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Dr. Carsten Ehrhardt

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Dr. Carsten Ehrhardt is Associate Professor in Pharmaceutics and Pharmaceutical Technology at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. In addition, he is holding the position of Adjunct Associate Professor in the School of Pharmacy, University of Southern California. He was elected Fellow of Trinity College Dublin in 2013. Carsten has obtained his Ph.D. degree in Biopharmaceutics from Saarland University in 2003. His research is focused on lung drug disposition, pulmonary epithelial transport and molecular origins of airways disease. He has edited 1 book and (co-)authored 81 peer-reviewed publications, 11 book chapters and more than 230 abstracts and conference proceedings. Carsten has given over 120 invited oral presentations at research institutions, international conferences and workshops. He is a member of Gesellschaft für Wehrmedizin und Wehrpharmazie (VdSO), Deutsche Pharmazeutische Gesellschaft (DPhG), American Association of Pharmaceutical Scientists (AAPS), International Society for Aerosols in Medicine (ISAM), American Physiological Society (APS) and Japanese Society for the Study of Xenobiotics (JSSX). Carsten is the proud recipient of honours and awards from DPhG, APS and Galenus Foundation. He actively serves on the Editorial Boards of the American Journal of Physiology - Lung Cellular and Molecular Physiology, Drug Delivery Letters, Journal of Aerosol Medicine and Pulmonary Drug Delivery, Journal of Pharmaceutical Sciences and European Journal of Pharmaceutics and Biopharmaceutics.
  AEROSOL   ALVEOLAR EPITHELIAL-CELLS   ALVEOLAR EPITHELIUM   Asthma, Cystic Fibrosis, obstructive airways, interstitial lung diseases, pulmonary fibrosis   Biomedical sciences   Biopharmaceutical aspects of drug delivery systems   BRONCHIAL EPITHELIUM   Cell and tissue development   Drug development and evaluation   IN VITRO MODEL   In vitro testing, trial methods   INHALATION   IN-VITRO CULTURE   LIPOSOMES   LUNG   Membrane transport, structure and dynamics   Physiological and physiochemical barriers to drug absorption   Physiology   Respiratory System
Details Date
Member, Board of Examiners in Pharmaceutical Technology 2002 - 2011
Local Co-ordinator, Marie-Curie Early Stage Training (EST) Network "Galenos EuroPhD in Advanced Drug Delivery" 2006 - 2010
Adjunct Assistant Professor, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 2008 - present
Professor Invité, Laboratoire de Pharmacie Galénique Industrielle, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon, France 2010 - July 2014
Chair, Drug Delivery: Emerging Therapies Networking Group, International Society for Aerosols in Medicine 2011 - 2013
Member, Management Committee, COST Action BM1201: Developmental Origins of Chronic Lung Disease 2012 - 2016
Chair, Imaging, Modeling, and Physiology of Aerosols in the Lung, International Society for Aerosols in Medicine 2013 - 2015
Member, Management Committee, COST Action MP1404: Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines (SimInhale) 2014 - 2018
Vice-Leader, WG5: Toxicity, Risk Assessment and Regulation, COST Action MP1404: Simulation and pharmaceutical technologies for advanced patient-tailored inhaled medicines (SimInhale) 2014 - 2018
Member, Council, Western Epithelial Biology Society (formerly West Coast Salt and Water Club) 2015 - present
Member, Editorial Board, Journal of Aerosol Medicine and Pulmonary Drug Delivery 2015 - present
Member, Editorial Board, American Journal of Physiology - Lung Cellular and Molecular Physiology 2015 - present
Member, Awards Committee, International Society for Aerosols in Medicine 2015 - present
Member, Editorial Board, European Journal of Pharmaceutics and Biopharmaceutics 2017 - present
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Fluent Fluent Fluent
Italian Medium Basic Basic
Spanish Basic Basic Basic
Details Date From Date To
Gesellschaft für Wehrmedizin und Wehrpharmazie, VdSO 1997 Present
Deutsche Pharmazeutische Gesellschaft, DPhG 2000 Present
American Association of Pharmaceutical Scientists, AAPS 2002 Present
International Society for Aerosols in Medicine, ISAM 2003 Present
American Physiological Society, APS 2006 Present
Japanese Society for the Study of Xenobiotics, JSSX 2015 Present
