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Dr. Alastair Fleming

Associate Professor (Microbiology)
MOYNE INSTITUTE

 Alastair.Fleming@tcd.ie

 3531896 3112


Research Tags

  Cancer Biology   CHROMATIN   DNA   Gene Expression   Gene Regulation   Genetic Manipulation   Genetics   GENOME ORGANIZATION   Genomes, Genomics   Molecular Biology   Molecular Genetics   Nucleic Acid Structure/Function   Nucleic Acids   Recombinant DNA   TRANSCRIPTION   YEAST

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Microbiology Society 2010 2018
Lee B, Church M, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex., PLoS genetics, 19, (8), 2023, pe1010876 , Journal Article, PUBLISHED  DOI
Karahoda B, Pfannenstiel BT, Sarikaya-Bayram Ö, Dong Z, Ho Wong K, Fleming AB, Keller NP, Bayram Ö., The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus., Fungal genetics and biology : FG & B, 169, 2023, p103836 , Journal Article, PUBLISHED  DOI
Brenda Lee, Distinct phenotypes and transcriptomes of tup1 and cyc8 mutants suggest novel roles for TUP1 and CYC8 in Saccharomyces cerevisiae, Trinity College Dublin, 2023, Thesis, PUBLISHED
Karahoda, B. and Pardeshi, L. and Ulas, M. and Dong, Z. and Shirgaonkar, N. and Guo, S. and Wang, F. and Tan, K. and Sarikaya-Bayram, Ã-. and Bauer, I. and Dowling, P. and Fleming, A.B. and Pfannenstiel, B.T. and Luciano-Rosario, D. and Berger, H. and Graessle, S. and Alhussain, M.M. and Strauss, J. and Keller, N.P. and Wong, K.H. and Bayram, Ã-., The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis, Nucleic acids research, 50, (17), 2022, p9797-9813 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Pranay Agarwal, Investigating Tup1-Cyc8 complex function in Saccharomyces cerevisiae following the confirmation and characterization of a TUP1 conditional mutant, Trinity College Dublin, 2022, Thesis, PUBLISHED
Nicole Byrne, Investigating the interplay between the Tup1-Cyc8 and Swi-Snf chromatin remodelling complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2021, Thesis, APPROVED
Frawley D, Greco C, Oakley B, Alhussain MM, Fleming AB, Keller NP, Bayram Ö.Cell , The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus., Cellular Microbiology, 22, (6), 2020, p1-14 , Journal Article, PUBLISHED  DOI
Frawley D, Stroe MC, Oakley BR, Heinekamp T, Straßburger M, Fleming AB, Brakhage AA, Bayram Ö, The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus., Frontiers in Microbiology, 11, (811), 2020, p10.3389/fmicb.2020.00811 , Notes: [10.3389/fmicb.2020.00811], Journal Article, PUBLISHED
Silva LP, Frawley D, Assis LJ, Tierney C, Fleming AB, Bayram O, Goldman GH, Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources., mSphere, 5, (5), 2020, p1-14 , Notes: [10.1128/mSphere.00818-20], Journal Article, PUBLISHED
Mohamed Alhussain, Investigating chromatin remodelling by the Tup1-Cyc8 and Swi-Snf complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2020, Thesis, APPROVED
  

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Alastair Fleming, The epigenetic landscape of quiescent yeast cells. , University of Maynooth, 13 Feb, 2015, Invited Talk, PRESENTED
Alastair Fleming, The epigenetic landscape of quiscent yeast cells, Irish Fungal Society Meeting, 11-12 June, 2015, Invited Talk, SUBMITTED
Alastair Fleming, Ursula Bond, Gary Moran and Derek Sullivan, Irish Fungal Society Meeting, 11-12 June , 2015, Trinity College Dublin, Meetings /Conferences Organised, PUBLISHED
Michael Church and Alastair Fleming, Investigating FLO1 gene regulation by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Irish Fungal Society Meeting, NUI Galway, 19-20 June, 2014, Irish Fungal Society, Invited Talk, PRESENTED
Suzanne Beggs and Alastair Fleming, Investigating nucleosome dynamics during transcription elongation in Saccharomyces cerevisiae, EMBO Gene Transcription in Yeast, Sant Feliu de Guíxols, Spain, 14-19 June, 2014, Poster, PRESENTED
Alastair Fleming, Conor Young, Cory Hillyer and Mary Ann Osley, The histone modification landscape of quiescent yeast cells formed during chronological aging, Keystone Conference in Cancer Epigenetics, Santa Fe, New Mexico, USA, 20-24 March, 2013, Poster, PUBLISHED
Alastair Fleming, Chromatin remodelling during yeast stationary phase, University of Cork, 2012, Invited Talk, PUBLISHED
Cory Hillyer, Nikifor Konstantinov, Alastair B. Fleming, and Mary Ann Osley , Histone modification patterns during development of budding yeast stationary phase, Signalling to Chromatin, Cambridge, UK, 7th - 10th Sept 2010, edited by Wellcome Trust , 2010, Poster, PRESENTED
Alastair Fleming, Interplay between H2B ubiquitylation and histone chaperones during transcription, Scottish Chromatin Group, MRC, Edinburgh, UK, 24 th October, 2007, Scottish Chromatin Group, Invited Talk, PRESENTED
Alastair Fleming, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, CMBS seminar series, University of St. Andrews, 10th September, 2007, Invited Talk, PRESENTED

  

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