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Dr. Frederick Sheedy

Ussher Assistant Professor (Biochemistry)

 


I recently established my independent research group within the School of Biochemistry & Immunology at Trinity College, Dublin (TCD), Ireland, examining macrophage function in health and disease. I pioneered miRNA research in the field of innate immunity during my graduate studies in the O'Neill Lab, resulting in a Nature Immunology first author publication and this emerging field was highlighted by a Nature Reviews Immunology article, which I co-wrote. I obtained a postdoctoral fellowship from the American Heart Association to study the molecular mechanisms of inflammation in disease at NYU. This transformative work was published in Nature Immunology and alongside my recent work on tuberculosis, funded by a Starting Investigator grant from Science Foundation Ireland, fueled my interest in macrophage-driven disease. My recent work published in Cell Reports, J Immunology and AJRCMB (as last author), has uncovered the regulation of anti-microbial function by metabolism and through multiple industrial partnerships with local food companies , I have begun to examine the potential for β-glucan training of immunity. I aim to use this to consolidate my research in the emerging area of innate immune training and how this can improve resistance to infection.
  Bacteriology and bacterial pathogenesis   Host, Pathogen interactions   Immune system   Immunochemistry and immunogenetics   Immunodeficiency diseases   Immunology, Immunotherapy   Infectious diseases   Innate immunology   Lipid metabolism   Metabolism and metabolic diseases   Molecular Biology   Regulatory methods of gene expression   RNA processing, stability and degradation   Tumour immunology and immunotherapy   Vaccines   Vascular Biology, Thrombosis
 Mushroom digestion as a model to re-define gut-immune system cross-talk via Innate Immune Training
 Wellmune trains monocytes to increase innate immune memory & resistance
  Targeting microRNA to drive a successful host response to Mycobacterium tuberculosis
 Measuring monocyte function as a marker of cardiovascular disease and immune activation
 Metabolic control of tumor associated macrophage reprogramming by microRNA-21

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Details Date From Date To
Irish Society of Immunology 2014 2020
American Heart Association - ATVB Council 2010 2013
Trinity Biochemical Society 2005 2020
Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4 , Journal Article, PUBLISHED
Gleeson LE, O'Leary SM, Ryan D, McLaughlin AM, Sheedy FJ, Keane JM., Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection., American journal of respiratory cell and molecular biology, 2018, Journal Article, PUBLISHED  DOI
Hackett, E.E., Sheedy, F.J., MiR-21 alters circulating Treg function in vascular disease-hope for restoring immunoregulatory responses in atherosclerosis?, Annals of Translational Medicine, 5, (1), 2017, Journal Article, PUBLISHED
Ni Cheallaigh Cliona, Sheedy Frederick J., Shields Up: Systemic Protection Provided by microRNA-21 During Sepsis?, 45 , (7 ), 2017, Journal Article, PUBLISHED  URL
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379, Journal Article, PUBLISHED  TARA - Full Text  URL
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Gleeson, L.E., Sheedy, F.J., Metabolic reprogramming & inflammation: Fuelling the host response to pathogens, Seminars in Immunology, 28, (5), 2016, p450-468 , Journal Article, PUBLISHED
Ouimet, M., Koster, S., Sakowski, E., Ramkhelawon, B., Van Solingen, C., Oldebeken, S., Karunakaran, D., Portal-Celhay, C., Sheedy, F.J., Ray, T.D., Cecchini, K., Zamore, P.D., Rayner, K.J., Marcel, Y.L., Philips, J.A., Moore, K.J., Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism, Nature Immunology, 17, (6), 2016, p677-686 , Journal Article, PUBLISHED
Ouimet, M., Ediriweera, H.N., Mahesh Gundra, U., Sheedy, F.J., Ramkhelawon, B., Hutchison, S.B., Rinehold, K., Van Solingen, C., Fullerton, M.D., Cecchini, K., Rayner, K.J., Steinberg, G.R., Zamore, P.D., Fisher, E.A., Loke, P., Moore, K.J., MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis, Journal of Clinical Investigation, 125, (12), 2015, p4334-4348 , Journal Article, PUBLISHED
Sheedy, F.J., Turning 21: Induction of miR-21 as a key switch in the inflammatory response, Frontiers in Immunology, 6, (JAN), 2015, Journal Article, PUBLISHED  TARA - Full Text
  

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Award Date
Provost PhD Award 2020
Trinity Innovation Awards - short-listed in Industry Engagement 2019
Irish Heart Foundation Stroke Prevention Research Bursary Award 02/2017
Senior Research Fellow, Trinity College Dublin 01/2014
Researcher of the Year, Trinity Institute of Molecular Medicine 11/2013
Highest achieving undergraduate student in first year of novel BSc Genetics, UCC 06/2004