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Professor Thomas Frodl

Stokes Professor (Psychiatry)
TALLAGHT HOSPITAL

Stokes Professor (Trinity Inst. of Neurosciences (TCIN))

Positions and Employment 1992-1998 Study of Medicine at Free University of Berlin and University of Munich 1998-2003 Registrar and Senior Registrar in Psychiatry, Dept. Of Psychiatry and Psychotherapy, University Munich, Germany 2003-2004 Senior Registrar in Neurology, Dept. of Neurology, University of Munich 2005-2008 Consultant in General Psychiatry, Dept. of Psychiatry, University of Munich 2004-2008 Senior Lecturer / Assistant Professor, Dept. of Psychiatry, University of Munich 2008- Professor & Chair of Integrated Neuroimaging, Psychiatry, Trinity College, University of Dublin
  ADHD   Ageing, memory and other cognitive processes   Alzheimer's disease   Anatomy   Antidepressants   Attention Deficit Hyperactivity Disorder (ADHD)   Bipolar disorder   Brain theory,brain mapping   Childhood and mental health   Dementia   Depression   Development, prevention and treatment of mental disease or disorder   Developmental and mental disorders   DNA transcription and translation   Emotional, behavioural and cognitive disorders   Exercise and cystic fibrosis   Health informatics   Human genetics   Learning disabilities   Mood and Anxiety Disorders   Neurobiology   Neurodegeneration   Neurodevelopmental Disorders   Neuroendocrine Immunology   Neurogenetics   Neuroimaging   Neurophysiology   Neuroplasticity   Neuropsychology   Personal Therapy   Psychiatric Disorders   Psychiatric genetics   PSYCHIATRIC PATIENTS   PSYCHIATRIC PHENOMENA   PSYCHIATRIC RESEARCH   PSYCHIATRIC SERVICE   PSYCHIATRIC-DISORDER   PSYCHIATRIC-DISORDERS   PSYCHIATRIC-INPATIENTS   PSYCHIATRIC-SYMPTOMS   Psychiatry   Psychotherapy   Rehabilitation   RNA processing, stability and degradation   Schizophrenia
 Brain Imaging Return to Health, rebirth
 Clinical and biological outcome of adults with childhood diagnosed Attention Deficit/Hyperactivity Disorder (ADHD)
 Functional as well as structural brain connectivity and epigenetic changes in major depressive disorder associated with remission and persistence of symptoms over a 5 year course
 SFI Stokes Professorship
 Neural and stress correlates of resilience in an exercise-cognitive-behavioural programme

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Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Medium Medium
German Fluent Fluent Fluent
Details Date From Date To
Irish College of Psychiatrists 1/1/2010
Medical Council, Specialist Register 8/2008
Centre for Integrative Psychotherapy (CIP), Munich 1/1/2008
German Society for Neuropsychopharmacology 2003
Frodl, T, Gene x Environment Interaction in depression, NIAS, The Netherlands Institute of Advanced Sicence , Utrecht, Januar, 2014, NIAS, Invited Talk, PUBLISHED
Frodl, T, Gene x Environment Interaction in Depression, Bunnik Symposium, Utrecht, January, 2014, Lundbeck, Invited Talk, PUBLISHED
Frodl T, Skokauskas N, Frey EM, Morris D, Gill M, Carballedo A, BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields., Human brain mapping, 2014, Journal Article, PUBLISHED
Ugwu ID, Amico F, Carballedo A, Fagan AJ, Frodl T, Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study., Brain structure & function, 2014, Journal Article, PUBLISHED
Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CR, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJ, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HH, Hagenaars S, Hajek T, Hall GB, Hall J, Hardy J, Hartman CA, Hass J, Hatton SN, Haukvik UK, Hegenscheid K, Heinz A, Hickie IB, Ho BC, Hoehn D, Hoekstra PJ, Hollinshead M, Holmes AJ, Homuth G, Hoogman M, Hong LE, Hosten N, Hottenga JJ, Hulshoff Pol HE, Hwang KS, Jack CR, Jenkinson M, Johnston C, Jönsson EG, Kahn RS, Kasperaviciute D, Kelly S, Kim S, Kochunov P, Koenders L, Krämer B, Kwok JB, Lagopoulos J, Laje G, Landen M, Landman BA, Lauriello J, Lawrie SM, Lee PH, Le Hellard S, Lemaître H, Leonardo CD, Li CS, Liberg B, Liewald DC, Liu X, Lopez LM, Loth E, Lourdusamy A, Luciano M, Macciardi F, Machielsen MW, Macqueen GM, Malt UF, Mandl R, Manoach DS, Martinot JL, Matarin M, Mather KA, Mattheisen M, Mattingsdal M, Meyer-Lindenberg A, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meisenzahl E, Melle I, Milaneschi Y, Mohnke S, Montgomery GW, Morris DW, Moses EK, Mueller BA, Muñoz Maniega S, Mühleisen TW, Müller-Myhsok B, Mwangi B, Nauck M, Nho K, Nichols TE, Nilsson LG, Nugent AC, Nyberg L, Olvera RL, Oosterlaan J, Ophoff RA, Pandolfo M, Papalampropoulou-Tsiridou M, Papmeyer M, Paus T, Pausova Z, Pearlson GD, Penninx BW, Peterson CP, Pfennig A, Phillips M, Pike GB, Poline JB, Potkin SG, Pütz B, Ramasamy A, Rasmussen J, Rietschel M, Rijpkema M, Risacher SL, Roffman JL, Roiz-Santiañez R, Romanczuk-Seiferth N, Rose EJ, Royle NA, Rujescu D, Ryten M, Sachdev PS, Salami A, Satterthwaite TD, Savitz J, Saykin AJ, Scanlon C, Schmaal L, Schnack HG, Schork AJ, Schulz SC, Schür R, Seidman L, Shen L, Shoemaker JM, Simmons A, Sisodiya SM, Smith C, Smoller JW, Soares JC, Sponheim SR, Sprooten E, Starr JM, Steen VM, Strakowski S, Strike L, Sussmann J, Sämann PG, Teumer A, Toga AW, Tordesillas-Gutierrez D, Trabzuni D, Trost S, Turner J, Van den Heuvel M, van der Wee NJ, van Eijk K, van Erp TG, van Haren NE, van 't Ent D, van Tol MJ, Valdés Hernández MC, Veltman DJ, Versace A, Völzke H, Walker R, Walter H, Wang L, Wardlaw JM, Weale ME, Weiner MW, Wen W, Westlye LT, Whalley HC, Whelan CD, White T, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Zilles D, Zwiers MP, Thalamuthu A, Schofield PR, Freimer NB, Lawrence NS, Drevets W, The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data., Brain imaging and behavior, 8, (2), 2014, p153-82 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Frodl T, Skokauskas N, Neuroimaging of externalizing behaviors and borderline traits., Biological psychiatry, 75, (1), 2014, p7-8 , Journal Article, PUBLISHED
Chaney A, Carballedo A, Amico F, Fagan A, Skokauskas N, Meaney J, Frodl T, Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants., Journal of psychiatry & neuroscience : JPN, 39, (1), 2014, p50 - 59, Journal Article, PUBLISHED
McCarthy H, Skokauskas N, Frodl T, Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: a meta-analysis., Psychological medicine, 44, (4), 2014, p869-80 , Journal Article, PUBLISHED
Frodl, T, Gene x Environment Interaction on brain structure and function, Calgary Symposium, Calgary, Canada, June, 2013, University of Calgary, Invited Talk, PUBLISHED
Frodl, T, Neuroimaging in Depression, Seminar, Edinburgh, May, 2013, Invited Talk, PUBLISHED
  

