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Dr. Gavin Davey

Associate Professor (Biochemistry)

Associate Professor (Trinity Inst. of Neurosciences (TCIN))


My research interests are in the areas of Neuroscience and Glycobiology, with specific focus on enzymology, metabolic flux, glycosylation, computational & systems biology. My group researches the molecular and cellular mechanisms that underlie neurodegeneration in the brain, in particular, the role that energy metabolism and bioenergetics play in controlling neuronal function and dysfunction. A major goal is to understand how abnormal mitochondrial dynamics control cell loss in Parkinson's disease and other common brain disorders. My group also has interests in drug development and application of our technologies to the development of next-generation biotherapeutics, including bio- and glyco-engineering of recombinant proteins and therapeutic antibodies.
  Ageing, stroke, dementia   Alzheimer's disease   Anticancer therapies   Apoptosis, molecular control   Biocomputing   Biomarkers of disease   Bioprocesses   Bioreactors   Brain   CANCER   CANCER CELL-LINE   Catecholamine   Cell reprogramming   Computational Biology   Depression   Enzymology and catalysis   GLYCOBIOLOGY   GLYCOSAMINOGLYCANS   In vitro testing, trial methods   Induced pluripotent stem cells   Mathematical modelling   Metabolism and metabolic diseases   MITOCHONDRIAL COMPLEX I   Mitochondrial fission & fusion mechanisms   MITOCHONDRIAL MONOAMINE-OXIDASE   MITOCHONDRIAL-MEMBRANE POTENTIAL   MITOCHONDRION   Molecular Biology   Multiple Sclerosis   Neurochemistry and neuropharmacology   Neurodegeneration   Neuroimmunology   Neuroinformatics   Neuropharmacology   Neuroscience   Neurotoxicity   Oligosaccharide and polysaccharide biochemistry   OXYGEN FREE-RADICALS   PARKINSONS DISEASE   Stem cells   SYNAPSE   SYNAPTOSOMES
 Advanced Biopharmaceutical Technologies
 Training in neurodegeneration, therapeutics intervention and neurorepair
 Glycoengineering Fc/FcγR interactions
 What is the role for ACAD9 as a neurotherapeutic?
 Japan - Ireland International Strategic Cooperation Award

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Details Date
Member of University Council, Trinity College Dublin 2012-2014
Editor EBEC 2008 BBA Bioenergetics 2008
Scientific Advisory Board NIBRT 2013
Language Skill Reading Skill Writing Skill Speaking
Italian Basic Basic Basic
Details Date From Date To
The Biochemical Society, The International Society for Neurochemistry, The Irish Society of Toxicology, The European Society for Neurochemistry, The American Society for Neurochemistry, Neuroscience Ireland, The Irish Network of Neural Stem Cell Investigators (INNSI)
Djikic, T., Martí, Y., Spyrakis, F., (...), Schloss, P., Yelekci, K., Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities, Journal of Biomolecular Structure and Dynamics, 2018, p1-16 , Journal Article, PUBLISHED  DOI
McDonald A.G., Tipton K.F. and Davey G.P., A mechanism for bistability in glycosylation, PLOS Computational Biology, 14, (8), 2018, pe1006348-, Notes: [DOI: 10.1371/journal.pcbi.1006348], Journal Article, PUBLISHED  DOI
McDonald AG, Tipton KF, Davey GP, A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts., PLoS computational biology, 12, (4), 2016, pe1004844 , Journal Article, PUBLISHED  TARA - Full Text  DOI
McDonald AG, Hayes JM, Davey GP, Metabolic flux control in glycosylation., Current opinion in structural biology, 40, 2016, p97-103 , Journal Article, PUBLISHED  DOI
Hayes J.M, Wormald M.R, Rudd P.M, Davey G.P, Fc gamma receptors: Glycobiology and therapeutic prospects, Journal of Inflammation Research, 9, 2016, p209 - 219, Notes: [Export Date: 27 January 2017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352, Journal Article, PUBLISHED  TARA - Full Text  DOI
Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms, Journal of Biological Chemistry, 290, (47), 2015, p28343 - 28352, Journal Article, PUBLISHED  URL
McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026, Journal Article, PUBLISHED  TARA - Full Text  DOI
Hayes JM, Frostell A, Cosgrave EF, Struwe WB, Potter O, Davey GP, Karlsson R, Anneren C and Rudd PM , Fc gamma receptor glycosylation modulates the binding of IgG Glycoforms - a requirement for stable antibody interactions. , Journal of Proteome Research , (13), 2014, p5471 - 5485, Journal Article, PUBLISHED
Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM, Glycosylation and Fc receptors., Current topics in microbiology and immunology, 382, 2014, p165-99 , Journal Article, PUBLISHED  DOI
  

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Reprogramming human dermal fibroblasts for the generation of pluripotent stem cells. in, editor(s)Freshney, R.I. , Culture of Animal Cells, a Manual of Basic Technique and Specialized Applications, John Wiley & Sons , 2010, [Sullivan S, Davey GP ], Book Chapter, PUBLISHED
McDonald AG, Tipton KF and Davey GP, Mathematical modelling of metabolism., The Biochemist, 2009, Journal Article, PUBLISHED

  

Award Date
International Conference of Radiation Research conference lecture 1999
European Union Marie Curie Return Grant 1997
European Union Human Capital and Mobility Fellowship 1994-1996
. Metabolism, Systems Biology & Enzymology: Flux control analysis; mathematical models of cellular metabolic networks and N- and O-linked glycosylation networks in cancer cells, immune cells and neurons; NMR metabolomics. . Glycosylation and Bioprocessing: Glycosyltransferases; CHO cells & recombinant biotherapeutics; metabolism and CHO cell performance; controlling N- and O-linked glycosylation in CHO cells; glycosylation & Fc- FcγR interactions. . Mitochondrial dysfunction: Mitochondrial dysfunction in ageing brain; supercomplex structures; ETC post-translational modifications; neurodegeneration models. . Neuroprotection and Neuroregeneration: Neuronal cell surface glycome; Fc-FcγR interactions in the brain; control of mitochondrial dynamics & Parkinson's disease; stem cell regeneration; drug development; biomarker discovery. . In silico drug design: Computational modelling of cell transporters & and drug design.