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Dr. Alastair Fleming

Assistant Professor (Microbiology)

  Cancer Biology   CHROMATIN   DNA   Gene Expression   Gene Regulation   Genetic Manipulation   Genetics   GENOME ORGANIZATION   Genomes, Genomics   Molecular Biology   Molecular Genetics   Nucleic Acid Structure/Function   Nucleic Acids   Recombinant DNA   TRANSCRIPTION   YEAST
Details Date From Date To
Microbiology Society 2010 2018
Kröger C, Schauer K, Clerkin S, Maertlbauer E and Fleming AB, Draft Genome Sequence and Annotation of Acinetobacter junii MHI21018, Isolated from Bovine Colostrum, Microbiology Resource Announcements, 2019, Journal Article, PUBLISHED  DOI
Church M, Smith KC, Alhussain MM, Pennings S, Fleming AB., Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene, Nucleic Acids Research, 45, (8), 2017, p4413 - 4430, Journal Article, PUBLISHED  URL
Young, Conor P and Hillyer, Cory and Hokamp, Karsten and Fitzpatrick, Darren J and Konstantinov, Nikifor K and Welty, Jacqueline S and Ness, Scott A and Werner-Washburne, Margaret and Fleming, Alastair B and Osley, Mary Ann, Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast, BMC genomics, 18, (1), 2017, p107 , Journal Article, PUBLISHED  DOI
Church MC, Fleming AB, A role for histone acetylation in regulating transcription elongation., Transcription, 2017, Notes: [ 10.1080/21541264.2017.1394423.], Review Article, PUBLISHED  DOI
Conor Young, Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae, Trinity College Dublin, 2015, Thesis, APPROVED
Michael Church, Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Trinity College Dublin, 2015, Thesis, PUBLISHED
Fleming, AB, Beggs S, Church M, Tsukihashi Y, Pennings S., The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene., Biochim Biophys Acta - Gene regulatory Mechanisms, 1839, (11), 2014, p1242 - 1255, Journal Article, PUBLISHED  TARA - Full Text  DOI
Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB, Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP, Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits., PLoS genetics, 10, (10), 2014, pe1004658 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Shieh, G.S., Pan, C.-H., Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., (...), Kao, C.-F., H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast, BMC Genomics, 12, 2011, part. no. 627 , Notes: [PubMed ID: 22188810], Journal Article, PUBLISHED  TARA - Full Text  DOI
Artem Barski, Iouri Chepelev, Joanna Birch, Suresh Cuddapah, Alastair B. Fleming, Dritan Liko, Kairong Cui, Robert J. White and Keji Zhao, Pol II and its associated epigenetic marks co-localize throughout the genome with pol III-transcribed non-coding RNA genes, Nature Molecular & Structural Biology, 17, (5), 2010, p629-634 , Notes: [ PubMed ID: 20418881], Journal Article, PUBLISHED  DOI

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Alastair Fleming, The epigenetic landscape of quiescent yeast cells. , University of Maynooth, 13 Feb, 2015, Invited Talk, PRESENTED
Alastair Fleming, The epigenetic landscape of quiscent yeast cells, Irish Fungal Society Meeting, 11-12 June, 2015, Invited Talk, SUBMITTED
Alastair Fleming, Ursula Bond, Gary Moran and Derek Sullivan, Irish Fungal Society Meeting, 11-12 June , 2015, Trinity College Dublin, Meetings /Conferences Organised, PUBLISHED
Michael Church and Alastair Fleming, Investigating FLO1 gene regulation by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Irish Fungal Society Meeting, NUI Galway, 19-20 June, 2014, Irish Fungal Society, Invited Talk, PRESENTED
Suzanne Beggs and Alastair Fleming, Investigating nucleosome dynamics during transcription elongation in Saccharomyces cerevisiae, EMBO Gene Transcription in Yeast, Sant Feliu de Guíxols, Spain, 14-19 June, 2014, Poster, PRESENTED
Alastair Fleming, Conor Young, Cory Hillyer and Mary Ann Osley, The histone modification landscape of quiescent yeast cells formed during chronological aging, Keystone Conference in Cancer Epigenetics, Santa Fe, New Mexico, USA, 20-24 March, 2013, Poster, PUBLISHED
Alastair Fleming, Chromatin remodelling during yeast stationary phase, University of Cork, 2012, Invited Talk, PUBLISHED
Cory Hillyer, Nikifor Konstantinov, Alastair B. Fleming, and Mary Ann Osley , Histone modification patterns during development of budding yeast stationary phase, Signalling to Chromatin, Cambridge, UK, 7th - 10th Sept 2010, edited by Wellcome Trust , 2010, Poster, PRESENTED
Alastair Fleming, Interplay between H2B ubiquitylation and histone chaperones during transcription, Scottish Chromatin Group, MRC, Edinburgh, UK, 24 th October, 2007, Scottish Chromatin Group, Invited Talk, PRESENTED
Alastair Fleming, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, CMBS seminar series, University of St. Andrews, 10th September, 2007, Invited Talk, PRESENTED


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