Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Carsten Ehrhardt

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Dr. Carsten Ehrhardt is an Associate Professor in Pharmaceutics and Pharmaceutical Technology at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. In addition, he is holding the position of Adjunct Associate Professor in the School of Pharmacy, University of Southern California. He was elected Fellow of Trinity College Dublin in 2013. Carsten has obtained his Ph.D. degree in Biopharmaceutics from Saarland University. His research is focused on transport mechanisms and cell physiology of lung epithelial barriers and the development of advanced drug delivery systems for pulmonary administration. He has authored 1 book, 77 peer-reviewed publications, 11 book chapters and more than 220 abstracts and conference proceedings. Carsten has given over 100 invited oral presentations at research institutions, international conferences and workshops. He is affiliated with professional organisations such as Gesellschaft für Wehrmedizin und Wehrpharmazie (VdSO), Deutsche Pharmazeutische Gesellschaft (DPhG), American Association of Pharmaceutical Scientists (AAPS), International Society for Aerosols in Medicine (ISAM), American Physiological Society (APS) and Japanese Society for the Study of Xenobiotics (JSSX). Carsten is the proud recipient of honours and awards from the DPhG, APS Respiratory Chapter and the Galenus Foundation. He actively serves on the Editorial Boards of the American Journal of Physiology - Lung Cellular and Molecular Physiology, Drug Delivery Letters, Journal of Aerosol Medicine and Pulmonary Drug Delivery and Journal of Pharmaceutical Sciences.
  AEROSOL   ALPHA1-ANTITRYPSIN DEFICIENCY   ALVEOLAR EPITHELIAL-CELLS   ALVEOLAR EPITHELIUM   Asthma, Cystic Fibrosis, obstructive airways, interstitial lung diseases, pulmonary fibrosis   Biomedical sciences   Biopharmaceutical aspects of drug delivery systems   BRONCHIAL EPITHELIUM   Cell and tissue development   Drug development and evaluation   IN VITRO MODEL   In vitro testing, trial methods   INHALATION   IN-VITRO CULTURE   LIPOSOMES   LUNG   Membrane transport, structure and dynamics   Physiological and physiochemical barriers to drug absorption   Physiology   Respiratory System
Details Date
Adjunct Assistant Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA February 2008 - present
Professor Invité, Laboratoire de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, France March 2010 - July 2014
Chair, Drug Delivery: Emerging Therapies Networking Group, International Society for Aerosols in Medicine 2011 - 2013
Chair, Imaging, Modeling, and Physiology of Aerosols in the Lung, International Society for Aerosols in Medicine 2013 - 2015
Member, Council, West Coast Salt and Water Club March 2015 - present
Member, Editorial Board, Journal of Aerosol Medicine and Pulmonary Drug Delivery June 2015 - present
Member, Editorial Board, American Journal of Physiology - Lung Cellular and Molecular Physiology August 2015 - present
Member, Awards Committee, International Society for Aerosols in Medicine 2015 - present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Italian Medium Basic Basic
Spanish Basic Basic Basic
Details Date From Date To
Gesellschaft für Wehrmedizin und Wehrpharmazie, VdSO 1997 Present
Deutsche Pharmazeutische Gesellschaft, DPhG 2000 Present
American Association of Pharmaceutical Scientists, AAPS 2002 Present
International Society for Aerosols in Medicine, ISAM 2003 Present
American Physiological Society, APS 2006 Present
Japanese Society for the Study of Xenobiotics, JSSX 2015 present
Y Tega, C Yuzurihara, Y Kubo, SI Akanuma, C Ehrhardt, KI Hosoya, Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells, Drug Metab Pharmacokinet, 31, (1), 2016, p99-101 , Journal Article, PUBLISHED
F Tewes, OL Gobbo, C Ehrhardt, AM Healy, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Appl Mater Interfaces, 8, (2), 2016, p1164-1175 , Journal Article, PUBLISHED
S Nickel, CG Clerkin, MA Selo, C Ehrhardt, Transport mechanisms at the pulmonary mucosa: implications for drug delivery, Expert Opin Drug Deliv, 13, (5), 2016, p667-690 , Review Article, PUBLISHED  DOI
AN Zelikin, C Ehrhardt, AM Healy, Materials and methods for delivery of biological drugs, Nat Chem, 2016, Review Article, ACCEPTED
MS Holmes, JN Seheult, P O'Connell, S D'Arcy, C Ehrhardt, AM Healy, RW Costello, RB Reilly, An acoustic based method to detect and quantify the effect of exhalation into a dry powder inhaler, J Aerosol Med Pulm Drug Deliv, 28, (4), 2015, p247-253 , Journal Article, PUBLISHED
E Schwagerus, S Sladek, ST Buckley, N Armas-Capote, D Alvarez de la Rosa, BJ Harvey, H Fischer, B Illek, H Huwer, N Daum, CM Lehr, C Ehrhardt, Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro, Pflug Arch Eur J Phy, 467, (11), 2015, p2257-2273 , Journal Article, PUBLISHED  DOI
MI Amaro, F Tewes, O Gobbo, L Tajber, OI Corrigan, C Ehrhardt, AM Healy, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, Int J Pharm, 483, (1-2), 2015, p6-18 , Journal Article, PUBLISHED
JJ Salomon, Y Hagos, S Petzke, A Kühne, JC Gausterer, KI Hosoya, C Ehrhardt, Beta-2 adrenergic-agonists are substrates and inhibitors of human organic cation transporter 1, Mol Pharm, 12, (8), 2015, p2633-2641 , Journal Article, PUBLISHED
M Takano, N Sugimoto, C Ehrhardt, R Yumoto, Functional expression of PEPT2 in the human distal lung epithelial cell line NCl-H441, Pharm Res, 32, (12), 2015, p3916-3926 , Journal Article, PUBLISHED  DOI
JJ Salomon, JC Gausterer, T Yahara, KI Hosoya H Huwer, M Hittinger, N Daum-Schneider, CM Lehr, C Ehrhardt, Organic cation transporter function in different in vitro models of human lung epithelium, Eur J Pharm Sci, 80, 2015, p82-88 , Journal Article, PUBLISHED  DOI
  

