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Dr. Carsten Ehrhardt

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Dr. Carsten Ehrhardt is an Associate Professor in Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences and a Fellow of Trinity College Dublin, Ireland's leading university. He is also holding the position of Adjunct Associate Professor at the School of Pharmacy, University of Southern California (Los Angeles). Carsten has obtained his Ph.D. degree in Biopharmaceutics from Saarland University (Saarbrücken, Germany). His research is focused on transport mechanisms and cell physiology of lung epithelial barriers and the development of advanced drug delivery systems for pulmonary targeting. He has authored 1 book, 59 articles in peer-reviewed journals, 13 invited review articles, 11 book chapters and more than 200 abstracts and conference proceedings. In addition, Carsten has been invited for over 90 presentations at research institutions, international conferences and workshops. He is affiliated with professional organisations such as Gesellschaft für Wehrmedizin und Wehrpharmazie (VdSO), Deutsche Pharmazeutische Gesellschaft (DPhG), American Association of Pharmaceutical Scientists (AAPS), International Society for Aerosols in Medicine (ISAM), and American Physiological Society (APS). Carsten is the proud recipient of honours and awards from the DPhG, APS Respiratory Chapter and the Galenus Foundation.
  AEROSOL   ALPHA1-ANTITRYPSIN DEFICIENCY   ALVEOLAR EPITHELIAL-CELLS   ALVEOLAR EPITHELIUM   Asthma, Cystic Fibrosis, obstructive airways, interstitial lung diseases, pulmonary fibrosis   Biomedical sciences   Biopharmaceutical aspects of drug delivery systems   BRONCHIAL EPITHELIUM   Cell and tissue development   Drug development and evaluation   IN VITRO MODEL   In vitro testing, trial methods   INHALATION   IN-VITRO CULTURE   LIPOSOMES   LUNG   Membrane transport, structure and dynamics   Physiological and physiochemical barriers to drug absorption   Physiology   Respiratory System
Details Date
Adjunct Assistant Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA February 2008 - present
Professor Invité, Laboratoire de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, France March 2010 - July 2014
Chair, Drug Delivery: Emerging Therapies Networking Group, International Society for Aerosols in Medicine 2011 - 2013
Chair, Imaging, Modeling, and Physiology of Aerosols in the Lung, International Society for Aerosols in Medicine 2013 - 2015
Member, Council, West Coast Salt and Water Club March 2015 - present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Italian Medium Basic Basic
Spanish Basic Basic Basic
Details Date From Date To
Gesellschaft für Wehrmedizin und Wehrpharmazie, VdSO 1997 Present
Deutsche Pharmazeutische Gesellschaft, DPhG 2000 Present
American Association of Pharmaceutical Scientists, AAPS 2002 Present
International Society for Aerosols in Medicine, ISAM 2003 Present
American Physiological Society, APS 2006 Present
E Schwagerus, S Sladek, ST Buckley, N Armas-Capote, D Alvarez de la Rosa, BJ Harvey, H Fischer, B Illek, H Huwer, N Daum, CM Lehr, C Ehrhardt, Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro, Pflug Arch Eur J Phy, 2015, Journal Article, IN_PRESS
MI Amaro, F Tewes, O Gobbo, L Tajber, OI Corrigan, C Ehrhardt, AM Healy, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, Int J Pharm, 483, (1-2), 2015, p6-18 , Journal Article, PUBLISHED
JJ Salomon, Y Hagos, S Petzke, A Kühne, JC Gausterer, KI Hosoya, C Ehrhardt, Beta-2 adrenergic-agonists are substrates and inhibitors of human organic cation transporter 1, Mol Pharm, 2015, Journal Article, IN_PRESS
JJ Salomon, C Ehrhardt, KI Hosoya, The verapamil transporter in human alveolar epithelial cells (A549) does not interact with β2-receptor agonists, Drug Metabolism and Pharmacokinetics, 29, (1), 2014, p101-104 , Journal Article, PUBLISHED  TARA - Full Text  DOI
J Swaminathan, OL Gobbo, F Tewes, AM Healy, C Ehrhardt, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, J Aerosol Med Pulm Drug Deliv, 27, (1), 2014, p1-11 , Journal Article, PUBLISHED
F Tewes, C Ehrhardt, AM Healy, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, Eur J Pharm Biopharm, 86, (1), 2014, p98-104 , Journal Article, PUBLISHED
C Ehrhardt, Why do we know so little about absorption pathways in the lung?, Inhalation, 8, (2), 2014, p27-28 , Journal Article, PUBLISHED
JJ Salomon, VE Muchitsch, JC Gausterer, E Schwagerus, H Huwer, N Daum, CM Lehr, C Ehrhardt, The cell line NCI-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier, Mol Pharm, 11, (3), 2014, p995-1006 , Journal Article, PUBLISHED
J Swaminathan, C Ehrhardt, Effect of lyophilisation on liposomal systems for the delivery of salmon calcitonin (sCT), J Liposome Res, 24, (4), 2014, p297-303 , Journal Article, PUBLISHED
JN Seheult, P O'Connell, I Sulaiman, KC Tee, T Bholah, E MacHale, S D'Arcy, MS Holmes, G Crispino-O'Connell, RB Reilly, D Bergin, E Reeves, C Ehrhardt, AM Healy, RW Costello, An acoustic method for monitoring aerosol delivery from a DiskusTM dry powder inhaler, Pharm Res, 31, (10), 2014, p2735-2747 , Journal Article, PUBLISHED
  

