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Professor David Williams

Professor of Chemical Biology (Biochemistry)
BIOMEDICAL SCIENCES INSTITUTE

Dean Engineering,Mathematics & Science (Faculty Office : FEMS)

  5-HYDROXYTRYPTAMINE UPTAKE   ANTIDEPRESSANT DRUGS   ANTIPROLIFERATIVE ACTION   APOPTOSIS   BCR-ABL   BENZODIAZEPINE BINDING-SITES   BENZODIAZEPINES   CANCER   CASPASES   CELL CYCLE   CELL PROLIFERATION   CHOLESTEROL   Computational Biology   DIFFERENTIATION   ESTROGEN-RECEPTOR   GABA TRANSPORTER   Immunology, Immunotherapy   In Vitro Testing, Trial Methods   INSECTICIDES   L-GLUTAMATE TRANSPORTER   LIGAND   MITOCHONDRIA   Molecular Biology   PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE   PYRROLO-1,5-BENZOXAZEPINES   PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS   RECEPTOR LIGANDS   RECEPTORS   SEROTONIN TRANSPORTER   Structural Biology, Determination, Function
Details Date
Member and sometime Chair of The National Committee for Biochemistry 1993-96,00-03
Secretary and Member of The Neurochemical Group Committee of The Biochemical Society 1990-95
Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees 1991-2
Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students 1987-92
External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc
Chairman Organising committee for EU TMR Euroconference on Neuronal Transporters Dublin 1998 1998
Member Organising Committees for 636 and 648th Biochemical Society Meeting - Dublin 1990, 2002, 21st FEBS Meeting -Dublin 1992, INSERM Phillipe Laudet Conference on Neuronal transporters - Strasbourg, 1993
NUI Phelan Scholarship Evaluation Panel 2003-
Chair of Local Organising Committee, and Member of International Programme Committee for the 9th General Meeting of the European Society for Neurochemistry, Dublin 1992 1992
Details Date From Date To
Member of the Society for Neuroscience 2000
Member and Council Member of European Society for Neurochemistry 1990
Member of The International Society for Neurochemistry 1990
Royal Irish Academy 1995
The Biochemical Society 1970
Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells., Biochemical pharmacology, 87, (4), 2014, p611-24 , Journal Article, PUBLISHED
McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53 , Journal Article, PUBLISHED
Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T, Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases., Organic & biomolecular chemistry, 12, (34), 2014, p6610-23 , Journal Article, PUBLISHED
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46 , Journal Article, PUBLISHED  DOI
Bright SA, Brinkø A, Larsen MT, Sinning S, Williams DC, and Jensen HH. , . Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma, Bioorg Med Chem Lett. , 23, 2013, p1220 - 1224, Journal Article, PUBLISHED  DOI
Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM, Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells., International journal of oncology, 2013, Journal Article, PUBLISHED
Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M, PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines., European journal of pharmacology, 2013, Journal Article, PUBLISHED
Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T, Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent., Chemical communications (Cambridge, England), 49, (76), 2013, p8522-8524 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926, Journal Article, PUBLISHED
Caboni L, Kinsella GK, Blanco F, Fayne D, Jagoe WN, Carr M, Williams DC, Meegan MJ, Lloyd DG, 'True' antiandrogens - selective non ligand-binding pocket disruptors of androgen receptor-coactivator interactions: Novel Tools for Prostate Cancer., Journal of Medicinal Chemistry, 55, (4), 2012, p1635 - 1644, Journal Article, PUBLISHED  DOI
  

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Haase, J., Killian, A-M., Magnani, F., and Williams, D.C., Regulation of the serotonin transporter by interacting proteins, Biochem. Soc. Trans., 29, 2001, p722 - 728, Journal Article, PUBLISHED
Zisterer, D.M., McGee, M.M., Campiani.G.C., Ramunno, A., Fattorusso, C., Nacci, V., Lawler,M., and Williams, D.C., Pyrrolo-1,5, benzoxazepines: a new class of apoptotic agents, Biochem. Soc. Trans., 29, 2001, 704 - 706, Journal Article, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 23rd Annual Pharmacy Joint Research Seminar, Trinity College Dublin, 2000, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., Zisterer, D.M., Campiani, G.C., Fattorusso, C., and Catalanotti, B., Novel conformationally restrained estrogen receptor modulators - design, synthesis, and antagonistic effects in human breast cancer cells, Proceedings of the Molecular Graphics and Modelling Society Symposium on Structure-Based Drug Design, St. Catherine's College, University of Oxford, 2000, Notes: [Abstract will also be published in Journal of Molecular Modelling, 2001], Conference Paper, PUBLISHED
Hughes, R.B., Meegan, M.J., Lloyd, D.G., Williams, D.C. and Zisterer, D.M., Investigation of diaryl benzoxepines as novel antiestrogens and selective estrogen receptor modulators (SERMs), Proceedings of the 22nd Annual Pharmacy Joint Research Seminar, Queens University Belfast, 1999, 1999, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 10th International RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, 1999, Conference Paper, PUBLISHED
Griffiths, R., Grieve, A., Scollon, J., Scott, M., Williams., D.C. and Meredith, C., Preliminary validation of an in vitro test for assessment of excitotoxicity by measurement of early c-fos mRNA levels, J. Neurochem., 73, 1999, pS146A , Journal Article, PUBLISHED
Haase, J., Schloss, P., and Williams, D.C., Regulation of the serotonin transporter: Identification of interacting proteins using a yeast two-hybrid system, J.Neurochem., 73, 1999, pS98D , Journal Article, PUBLISHED
Elliott, G., Campiani, G., Drejer, J., Griffiths, R., Hildebrand, H., Meredith, C., Schousboe, A., Schmuck, G. and Williams, D.C., Demonstration of an in vitro test for excitotoxicity based on early response gene measurement, Alternatives to Laboratory Animals (ATLA), 27, 1999, p289 , Journal Article, PUBLISHED
Zisterer, D.M. & Williams, D.C., Hexachlorocyclohexanes inhibits steroidogenesis in Y1 cells: Absence of correlation with binding to the peripheral-type benzodiazepine receptor, J. Neurochem., 66, (suppl. 2), 1996, pS87C , Journal Article, PUBLISHED

  

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Award Date
Elected Fellow of Trinity College 1987
Elected To Membership of Royal Irish Academy 1995
Current Research Interests and Projects