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Dr. Jean Fletcher

Associate Prof in Translational Immunolo (Biochemistry)

 fletchj@tcd.ie

 3531896 4437

Associate Prof in Translational Immunolo (Clinical Medicine)


Research Tags

  Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Autoimmunity   HIDRADENITIS SUPPURATIVA   IMMUNE FUNCTION   Immune regulation   Immune system   IMMUNE-RESPONSE   IMMUNITY   Immunoassays   IMMUNOLOGICAL MECHANISMS   IMMUNOLOGICAL REGULATION   Immunology   Immunology, Immunotherapy   Immunotherapy   Multiple Sclerosis   MULTIPLE-SCLEROSIS   Regulatory T cells   Rheumatology and rheumatological disorders   T cells   Th17 cells   Tumour Biology/ Immunology

Research Projects

 Dysregulation of pathogenic T cells in multiple sclerosis
 The role of CD39+ regulatory T cells in autoimmune disease

Languages

Language Skill Reading Skill Writing Skill Speaking
Afrikaans Basic Basic Basic
English Fluent Fluent Fluent

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
British Society for Immunology 2000 present
Irish Society for Immunology 2005 present
Biochemical Society 2005 present
Petrasca A, Hambly R, Molloy O, Kearns S, Moran B, Smith CM, Hughes R, O'Donnell M, Zaborowski A, Winter D, Fletcher JM, Kirby B, Malara A., Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa., PloS one, 18, (2), 2023, pe0281688 , Journal Article, PUBLISHED  DOI
Barker BE, Hanlon MM, Marzaioli V, Smith CM, Cunningham CC, Fletcher JM, Veale DJ, Fearon U, Canavan M., The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis., Frontiers in medicine, 10, 2023, p1029021 , Journal Article, PUBLISHED  DOI
Smith CM, Hambly R, Gatault S, Iglesias-Martinez LF, Kearns S, Rea H, Marasigan V, Lynam-Loane K, Kirthi S, Hughes R, Fletcher JM, Kolch W, Kirby B., B-cell-derived transforming growth factor-ß may drive the activation of inflammatory macrophages and contribute to scarring in hidradenitis suppurativa., The British journal of dermatology, 188, (2), 2023, p290-310 , Journal Article, PUBLISHED  DOI
O'Connor, C., Jordan, K., Vagg, T., Murphy, C.E., Barry, D.B., Toulouse, A., Flecther, J., Downer, E.J. , Animated teaching improves student learning of human gastrulation and neurulation., Annals of Anatomy, in press, 2023, Journal Article, PUBLISHED  DOI  URL
Hambly R, Gatault S, Smith CM, Iglesias-Martinez LF, Kearns S, Rea H, Marasigan V, Lynam-Loane K, Kirthi S, Hughes R, Fletcher JM, Kolch W, Kirby B., B-cell and complement signature in severe hidradenitis suppurativa that does not respond to adalimumab., The British journal of dermatology, 188, (1), 2023, p52-63 , Journal Article, PUBLISHED  DOI
Gaynor N, Blanco A, Madden SF, Moran B, Fletcher JM, Kaukonen D, Ramírez JS, Eustace AJ, McDermott MSJ, Canonici A, Toomey S, Teiserskiene A, Hennessy BT, O'Donovan N, Crown J, Collins DM., Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy., British journal of cancer, 129, (6), 2023, p1022-1031 , Journal Article, PUBLISHED  DOI
Moran, B. and Smith, C.M. and Zaborowski, A. and Ryan, M. and Karman, J. and Dunstan, R.W. and Smith, K.M. and Hambly, R. and Musilova, J. and Petrasca, A. and Fabre, A. and O'Donnell, M. and Hokamp, K. and Mills, K.H.G. and Housley, W.J. and Winter, D.C. and Kirby, B. and Fletcher, J.M., Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin, The British journal of dermatology, 189, (4), 2023, p447-458 , Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Hambly R, Kearney N, Hughes R, Fletcher JM, Kirby B., Metformin Treatment of Hidradenitis Suppurativa: Effect on Metabolic Parameters, Inflammation, Cardiovascular Risk Biomarkers, and Immune Mediators., International journal of molecular sciences, 24, (8), 2023, p6969 , Journal Article, PUBLISHED  DOI
Petrasca A, Hambly R, Kearney N, Smith CM, Pender EK, Mac Mahon J, O'Rourke AM, Ismaiel M, Boland PA, Almeida JP, Kennedy C, Zaborowski A, Murphy S, Winter D, Kirby B, Fletcher JM., Metformin has anti-inflammatory effects and induces immunometabolic reprogramming via multiple mechanisms in hidradenitis suppurativa., The British journal of dermatology, 189, (6), 2023, p730-740 , Journal Article, PUBLISHED  DOI
Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade SM, Hanlon M, Cunningham C, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao LY, Monaghan MG, Nagpal S, Veale DJ, Fearon U., Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis., Annals of the rheumatic diseases, 2022, pannrheumdis-2021-221761 , Journal Article, PUBLISHED  DOI
  

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Awards and Honours

Award Date
First prize for the best oral presentation at the Irish Society for Immunology 2008 Annual Congress. 2008
Fellow of Trinity College Dublin 2021

Research Interests

Description Of Research Interests

Research interests are focused on immune regulation in human disease. In a healthy immune system there is a balance between the pro-inflammatory responses necessary to fight infection and regulatory responses which keep these in check and maintain tolerance. Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance, and depletion of these cells in mice results in autoimmunity. In recent years there has been much interest in Th17 cells, which are thought to play an important role in autoimmunity. The regulation of Th17 cells by Treg cells and immunomodulatory therapies is a key area of our research interest. We are interested in understanding how immune responses are dysregulated in autoimmune and inflammatory diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) and the skin disease hidradenitis suppurativa (HS). The overarching aim of the research is to gain a better understanding of the role of the immune system in these diseases in order to identify new therapeutic targets or to predict response to treatment.