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Professor Fergal O'Brien

Adjunct Associate Professor (Trinity Centre for Bioengineering)

 

Adjunct Associate Professor (Mechanical & Manuf. Eng)


Prof. Fergal O'Brien is a graduate in mechanical engineering from Trinity College, Dublin. He subsequently carried out research for his PhD in the area of bone biomechanics between RCSI and TCD (awarded 2001). Following his PhD, he was a Fulbright Scholar and carried out research in orthopaedic tissue engineering at Massachusetts Institute of Technology in collaboration with in Harvard Medical School. In May, 2003 he left the US to take up a position as Lecturer in Anatomy in RCSI. He has subsequently developed one of the largest tissue engineering/regenerative medicine groups in Ireland and has been involved in the acquisition of over EUR12 million in grant funding, has published over 100 articles in peer-reviewed international journals, filed 6 patents and graduated 16 PhD students since 2003. He has been awarded a number of scientific honours including a Fulbright Scholarship (2001), New Investigator Recognition Award by the Orthopaedic Research Society (2002), Science Foundation Ireland, President of Ireland Young Researcher Award (2004), Engineers Ireland Chartered Engineer of the Year (2005) and in 2009, a European Research Council (ERC) Investigator Award (Eur 2 million). He is a Chartered Engineer and Fellow of the Institution of Engineers of Ireland (Engineers Ireland). He has served as a reviewer for over 50 scientific journals and a grant reviewer for agencies in Europe, Australia, Canada and USA. He is currently Treasurer of the Biomedical Division of Engineers Ireland, Committee Member of the Bioengineering Section of the Royal Academy of Medicine in Ireland, Editorial Consultant for the Journal of Biomechanics and Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials. For more information and current news on the Bone & Tissue Engineering Research Group in RCSI: www.rcsi.ie/boneresearch. Office Contact Details: Email: fjobrien@rcsi.ie. Tel. 01-4022149, Fax. 01-4022355
  Animal Model   BIODEGRADABLE IMPLANT   BIODEGRADABLE POLYMERS   Bioengineering   Biological Engineering   Biological Modeling   Biological Polymers   Biomaterials   Biomechanics   Biomechanics, Biomedical Engineering   Biomedical Engineering   Biomedical Research, Multidisciplinary   Biopolymeric Materials   Bioreactors   Biotechnology   Bone   Bone Diseases   BONE GROWTH AND DEVELOPMENT   BONE LOSS   BONE MASS   bone microdamage   BONE REGENERATION   bone remodelling and repair   BONE TURNOVER   BONE-DENSITY   BONE-RESORPTION   CARTILAGE   Cell and tissue development   Cell and tissue maintenance, repair and ageing   Cell signalling, proliferation & differentiation   Cellular Biology   Chemicals/Materials   Composite materials   Engineering underpinning biomedicine   Fatigue/Fracture   FRACTURES   Materials technology, engineering   Maxillofacial surgery   Mechanical Engineering   Mechanical Properties, Materials   Medical Devices   Medical Devices Engineering   Medical Sciences, Research   Musculoskeletal System   Orthopaedic surgery   Orthopedics   osteoporosis   SCAFFOLD   Stem Cell   Stem Cell Biology   TISSUE ADAPTATION   Tissue Culture   tissue engineering
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Details Date
See here: http://www.rcsi.ie/researchdb/research_piprofile.jsp?uid=62&pip=team#themes
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Details Date From Date To
Member of the Institution of Engineers of Ireland Chartered Engineer, 2005 1996 present
Member of the European Society for Engineering and Medicine Council Member, 2004 Newsletter Editor, 2004 Website Editor, 2004 2002 present
Member of the European Society of Biomechanics 2002 present
Member of the American Society for Bone and Mineral Research 2005 present
Member of the Anatomical Society of Great Britain and Ireland 2003 present