European Journal of Pharmaceutics and Biopharmaceutics, Amsterdam, The Netherlands, Elsevier Science, [eds.], 2017, Editorial Board, PUBLISHED
X Hu, FF Yang, CY Liu, C Ehrhardt, YH Liao, In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells, Eur J Pharm Biopharm, 114, 2017, p29-37 , Journal Article, PUBLISHED  DOI
S Nickel, MA Selo, J Fallack, H Huwer, N Schneider-Daum, CM Lehr, C Ehrhardt, Expression and activity of breast cancer resistance protein (BCRP) in human distal lung epithelial cells in vitro, Pharm Res, 2017, Journal Article, IN_PRESS  DOI
C Ehrhardt, P Bäckman, W Couet, C Edwards, B Forbes, M Fridén, M Gumbleton, KI Hosoya, Y Kato, T Nakanishi, M Takano, T Terasaki, R Yumoto(ed.), Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs, J Pharm Sci, Dublin, Ireland, 22-23/09/2016, 2017, Proceedings of a Conference, IN_PRESS  DOI
Y Tega, C Yuzurihara, Y Kubo, SI Akanuma, C Ehrhardt, KI Hosoya, Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells, Drug Metab Pharmacokinet, 31, (1), 2016, p99-101 , Journal Article, PUBLISHED  DOI
Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175 , Journal Article, PUBLISHED  TARA - Full Text  DOI
S Nickel, CG Clerkin, MA Selo, C Ehrhardt, Transport mechanisms at the pulmonary mucosa: implications for drug delivery, Expert Opin Drug Deliv, 13, (5), 2016, p667-690 , Review Article, PUBLISHED  DOI
Zelikin AN, Ehrhardt C, Healy AM, Materials and methods for delivery of biological drugs, Nature Chemistry, 8, (11), 2016, p997-1007 , Review Article, PUBLISHED  DOI
American Journal of Physiology - Lung Cellular and Molecular Physiology , Bethesda, MD, American Physiological Society, 2015, Editorial Board, PUBLISHED
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Rochelle, NY, Mary Ann Liebert, Inc., 2015, Editorial Board, PUBLISHED
  

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C Ehrhardt, Innovative Formulierungen für die Inhalationstherapie mit Biopharmazeutika, Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Germany, 10/01/2017, 2017, Invited Talk, PRESENTED
C Ehrhardt, Ergothioneine, OCTN1 and COPD, 36th Western Epithelial Biology Society Meeting, Avila Beach, CA, 04/03/2017, 2017, Invited Talk, PRESENTED
C Ehrhardt, Organic cation transporters in the lung, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, 05/05/2017, 2017, Invited Talk, PRESENTED
C Ehrhardt, Transport and efflux systems at the air-blood-barrier, 11th International Conference and Workshop on Biological Barriers, Saarbrücken, Germany, 08/03/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Membrane transporters in lung epithelial barrier, University of Southern California, School of Pharmacy, Los Angeles, CA, 01/04/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, In vitro, ex vivo and in vivo evidence for drug transporter interactions in lung drug disposition , Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, 31/05/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Involvement of membrane transporters in pulmonary drug disposition and their role in COPD, Department of Molecular Cell Physiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 01/06.2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Drug transporters in the lungs - How do they contribute to pulmonary drug disposition? , Laboratory of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Osaka, Japan, 03/06/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, Biopharmazie der Lunge - Über das Schicksal inhalierter Arzneistoffe, Department für Pharmazeutische Technologie und Biopharmazie, Universität Wien, Wien, Austria, 10/06/2016, 2016, Invited Talk, PRESENTED
C Ehrhardt, In vitro, ex vivo and in vivo models of the lungs, DNA-TRAP Workshop on Drug Development to Cross Biological Barriers, University of East Anglia, Norwich, UK, 30/06/2016, 2016, Invited Talk, PRESENTED

  

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Award Date
International Research Collaboration Award, University of Sydney 2013
Fellowship, Trinity College Dublin 2013
Galenus Support Award 2012, Galenus Privatstiftung 2012
Galenus Support Award 2011, Galenus Privatstiftung 2011
Galenus Support Award 2010, Galenus Privatstiftung 2010
Galenus Support Award 2009, Galenus Privatstiftung 2009
Galenus Support Award 2008, Galenus Privatstiftung 2008
