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Dr. Darren Fayne

Senior Research Fellow (Biochemistry)

 


O'Boyle, NM, Barrett, I, Greene, LM, Carr, M, Fayne, D, Twamley, B, Knox, AJS, Keely, NO, Zisterer, DM, Meegan, MJ, Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity, Journal of Medicinal Chemistry, 61, (2), 2018, p514 - 534, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Andrew J. Byrne, Sandra A. Bright, Darren Fayne, James P. McKeown, Thomas McCabe, Brendan Twamley, Clive Williams and Mary J. Meegan, Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt's Lymphoma, Medicinal Chemistry, 14 , (1), 2018, p181 - 199, Notes: [DOI: 10.2174/15734064136661710], Journal Article, PUBLISHED
Almahboub, S.A., Narancic, T., Fayne, D., O"Connor, K.E., Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids, Scientific Reports, 8, (1), 2018, Journal Article, PUBLISHED
Malebari, AM, Greene, LM, Nathwani, SM, Fayne, D, O'Boyle, NM, Wang, S, Twamley, B, Zisterer, DM, Meegan, MJ, β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285 , Journal Article, PUBLISHED  DOI  URL
Malebari, A.M., Greene, L.M., Nathwani, S.M., Fayne, D., O'Boyle, N.M., Wang, S., Twamley, B., Zisterer, D.M., Meegan, M.J., ß-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells, European Journal of Medicinal Chemistry, 130, 2017, p261-285 , Journal Article, PUBLISHED
Kelly PM, Keely NO, Bright SA, Yassin B, Ana G, Fayne D, Zisterer DM, Meegan MJ., Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation., Molecules (Basel, Switzerland), 22, (9), 2017, p1440-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Lecca, D., Nevin, D.K., Mulas, G., Casu, M.A., Diana, A., Rossi, D., Sacchetti, G., Fayne, D., Carta, A.R., Erratum: Corrigendum to "Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPAR" agonist in vitro and in MPTP-treated mice" (Neuroscience (2015) 302 (23"35)(S030645221500367X)(10.1016/j.neuroscience.2015.04.026)), Neuroscience, 339, 2016, Journal Article, PUBLISHED
Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ, Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles., Bioorganic & medicinal chemistry, 24, (18), 2016, p4075-99 , Journal Article, PUBLISHED  DOI
Kesel, A.J., Huang, Z., Murray, M.G., Prichard, M.N., Caboni, L., Nevin, D.K., Fayne, D., Lloyd, D.G., Detorio, M.A., Schinazi, R.F., Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire, Antiviral Chemistry and Chemotherapy, 23, (5), 2014, p197-215 , Journal Article, PUBLISHED
Caboni, L., Gálvez-Llompart, M., Gálvez, J., Blanco, F., Rubio-Martinez, J., Fayne, D., Lloyd, D.G., Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2 h -pyrrole-5-one as a non-ligand-binding-pocket antiandrogen, Journal of Chemical Information and Modeling, 54, (10), 2014, p2953-2966 , Journal Article, PUBLISHED
  

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