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Dr. Margaret Dunne

Research Assistant Professor (Surgery)


  Age related diseases   Angiogenesis   Biomedical sciences   Cancer genetics and cell biology including metastasis   cancer immunology   Cell and tissue maintenance, repair and ageing   Cellular, molecular and developmental immunology   Chronic inflamation   Coeliac disease   COLORECTAL CANCER   Diagnostics   gastrointestinal cancer   Health outcomes   HUMAN DENDRITIC CELLS   HUMAN T-CELLS   immune prognostic markers   Immune system   Immunoassays   In vitro testing, trial methods   Innate immunology   Leukocyte Biology   Medical Sciences, Research   Mucosal immunology   Mucosal-associated invariant T cells   OESOPHAGEAL ADENOCARCINOMA   Oesophageal cancer   Oesophageal, gastric, intestinal and pancreatic diseases   Pathology   Predictive Biomarkers   Public health   TCR GAMMA DELTA(+) T CELLS   Tumour immunology and immunotherapy   unconventional T cells
 Promoting Education and Research Knowledge (PERK)
 Assessment of the predictive value of immune and histological parameters in oesophageal adenocarcinoma using digital pathology
 Development of prognostic screening tools to predict patient response to neoadjuvant chemoradiotherapy treatment for oesophageal adenocarcinoma
 Investigating the role of innate lymphocyte subsets in oesophageal adenocarcinoma - is inflammation a negative regulator of response to therapy?
 Investigating the role of regulatory T cells in colorectal cancer

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Details Date
Presented a poster at the European Congress for Immunology, Amsterdam 2-5th Sept
Presented a poster at the 2017 Cell Symposium in San Diego, USA. 12-06-2017
Presented a poster at the CRUK's Oesophageal Symposium, Cambridge, UK. 27/04/2017
Poster presentation at the 9th International Cancer Conference, Trinity Biomedical Sciences Institute, Dublin Sept 2014
Oral presentation at the 8th National Barrett's Symposium, University College London April 2014
Presented 2 posters at the Irish Association for Cancer Research annual meeting, Galway Feb 2014
Oral presentations at the Irish Society for Immunology annual meeting 2013, 2009, 2008 & 2007
Poster presentation at the 5th International γδ T cell conference, Freiburg, Germany 2012
Oral presentation at the 25th Working Group on Prolamin Analysis & Toxicity (WGPAT), Fellbach, Germany 2011
Poster presentation at the 14th International Coeliac Disease Symposium, Oslo, Norway 2011
Poster presentation at Trinity College Dublin Tercentenary Symposium, Dublin 2011
Poster presentation at 4th International γδ T cell conference, Kiel, Germany 2010
Poster presentation at Institute of Molecular Medicine annual conference, Dublin 2008
Poster presentations at Irish Society for Immunology annual meetings 2010 & 2011
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Member of the Irish Society for Immunology 2005 Present
Member of the Irish and European Associations for Cancer Research (IACR, EACR) 2013 Present
Member of the γδ T cell forum 2010 Present
Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A. W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha, Dunne, Margaret R., Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma, Frontiers in Immunology, 10, 2019, Journal Article, PUBLISHED  TARA - Full Text  DOI
Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129 , Journal Article, PUBLISHED  DOI
Amy Buckley, Becky Bibby, Margaret Dunne, Susan Kennedy, Maria Davern, Breandan Kennedy, Stephen Maher, Jacintha O'Sullivan, Characterisation of an isogenic model of cisplatin resistance in oesophageal adenocarcinoma cells, Pharmaceuticals, 2019, Journal Article, IN_PRESS
*Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238 , Notes: [*JOINT FIRST AUTHORSHIP], Journal Article, PUBLISHED  DOI  URL
Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J., Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma., Oncotarget, 9, (72), 2018, p33634-33647 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dunne PJ, Maher CO, Freeley M, Dunne K, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, CD3" Expression Defines Functionally Distinct Subsets of V"1 T Cells in Patients With Human Immunodeficiency Virus Infection., Frontiers in Immunology, 2018, Journal Article, PUBLISHED
Dunne M., Michielsen A., O"Sullivan K., Cathcart M., Feighery R., Doyle B., Doyle B., Watson J., O"Farrell N., Ravi N., Kay E., Reynolds J., Ryan E., O"Sullivan J., HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients, Cancer Immunology, Immunotherapy, 66, (7), 2017, p841-850 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dunne M., Dunne M., Ryan C., Nolan B., Nolan B., Tosetto M., Tosetto M., Geraghty R., Winter D., Winter D., O'Connell P., O'Connell P., Hyland J., Hyland J., Doherty G., Doherty G., Sheahan K., Sheahan K., Sheahan K., Ryan E., Ryan E., Fletcher J., Fletcher J., Enrichment of inflammatory IL-17 and TNF-" secreting CD4+ T cells within colorectal tumors despite the presence of elevated CD39+ T regulatory cells and increased expression of the immune checkpoint molecule, PD-1, Frontiers in Oncology, 6, (MAR), 2016, Journal Article, PUBLISHED  TARA - Full Text  DOI
Guinan, E.M., Doyle, S.L., O'Neill, L., Dunne, M.R., Foley, E.K., O'Sullivan, J., Reynolds, J.V., Hussey, J., Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study, Supportive Care in Cancer, 25, (3), 2016, p749 - 756, Journal Article, PUBLISHED  DOI
Flow Cytometric Analysis of Human Small Intestinal Lymphoid Cells in, editor(s)Anthony W Ryan , Celiac Disease Methods and Protocols, Humana Press, 2015, [Dunne MR], Book Chapter, PUBLISHED  DOI

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Award Date
Health Research Award 02/05/2016
Irish Research Council Government of Ireland Postdoctoral Fellow 2014
Dorothy Price medal (NUI Maynooth) 2008
John & Pat Hume Postgraduate Scholarship 2005
Irish Research Council for Science, Engineering & Technology Postgraduate Scholarship 2005
My research involves improving the understanding of roles played by innate immune cells in human health and disease, and translation of this information for therapeutic applications. My research projects to date have focused on elucidating the function of innate lymphocytes, in particular γδ T cells and dendritic cells and their contribution to host immunity in diseases such as coeliac disease and cancer. My current work involves investigating the prognostic potential of immune markers in oesophageal cancer.