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Professor Clive Williams

Fellow Emeritus (Fellows Emeritii)


Details Date
Member and sometime Chair of The National Committee for Biochemistry 1993-96,00-03
Secretary and Member of The Neurochemical Group Committee of The Biochemical Society 1990-95
Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees 1991-2
Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students 1987-92
External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc
Chairman Organising committee for EU TMR Euroconference on Neuronal Transporters Dublin 1998 1998
Member Organising Committees for 636 and 648th Biochemical Society Meeting - Dublin 1990, 2002, 21st FEBS Meeting -Dublin 1992, INSERM Phillipe Laudet Conference on Neuronal transporters - Strasbourg, 1993
NUI Phelan Scholarship Evaluation Panel 2003-
Chair of Local Organising Committee, and Member of International Programme Committee for the 9th General Meeting of the European Society for Neurochemistry, Dublin 1992 1992
Details Date From Date To
Member of the Society for Neuroscience 2000
Member and Council Member of European Society for Neurochemistry 1990
Member of The International Society for Neurochemistry 1990
Royal Irish Academy 1995
The Biochemical Society 1970
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54 , Journal Article, PUBLISHED  DOI
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M, Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells., Cancer biology & therapy, 2015, p0 , Journal Article, PUBLISHED
Ryan GJ, Poynton FE, Elmes RB, Erby M, Williams DC, Quinn SJ, Gunnlaugsson T, Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates., Dalton transactions (Cambridge, England : 2003), 44, (37), 2015, p16332-44 , Journal Article, PUBLISHED
Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505 , Journal Article, PUBLISHED
Thorfinnur Gunnlaugsson, Miguel Martínez-Calvo, Kim Orange, Robert B. P. Elmes, Bjørn la Cour Poulsen and D. Clive Williams , Ru(II)-polypyridyl surface functionalised gold nano-particles as DNA targeting supramolecular structures and luminescent cellular imaging agents, Nanoscale, 2015, Journal Article, IN_PRESS  URL
Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells., Biochemical pharmacology, 87, (4), 2014, p611-24 , Journal Article, PUBLISHED
McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53 , Journal Article, PUBLISHED
Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T, Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases., Organic & biomolecular chemistry, 12, (34), 2014, p6610-23 , Journal Article, PUBLISHED
Banerjee S, Bright SA, Smith JA, Burgeat J, Martinez-Calvo M, Williams DC, Kelly JM, Gunnlaugsson T, Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases., The Journal of organic chemistry, 79, (19), 2014, p9272-83 , Journal Article, PUBLISHED
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46 , Journal Article, PUBLISHED  DOI

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Haase, J., Killian, A-M., Magnani, F., and Williams, D.C., Regulation of the serotonin transporter by interacting proteins, Biochem. Soc. Trans., 29, 2001, p722 - 728, Journal Article, PUBLISHED
Zisterer, D.M., McGee, M.M., Campiani.G.C., Ramunno, A., Fattorusso, C., Nacci, V., Lawler,M., and Williams, D.C., Pyrrolo-1,5, benzoxazepines: a new class of apoptotic agents, Biochem. Soc. Trans., 29, 2001, 704 - 706, Journal Article, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 23rd Annual Pharmacy Joint Research Seminar, Trinity College Dublin, 2000, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., Zisterer, D.M., Campiani, G.C., Fattorusso, C., and Catalanotti, B., Novel conformationally restrained estrogen receptor modulators - design, synthesis, and antagonistic effects in human breast cancer cells, Proceedings of the Molecular Graphics and Modelling Society Symposium on Structure-Based Drug Design, St. Catherine's College, University of Oxford, 2000, Notes: [Abstract will also be published in Journal of Molecular Modelling, 2001], Conference Paper, PUBLISHED
Hughes, R.B., Meegan, M.J., Lloyd, D.G., Williams, D.C. and Zisterer, D.M., Investigation of diaryl benzoxepines as novel antiestrogens and selective estrogen receptor modulators (SERMs), Proceedings of the 22nd Annual Pharmacy Joint Research Seminar, Queens University Belfast, 1999, 1999, Conference Paper, PUBLISHED
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 10th International RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, 1999, Conference Paper, PUBLISHED
Griffiths, R., Grieve, A., Scollon, J., Scott, M., Williams., D.C. and Meredith, C., Preliminary validation of an in vitro test for assessment of excitotoxicity by measurement of early c-fos mRNA levels, J. Neurochem., 73, 1999, pS146A , Journal Article, PUBLISHED
Haase, J., Schloss, P., and Williams, D.C., Regulation of the serotonin transporter: Identification of interacting proteins using a yeast two-hybrid system, J.Neurochem., 73, 1999, pS98D , Journal Article, PUBLISHED
Elliott, G., Campiani, G., Drejer, J., Griffiths, R., Hildebrand, H., Meredith, C., Schousboe, A., Schmuck, G. and Williams, D.C., Demonstration of an in vitro test for excitotoxicity based on early response gene measurement, Alternatives to Laboratory Animals (ATLA), 27, 1999, p289 , Journal Article, PUBLISHED
Zisterer, D.M. & Williams, D.C., Hexachlorocyclohexanes inhibits steroidogenesis in Y1 cells: Absence of correlation with binding to the peripheral-type benzodiazepine receptor, J. Neurochem., 66, (suppl. 2), 1996, pS87C , Journal Article, PUBLISHED


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Award Date
Elected Fellow of Trinity College 1987
Elected To Membership of Royal Irish Academy 1995
Current Research Interests and Projects