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Dr. Margaret Dunne

Senior Research Fellow (Surgery)

 


  COELIAC DISEASE   COLORECTAL CANCER   HUMAN DENDRITIC CELLS   HUMAN T-CELLS   Mucosal-associated invariant T cells   OESOPHAGEAL ADENOCARCINOMA   TCR GAMMA DELTA(+) T CELLS
 Development of prognostic screening tools to predict patient response to neoadjuvant chemoradiotherapy treatment for oesophageal adenocarcinoma
 Investigating the role of innate lymphocyte subsets in oesophageal adenocarcinoma - is inflammation a negative regulator of response to therapy?
 Investigating the role of regulatory T cells in colorectal cancer
 Elucidating the role of innate lymphocytes in coeliac disease pathogenesis

Details Date
Presented a poster at the 2017 Cell Symposium in San Diego, USA. 12-06-2017
Presented a poster at the CRUK's Oesophageal Symposium, Cambridge, UK. 27/04/2017
Poster presentation at the 9th International Cancer Conference, Trinity Biomedical Sciences Institute, Dublin Sept 2014
Oral presentation at the 8th National Barrett's Symposium, University College London April 2014
Presented 2 posters at the Irish Association for Cancer Research annual meeting, Galway Feb 2014
Oral presentations at the Irish Society for Immunology annual meeting 2013, 2009, 2008 & 2007
Poster presentation at the 5th International γδ T cell conference, Freiburg, Germany 2012
Oral presentation at the 25th Working Group on Prolamin Analysis & Toxicity (WGPAT), Fellbach, Germany 2011
Poster presentation at the 14th International Coeliac Disease Symposium, Oslo, Norway 2011
Poster presentation at Trinity College Dublin Tercentenary Symposium, Dublin 2011
Poster presentation at 4th International γδ T cell conference, Kiel, Germany 2010
Poster presentation at Institute of Molecular Medicine annual conference, Dublin 2008
Poster presentations at Irish Society for Immunology annual meetings 2010 & 2011
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Member of the Irish Society for Immunology 2005 Present
Member of the Irish and European Associations for Cancer Research (IACR, EACR) 2013 Present
Member of the γδ T cell forum 2010 Present
Dunne M., Michielsen A., O"Sullivan K., Cathcart M., Feighery R., Doyle B., Doyle B., Watson J., O"Farrell N., Ravi N., Kay E., Reynolds J., Ryan E., O"Sullivan J., HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients, Cancer Immunology, Immunotherapy, 66, (7), 2017, p841-850 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dunne M., Dunne M., Ryan C., Nolan B., Nolan B., Tosetto M., Tosetto M., Geraghty R., Winter D., Winter D., O'Connell P., O'Connell P., Hyland J., Hyland J., Doherty G., Doherty G., Sheahan K., Sheahan K., Sheahan K., Ryan E., Ryan E., Fletcher J., Fletcher J., Enrichment of inflammatory IL-17 and TNF-" secreting CD4+ T cells within colorectal tumors despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1, Frontiers in Oncology, 6, (MAR), 2016, Journal Article, PUBLISHED  TARA - Full Text  DOI
Guinan, E.M., Doyle, S.L., O"Neill, L., Dunne, M.R., Foley, E.K., O"Sullivan, J., Reynolds, J.V., Hussey, J., Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study, Supportive Care in Cancer, 25, (3), 2016, p749 - 756, Journal Article, PUBLISHED  DOI
Conroy MJ, Dunne MR, Donohoe CL, Reynolds JV, Obesity-associated cancer: an immunological perspective., The Proceedings of the Nutrition Society, 75, (2), 2015, p125 - 138, Journal Article, PUBLISHED  DOI
Comerford R, Coates C, Byrne G, Lynch S, Dunne P, Dunne M, Kelly J, Feighery C, Characterisation of tissue transglutaminase-reactive T cells from patients with coeliac disease and healthy controls , Clinical Immunology, 154, (2), 2014, p155 - 163, Journal Article, PUBLISHED  DOI  URL
Dunne, MR, Elliott, L, Hussey, S, Mahmud, N, Kelly, J, Doherty, DG, Feighery, CF, Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease, PLOS ONE, 8, (10), 2013, p76008 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells, Journal of Immunology, 191, (1), 2013, p30 - 34, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Shea D, Corrigan M, Dunne MR, Woods C, Gaoatswe G, O'Connell J, Hogan AE, Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection, International Journal of Obesity, 37, (11), 2013, Journal Article, PUBLISHED  DOI
Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207 , Journal Article, PUBLISHED  TARA - Full Text
Dunne MR, Madrigal-Estebas L, Tobin LM, Doherty DG, (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vã9Vä2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells, Cancer Immunology Immunotherapy , 59, 2010, p1109 - 1120, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
  

Page 1 of 2
Flow Cytometric Analysis of Human Small Intestinal Lymphoid Cells in, editor(s)Anthony W Ryan , Celiac Disease Methods and Protocols, Humana Press, 2015, [Dunne MR], Book Chapter, PUBLISHED
Celiac Disease: Background and Historical Context in, editor(s)Anthony W Ryan , Celiac Disease , Springer, 2015, pp3 - 14, [Graham D. Turner, Margaret R. Dunne, Anthony W. Ryan], Book Chapter, PUBLISHED

  

Award Date
Health Research Award 02/05/2016
Irish Research Council Government of Ireland Postdoctoral Fellow 2014
Dorothy Price medal (NUI Maynooth) 2008
John & Pat Hume Postgraduate Scholarship 2005
Irish Research Council for Science, Engineering & Technology Postgraduate Scholarship 2005
My research involves improving the understanding of roles played by innate immune cells in human health and disease, and translation of this information for therapeutic applications. My research projects to date have focussed on elucidating the function of innate lymphocytes, in particular γδ T cells and dendritic cells, in health and disease, and their contribution to host immunity.