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Dr. Derek Doherty

Associate Prof & Head of Immunology (Immunology)

 


A graduate of Trinity College Dublin, I completed a PhD at King's College London and postdoctoral research in the University of Washington, Seattle and University College Dublin before holding lecturing positions at NUI Maynooth and subsequently Trinity College Dublin.
  ADIPOSE-TISSUE   ADJUVANT THERAPY   ADJUVANTS   AUTOIMMUNE DISEASES   B-CELLS   CANCER   CELL-MEDIATED IMMUNE RESPONSES   DENDRITIC CELLS   GAMMA DELTA TCR   HEPATITIS B   HEPATITIS-C   HEPATOCELLULAR-CARCINOMA   HIV   HUMAN LIVER   IMMUNE SYSTEM   IMMUNODEFICIENCY   INFECTIOUS DISEASES   INNATE IMMUNITY   LEUKOCYTE   LIPIDS   LYMPHOCYTES   NATURAL-KILLER-CELLS
 "PhD Scholars Programme in Immunology"
 Health Research Board PhD programme in Molecular Medicine - "From Genes to Function"
  "Combating Diseases of Poverty Consortium"
 Science Foundation Ireland STAR Programme grant,
 Grant from Gilead Sciences, Uxbridge, UK

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Details Date From Date To
Committee member of the Irish Society for Immunology; secretary 2000-2004. 2000 2004
Kennedy, A, Petrasca, A, Doherty, DG, Hennessy, M, Spiers, JP, HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or V gamma 9V delta 2 T lymphocytes, AIDS, 28, (1), 2014, p131-136 , Journal Article, PUBLISHED  DOI
Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, Parat MO, Sessler DI, Shorten G, Singleton P., Consensus statement from the BJA Workshop on Cancer and Anaesthesia., British Journal of Anaesthesia, Aug 7, 2014, ppii: aeu26-, Journal Article, PUBLISHED
Conroy MJ, Mac Nicholas R, Grealy R, Taylor M, Otegbayo JA, O'Dea S, Mulcahy F, Ryan T, Norris S, Doherty DG, Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-γ or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection, Journal of Viral Hepatitis, 10.1111/jvh.12299, (Sep 3), 2014, Journal Article, PUBLISHED
Baird AM, Dockry E, Daly A, Stack E, Doherty DG, O'Byrne KJ, Gray SG, IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer., Frontiers in oncology, 3, 2013, p162-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Dunne, MR, Elliott, L, Hussey, S, Mahmud, N, Kelly, J, Doherty, DG, Feighery, CF, Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease, PLOS ONE, 8, (10), 2013, p76008 , Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Zeng, SG, Ghnewa, YG, O'Reilly, VP, Lyons, VG, Atzberger, A, Hogan, AE, Exley, MA, Doherty, DG, Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro, JOURNAL OF IMMUNOLOGY, 191, (4), 2013, p1666-1676 , Journal Article, PUBLISHED  DOI
Grealy, R, White, M, Stordeur, P, Kelleher, D, Doherty, DG, McManus, R, Ryan, T, Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis, Mediators of Inflammation, 2013, 2013, 164246 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human V"3 T cells., Journal of immunology (Baltimore, Md. : 1950), 191, (1), 2013, p30-4 , Journal Article, PUBLISHED  DOI
Murphy, N, Petrasca, A, Murphy, NM, Reilly, VO, Evans, P, Doherty, DG, Zhu, XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377 , Journal Article, PUBLISHED
Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A, Hepatitis C virus - T-cell responses and viral escape mutations., European journal of immunology, 42, (1), 2012, p17-26 , Journal Article, PUBLISHED  DOI
  

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Our research is aimed at finding out how the immune system can protect against or cause disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in "innate lymphocytes" (natural killer cells, natural killer T cells and gamma/delta T cells), which appear to be "master regulators" of the immune system and which are defective in many infectious and immune-mediated diseases and cancers. In collaboration with clinical colleagues, we are studying innate lymphocytes in patients with hepatitis B and C, HIV, chronic lymphocytic leukaemia, lung cancer, post-operative infection and sepsis, coeliac disease and antibody deficiencies. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of disease.