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Frodl, T, Emotion, Empathy and Neuroimaging, Seminar, Innsbruck, May, 2013, Invited Talk, PUBLISHED
Thomas Frodl, Yolande Ferguson, Andrew Fagan, Danusia Lisiecka, Angela Carballedo, Ian Daly, James Meaney & Dermot Kelleher, Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?, 2010, Working Paper, IN_PRESS

  

Award Date
Hormosan Research Award of the German Society of Psychiatry, Psychotherapy and Neurology 2005
Association of European Psychiatrists Congress Price 2005
Organon Award of the Society of Biological Psychiatry 2006
My research focus is within 3 main areas: A. Translational research starting from experimental studies in mice or rats and applying new and established neuroimaging techniques or blood markers (like genetic or functional genetic biomarkers) to clinical populations in order to gain inside into the pathophysiology of disease, vulnerability and resilience. It will be important to explore the effects of stress and of peripheral stress blood markers on brain function and structure and to examine the impact of functional genetics, e.g. epigenetics on brain structure and function. In the past I carried out multi/disciplinary studies in patients with major depression and ADHD. Currently, we are carrying an HRB funded project on biomarkers of adult ADHD patients longitudinally followed from childhood to adulthood. Recently, I received major funding for translational research within the area of stress, neuroplasticity and ageing within the EU-multi-institutional training program - 4.3 MIO in total and about 730.000 Euro personal funding. This network program is prestigious apart for the science also in terms of close working relationships with other universities like Turku (Finland), Lund (Sweden), Nottingham (UK), Brussels (Belgium) and Magdeburg (Germany). 2. Clinical research programs implementing biological methods: Identifying fundamental brain network alterations in psychiatric disorders such as depression, ADHD, schizophrenia and dementia using neuroimaging and neurophysiological methods that further can be applied to clinical research programs in order to examine biological underpinnings of therapy response and finding markers for therapy response and differential diagnosis. An open question is for example to explore the role that gene x environmental interactions play in therapy response and how this information could be used for therapy guidance. Currently, my research group is carrying out trials on exercise in healthy controls and in patients with major depression. I have a written proposal for a clinical program using neuroimaging and blood investigations as primary outcome measures in a sample of patients receiving either psychotherapy or optimized pharmacotherapy. Moreover, I run several clinical trials that included the use of neuroimaging techniques like fMRI and Single Photon Emission Tomography in Munich. 3. Health service research: Still there is strong need to explore which clinical programs within a service deliver enduring quality for the health of a population and thus also have benefits on the longer term for the resources of a service, e.g. by saving money that can be used then for novel developments of clinical programs. For example it is still a matter of debate whether early intervention or home treatment have enduring benefits or whether they just reduce the need for inpatient therapies. Thus I will be very keen to investigate the clinical and wider health outcomes of programs such as early intervention for psychosis, CBT for psychosis, suicide prevention, crisis intervention, home treatment within naturalistic and clinical trials. A broader view is also to compare the efficacy of the modern Dublin mental health service compared to for example a more traditional health service in Germany. At present I have experience in carrying out health service research in the area of learning disability and have experience with measures for quality control and risk assessment as well as prevention of risks for staff and patients within a service.