Page 1 of 10
C Ehrhardt, Transport and efflux systems at the air-blood-barrier, 11th International Conference and Workshop on Biological Barriers, Saarbrücken, Germany, 08/03/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Membrane transporters in lung epithelial barrier, University of Southern California, School of Pharmacy, Los Angeles, CA, 01/04/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, In vitro, ex vivo and in vivo evidence for drug transporter interactions in lung drug disposition , Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 31/05/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Involvement of membrane transporters in pulmonary drug disposition and their role in COPD, Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 01/06.2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Drug transporters in the lungs - How do they contribute to pulmonary drug disposition? , Laboratory of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Osaka, Japan, 03/06/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Biopharmazie der Lunge - Über das Schicksal inhalierter Arzneistoffe, Department für Pharmazeutische Technologie und Biopharmazie, Universität Wien, Wien, Austria, 10/06/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, In vitro, ex vivo and in vivo models of the lungs, DNA-TRAP Workshop on Drug Development to Cross Biological Barriers, University of East Anglia, Norwich, UK, 30/06/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Organic cation transporters in the lungs - their role in drug disposition and as drug targets, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, 19/08/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, MA Selo, CG Clerkin, BN Talbot, JJ Walsh, JB Lewis, PR Reynolds, Y Kato, N Nakamichi, S Nickel, Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo, FASEB J, Experimental Biology Meeting 2016, San Diego, CA, Experimental Biology, 30, (4), 2016, pp982.1 , Meeting Abstract, PUBLISHED
C Ehrhardt, CG Clerkin, MA Selo, J Fallack, S Nickel, Human distal lung epithelial cells express functional MRP1 and BCRP in vitro, AAPS/ITC Joint Workshop on Drug Transporters, Baltimore, MD, 18-20/04/2016, 2016, ppM1003 , Meeting Abstract, PUBLISHED

  

Page 1 of 30
Award Date
International Research Collaboration Award, University of Sydney 2013
Fellowship, Trinity College Dublin 2013
Galenus Support Award 2012, Galenus Privatstiftung 2012
Galenus Support Award 2011, Galenus Privatstiftung 2011
Galenus Support Award 2010, Galenus Privatstiftung 2010
Galenus Support Award 2009, Galenus Privatstiftung 2009
Galenus Support Award 2008, Galenus Privatstiftung 2008
Galenus Support Award 2007, Galenus Privatstiftung 2007
Travel grant from the DFG to attend the Experimental Biology Meeting, Washington, DC, USA 2004
Poster Award at the 8th German Seminar on Aerosol Therapy, Marburg, Germany 2003
Recognition Award for Meritorious Research by a Young Investigator, American Physiological Society 2003
Travel grant from the CRS to attend the 30th Annual Meeting of the CRS, Glasgow, UK 2003
"Förderung der wissenschaftlichen Nachwuchses" Fellowship from the DPhG 2002
Travel grant from the Nagai Foundation to attend the 28th Annual Meeting of the CRS, San Diego, CA, USA 2001
Travel grant from the DPhG to attend the 6th European Congress of Pharmaceutical Sciences - EUFEPS 2000, Budapest, Hungary 2000
I have established an international reputation in my field of expertise, "Inhalation Drug Delivery and Pulmonary Biopharmaceutics". The aim of this field of scientific endeavour is to describe the behaviour of drug and biological molecules following their administration to the lung as inhaled aerosols. The field has become increasingly important over the last 20 years as the incidence of lung-related diseases and the morbidity due to these conditions is increasing a more than 5% per year. My research is primarily preclinical using both cell and animal models, which allows a wide array of discovery and development works. The technical expertise of my laboratory ranges from pharmaceutics to pharmacokinetics, pharmacology, physiology, cell & molecular biology to pathology and immunocytochemistry. Recently, we started multidisciplinary, translational investigations into the role that drug transporters play in the pathogenesis of tobacco-related chronic obstructive pulmonary disease (COPD). Previously, we have been successfully developing the following research projects: - Lung cellular disposition of inhaled beta-2 agonists for asthma therapy - Investigation of drug transporter expression in proximal and distal lung - Characterisation of delta-ENaC expression and function in airway epithelia - Determination of the role of OCTN1 in tobacco smoke-related COPD - Novel lipid-based drug delivery systems for pulmonary delivery of sCT I am an internationally recognised leader in the field of in vitro models of respiratory epithelial barriers and my laboratory has been credited with pioneering work on the development of primary cultures of human alveolar epithelial cells. The unique combination of cell physiological basis and pharmaceutical application has lead to numerous research collaborations, nationally and internationally, as well as to a continuous stream of visitors to my laboratory. I am PI of TBSI and an SFI Strategic Research Cluster - the Irish Drug Delivery Network (commenced December 2007), which brings together expertise from several leading academic institutions (UCD, UCC, RCSI and TCD) and a number of Irish drug delivery companies.