cells in-vitro and in patients with asymptomatic left ventricular diastolic dysfunction, EUROPEAN JOURNAL OF HEART FAILURE, 16, 2014, pp91-, Conference Paper, PUBLISHED
N Glezeva, M Santos-Martinez, C Watson, K Mcdonald, C Medina, J Gilmer, M Ledwidge, Inhibition of thromboxane pathways in monocytes impedes cell invasiveness, EUROPEAN JOURNAL OF HEART FAILURE, 16, 2014, pp208-209 , Conference Paper, PUBLISHED
Bermingham M, Shanahan MK, O'Connell E, Dawkins I, Miwa S, O'Hanlon R, Gilmer J, McDonald K, Ledwidge M., Aspirin Use In Heart Failure: Is Low Dose Therapy Associated With Mortality And Morbidity Benefits In A Large Community Population?, Circulation: Heart Failure, 7, (2), 2014, p243-250 , Notes: [Featured on Medscape Heartwire: http://www.medscape.com/viewarticle/820323], Journal Article, PUBLISHED  DOI
O'Byrne,Paul Matthew P.M., Williams,Robert P. R.P., Walsh,John J. J.J., Gilmer,John F. J.F., Part two: Evaluation of N-methylbupropion as a potential bupropion prodrug, Pharmaceuticals, 7, (6), 2014, p676-694 , Journal Article, PUBLISHED  DOI
O'Byrne,Paul Matthew P.M., Williams,Robert P. R.P., Walsh,John J. J.J., Gilmer,John F. J.F., Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion. part one: In vitro development, Pharmaceuticals, 7, (5), 2014, p595-620 , Journal Article, PUBLISHED  DOI
Shane O'Sullivan; Carlos Medina; Mark Ledwige; Marek W Radomski; John F Gilmer, Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance NO and MMP-9 interactions, Biochimica et Biophysica Acta - Molecular Cell Research, 1843, (3), 2014, p603-617 , Journal Article, PUBLISHED  DOI
Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C., Mechanisms of platelet-stimulated colon cancer invasion: Role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway, Carcinogenesis, 35, (2), 2014, p324-332 , Journal Article, PUBLISHED  DOI
Simplício AL, Coroadinha AS, Gilmer JF, Lamego J., A methodology for detection and quantification of esterase activity., Methods in Molecular Biology, 984, 2013, p309-19 , Journal Article, PUBLISHED  DOI
Marquez Ruiz JF, Kedziora K, Pigott M, Keogh B, Windle H, Gavin J, Kelleher DP, Gilmer JF., A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib., Bioorg Med Chem Lett, 23, (6), 2013, p1693-8 , Notes: [PMID: 23416011], Journal Article, PUBLISHED  DOI
  

Page 1 of 7
S Etzbach, JJ Salomon, F Májer, MN Mohd Najib, CM Lehr, JF Gilmer, C Ehrhardt, Fluorescence-labelled bile acids as novel tools to measure organic anionic transporting polypeptide (OATP) function, AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Bethesda, MD, 14-16/03/2011, 2011, ppW3020 , Meeting Abstract, PUBLISHED
JJ Salomon, S Etzbach, F Májer, JF Gilmer, CM Lehr, C Ehrhardt, Fluorescent bile acids for the assessment of organic anionic transporting polypeptide (OATP) function, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2119 , Meeting Abstract, PUBLISHED
Gilmer JF, Byrne W, Rynne A, Isosorbide Aspirinate Esters, 1998, WO 9817673 , Patent, PUBLISHED
Gilmer JF, Byrne W, Cardioactive Aspirinates, 1997, WO 9705128, Patent, PUBLISHED

  

Award Date
Visitng Professor in Medicine Chemistry, University of Wurzburg 2014-
Winner, Big Ideas, Enterprise Ireland for Commercialization in The Life Sciences 2010
i) Enzyme inhibitors . Isosorbide-based inhibitors of butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE): synthesis and biochemistry; the role of BuChE in Alzheimer's disease . Rational design of selective covalent inhibitors of COX-2 . Rational design, synthesis and testing of inhibitors for thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) ii) Prodrugs and metabolic hydrolysis . Design and evaluation of aspirin-based antiplatelet agents with reduced gastric toxicity relative to aspirin . Intelligent prodrug carrier systems for targeting corticosteroids to the colon . Exploring metabolic vectors for site specific drug delivery