Galenus Support Award 2007, Galenus Privatstiftung 2007
Travel grant from the DFG to attend the Experimental Biology Meeting, Washington, DC, USA 2004
Poster Award at the 8th German Seminar on Aerosol Therapy, Marburg, Germany 2003
Recognition Award for Meritorious Research by a Young Investigator, American Physiological Society 2003
Travel grant from the CRS to attend the 30th Annual Meeting of the CRS, Glasgow, UK 2003
"Förderung der wissenschaftlichen Nachwuchses" Fellowship from the DPhG 2002
Travel grant from the Nagai Foundation to attend the 28th Annual Meeting of the CRS, San Diego, CA, USA 2001
Travel grant from the DPhG to attend the 6th European Congress of Pharmaceutical Sciences - EUFEPS 2000, Budapest, Hungary 2000
I have established an international reputation in the field of Pulmonary Biopharmaceutics. The scientific aim of my work is to describe the behaviour of drugs following their administration to the lung as inhaled aerosols, i.e. lung drug disposition and pulmonary epithelial transport. Moreover, I have developed a keen interest in the molecular origins of lung disease. Over the last 20 years, the incidence of lung-related diseases and the morbidity due to these conditions is increasing at more than 5% per year. With 1 in 7 people in Ireland having an undiagnosed lung condition and Ireland having the third highest death rate from lung disease in Europe, causing 1 in 5 deaths, the potential impact of my work becomes clear. In my lab we primarily employ pre-clinical models. We have established organotypic in vitro, ex vivo and experimental in vivo models, which allow a wide array of discovery and development studies. Inter alia, we have been credited with pioneering the development of primary cultures of human alveolar epithelial cells. The expertise of my laboratory includes techniques from the areas of pharmaceutics, pharmacokinetics, pharmacology, electrophysiology, cell and molecular biology and immunocytochemistry. The unique combination of cell physiological basis and pharmaceutical application has led to numerous research collaborations, nationally and internationally, as well as to a continuous stream of visiting researchers to my laboratory. At the moment, we are involved in a number of international, multidisciplinary, translational studies into the role that drug transporters play in the pathogenesis of lung diseases. In this context, we are studying, e.g. the role of ergothioneine and its physiological transporter OCTN1 in the development and progression of tobacco-related chronic obstructive pulmonary disease (COPD). This study brings together researcher from TCD, St. James's Hospital, Brigham Young University, University of Kanazawa and University Medical Center Groningen and is financially supported by a Clinical Investigator Award from the Flight Attendant Medical Research Institute (FAMRI). My lab continuously publishes in in high ranking peer-reviewed journals in the subject areas of Pharmaceutics, Pharmacology and Physiology. One of the highlights of our endeavours so far was the invitation to publish a review article in Nature Chemistry (Zelikin et al. 2016). Another of our publications (Paszko et al. 2011) achieved highly cited paper status according to Essential Science Indicators, i.e. it has received enough citations to place it in the top 1% of its academic field based on a highly cited threshold for the field and publication year. Chapters from Drug Absorption Studies, a book edited by me and published by Springer in 2008, were downloaded >65,000 times, placing it in the top 25% most downloaded eBooks in the relevant eBook Collection in 2016. My total research grant income as PI amounts to more than 2.5 million euros, of which >440,000 euros were secured in the last three years. In addition, I am involved as co-PI in a number of international collaborations, e.g. a TÜBITAK grant with Dr Ayca Yıldız Peköz from Istanbul University and a Lung Foundation Netherlands grant with Dr Irene Heijink from the University of Groningen. To maintain the momentum, I have recently submitted an SFI CDA proposal in collaboration with Dr Andrej Budanov (School of Biochemistry and Immunology) and another TÜBITAK grant with Dr. Peköz. I am also in advanced stages of discussions about an EI Innovation Partnership Programme submission with Mylan Ltd.