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C Ehrhardt, Drug transporters in the lung and it their relevance for pulmonary drug disposition, Universitetet i Tromsø, Institutt for farmasi, Tromsø, Norway, 19/03/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, In vitro, ex vivo and in vivo models for pulmonary drug disposition studies, AstraZeneca, Mölndal, Sweden, 25/03/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, The impact of membrane transporters on drug absorption from the lungs, AstraZeneca, Mölndal, Sweden, 25/03/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, Experimental Biology Meeting 2015, Boston, MA, 31/03/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, The role of drug transporters in inhalation biopharmaceutics, University of Toyama. Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan, 13/04/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, Drug transporters in the lung - expression and interactions with inhaled medicines, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 15/04/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, Arzneistoffabsorption in der Lunge - mehr als nur Diffusion, Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany, 24/03/2015, 2015, Invited Talk, PRESENTED
C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7 , Meeting Abstract, PUBLISHED
C Ehrhardt, A probable association between the ergothioneine transporter, OCTN1 and COPD, 33rd West Coast Salt and Water Club Meeting, Avila Beach, CA, 08/03/2014, 2014, Invited Talk, PRESENTED
C Ehrhardt, In vitro models of human distal lung and their application in pulmonary drug disposition research, Graduate School of Health, University of Technology, Sydney, Sydney, NSW, Australia, 09/04/2014, 2014, Invited Talk, PRESENTED

  

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Award Date
International Research Collaboration Award, University of Sydney 2013
Fellowship, Trinity College Dublin 2013
Galenus Support Award 2012, Galenus Privatstiftung 2012
Galenus Support Award 2011, Galenus Privatstiftung 2011
Galenus Support Award 2010, Galenus Privatstiftung 2010
Galenus Support Award 2009, Galenus Privatstiftung 2009
Galenus Support Award 2008, Galenus Privatstiftung 2008
Galenus Support Award 2007, Galenus Privatstiftung 2007
Travel grant from the DFG to attend the Experimental Biology Meeting, Washington, DC, USA 2004
Poster Award at the 8th German Seminar on Aerosol Therapy, Marburg, Germany 2003
Recognition Award for Meritorious Research by a Young Investigator, American Physiological Society 2003
Travel grant from the CRS to attend the 30th Annual Meeting of the CRS, Glasgow, UK 2003
"Förderung der wissenschaftlichen Nachwuchses" Fellowship from the DPhG 2002
Travel grant from the Nagai Foundation to attend the 28th Annual Meeting of the CRS, San Diego, CA, USA 2001
Travel grant from the DPhG to attend the 6th European Congress of Pharmaceutical Sciences - EUFEPS 2000, Budapest, Hungary 2000
I have established an international reputation in my field of expertise, "Inhalation Drug Delivery and Pulmonary Biopharmaceutics". The aim of this field of scientific endeavour is to describe the behaviour of drug and biological molecules following their administration to the lung as inhaled aerosols. The field has become increasingly important over the last 20 years as the incidence of lung-related diseases and the morbidity due to these conditions is increasing a more than 5% per year. My research is primarily preclinical using both cell and animal models, which allows a wide array of discovery and development works. The technical expertise of my laboratory ranges from pharmaceutics to pharmacokinetics, pharmacology, physiology, cell & molecular biology to pathology and immunocytochemistry. Recently, we started multidisciplinary, translational investigations into the role that drug transporters play in the pathogenesis of tobacco-related chronic obstructive pulmonary disease (COPD). Previously, we have been successfully developing the following research projects: - Lung cellular disposition of inhaled beta-2 agonists for asthma therapy - Investigation of drug transporter expression in proximal and distal lung - Characterisation of delta-ENaC expression and function in airway epithelia - Determination of the role of OCTN1 in tobacco smoke-related COPD - Novel lipid-based drug delivery systems for pulmonary delivery of sCT I am an internationally recognised leader in the field of in vitro models of respiratory epithelial barriers and my laboratory has been credited with pioneering work on the development of primary cultures of human alveolar epithelial cells. The unique combination of cell physiological basis and pharmaceutical application has lead to numerous research collaborations, nationally and internationally, as well as to a continuous stream of visitors to my laboratory. I am PI of TBSI and an SFI Strategic Research Cluster - the Irish Drug Delivery Network (commenced December 2007), which brings together expertise from several leading academic institutions (UCD, UCC, RCSI and TCD) and a number of Irish drug delivery companies.