Member of the Irish Fulbright Alumni Association 2003 present
Murphy, Ciara M. Schindeler, Aaron Gleeson, John P. Yu, Nicole Y. C. Cantrill, Laurence C. Mikulec, Kathy Peacock, Lauren O'Brien, Fergal J. Little, David G., A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates, Acta Biomaterialia, 2014, Journal Article, PUBLISHED  TARA - Full Text
Levingstone, Tanya J. Matsiko, Amos Dickson, Glenn R. O'Brien, Fergal J. Gleeson, John P., A biomimetic multi-layered collagen-based scaffold for osteochondral repair, Acta Biomaterialia, 2014, Journal Article, PUBLISHED  TARA - Full Text
Amato G, O'Brien F, Ghosh B, Simms CK, Multibody modelling of a TB31 and a TB32 crash test with vertical portable concrete barriers: Model verification and sensitivity analysis, IMechE Journal of Multibody Dynamics, 227, (3), 2013, p245-260 , Journal Article, PUBLISHED  DOI
Amato G, O'Brien F, Ghosh B, Williams, G, Simms CK, Multibody modelling of gabion beams for impact applications, Journal of Crashworthiness, 18, (3), 2013, 237-250 , Journal Article, PUBLISHED  DOI
Amato G, O'Brien F, Ghosh B, Williams, G, Simms CK, A Scaling Method for Modelling the Crashworthiness of Novel Roadside Barriers, Journal of Crashworthiness, 18, (1), 2013, p93-102 , Journal Article, PUBLISHED  DOI
Erica G. Tierney, Garry P. Duffy, Alan J. Hibbitts, Sally-Ann Cryan, Fergal J. O'Brien, The Development of Non-Viral Gene-Activated Matrices for Bone Regeneration Using Polyethyleneimine (PEI) and Collagen-Based Scaffolds, Journal of Controlled Release, 2012, Journal Article, IN_PRESS  TARA - Full Text
Ciara M. Murphy, Amos Matsiko, Matthew G. Haugh, John P. Gleeson, Fergal J. O'Brien, Mesenchymal stem cell fate is regulated by the composition and mechanical properties of Collagen-Glycosaminoglycan scaffolds, Journal of the Mechanical Behavior of Biomedical Materials, 2012, Journal Article, IN_PRESS  TARA - Full Text
Eric Farrell, Sanne Both, Kathrin I Ödorfer, Wendy Koevoet, Nicole Kops, Fergal J O'Brien, Robert J Baatenburg de Jong, Jan A Verhaar, Vincent Cuijpers, John Jansen, Reinhold G Erben, Gerjo JVM van Osch, In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells, BMC Musculoskeletal Disorders, 12, (31), 2011, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Fergal J O'Brien, Biomaterials and scaffolds for tissue engineering, MATERIALS TODAY, 14, (3), 2011, p88-95 , Journal Article, PUBLISHED  TARA - Full Text
Haugh MG, Murphy CM, McKiernan RC, Altenbuchner C, O'Brien FJ, Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds., Tissue engineering. Part A, 17, (9-10), 2011, p1201-8 , Journal Article, PUBLISHED  TARA - Full Text
  

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Proceedings of Fifth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine of Ireland , Dublin, Trinity College , [eds.], 1999, Editorial Board, PUBLISHED

  

Award Date
Engineers Ireland, Chartered Engineer of the Year Award 2005
Science Foundation Ireland, President of Ireland Young Researcher Award 2004
New Investigator Recognition Award for Outstanding Scientific Paper, 48th Annual Meeting of the Orthopaedic Research Society, Dallas, Texas 2002
Fulbright Scholarship 2001
Co-author on paper which won Genzyme Award for Excellence in Cartilage Research 2007, ?Tracking bone marrow stromal cells with iron oxide labelling and its effects on multilineage differentiation potential?, International Cartilage Repair Society 2007
Appointed as a Subject Editor (Tissue Engineering) for the Journal of the Mechanical Behavior of Biomedical Materials., Journal of the Mechanical Behavior of Biomedical Materials (Elsevier) 2007
Appointed to Editorial Board of Journal of Biomechanics. 2009
Starting Independent Researcher Grant by the European Research Council (2million Euro) 2009
Regenerative medicine: tissue engineering of bone and cartilage, scaffolds, bioreactors and stem cell biology. Mechanical behaviour of bone, bone remodelling, bone quality and osteoporosis.