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Dr. Derek Doherty

Associate Prof & Head of Immunology (Immunology)

 


A graduate of Trinity College Dublin, I completed a PhD at King's College London and postdoctoral research in the University of Washington, Seattle and University College Dublin before holding lecturing positions at NUI Maynooth and subsequently Trinity College Dublin.
  ADIPOSE-TISSUE   ADJUVANT THERAPY   ADJUVANTS   AUTOIMMUNE DISEASES   B-CELLS   CANCER   CELL-MEDIATED IMMUNE RESPONSES   DENDRITIC CELLS   GAMMA DELTA TCR   HEPATITIS B   HEPATITIS-C   HEPATOCELLULAR-CARCINOMA   HIV   HUMAN LIVER   IMMUNE SYSTEM   IMMUNODEFICIENCY   INFECTIOUS DISEASES   INNATE IMMUNITY   LEUKOCYTE   LIPIDS   LYMPHOCYTES   NATURAL-KILLER-CELLS
 "PhD Scholars Programme in Immunology"
 Health Research Board PhD programme in Molecular Medicine - "From Genes to Function"
 Science Foundation Ireland STAR Programme grant,
  "Combating Diseases of Poverty Consortium"
 Grant from Gilead Sciences, Uxbridge, UK

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Details Date From Date To
Committee member of the Irish Society for Immunology; secretary 2000-2004. 2000 2004
Arduini S, Dunne J, Conlon N, Feighery C, Doherty D.G, Mucosal-associated invariant T cells are depleted and functionally altered in patients with common variable immunodeficiency, Clinical Immunology, 176, 2017, p23 - 30, Notes: [Export Date: 20 March 2017], Journal Article, PUBLISHED  DOI  URL
Doherty D.G, Immunity, tolerance and autoimmunity in the liver: A comprehensive review, Journal of Autoimmunity, 66, 2016, p60 - 75, Notes: [Cited By :10 Export Date: 20 March 2017], Journal Article, PUBLISHED  DOI  URL
Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338 , Journal Article, PUBLISHED  DOI  URL
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885 , Journal Article, PUBLISHED  DOI
Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 , Journal Article, PUBLISHED  DOI
Maher C.O, Dunne K, Comerford R, O'Dea S, Loy A, Woo J, Rogers T.R, Mulcahy F, Dunne P.J, Doherty D.G, Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by V-1 T cells, Journal of Immunology, 194, (12), 2015, p5953 - 5960, Notes: [Export Date: 23 July 2015], Journal Article, PUBLISHED  DOI  URL
Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780, Notes: [Export Date: 23 July 2015], Journal Article, PUBLISHED  DOI  URL
Conroy M.J, Mac Nicholas R, Taylor M, O'dea S, Mulcahy F, Norris S, Doherty D.G, Increased frequencies of circulating IFN---producing V-1+ and V-2+ -- T cells in patients with asymptomatic persistent Hepatitis B virus infection, Viral Immunology, 28, (4), 2015, p201 - 208, Notes: [Export Date: 23 July 2015], Journal Article, PUBLISHED  DOI  URL
Conroy M.J, Mac Nicholas R, Taylor M, O'dea S, Mulcahy F, Norris S, Doherty D.G, Increased frequencies of circulating IFN-γ-producing VÎŽ1<sup>+</sup> and VÎŽ2<sup>+</sup> γΎ T cells in patients with asymptomatic persistent Hepatitis B virus infection, Viral Immunology, 28, (4), 2015, p201 - 208, Notes: [Cited By :1 Export Date: 20 March 2017], Journal Article, PUBLISHED  DOI  URL
Tyler C., Doherty D., Moser B., Eberl M., Human Vγ9/VÎ"2 T cells: Innate adaptors of the immune system, Cellular Immunology, 296, (1), 2015, p10-21 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Our research is aimed at finding out how the immune system can protect against or cause disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in "innate lymphocytes" (natural killer cells, natural killer T cells and gamma/delta T cells), which appear to be "master regulators" of the immune system and which are defective in many infectious and immune-mediated diseases and cancers. In collaboration with clinical colleagues, we are studying innate lymphocytes in patients with hepatitis B and C, HIV, chronic lymphocytic leukaemia, lung cancer, post-operative infection and sepsis, coeliac disease and antibody deficiencies. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of disease.