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Dr. Derek Nolan

Associate Professor (Biochemistry)
BIOMEDICAL SCIENCES INSTITUTE

DIRECTOR OF CMA (Centre for Microscopy & Analysis)


I have worked on African trypanosomes, which cause human sleeping sickness, for twenty years. As a PhD student I investigated the bioenergetics of T. brucei in Paul Voorheis' laboratory at Trinity College Dublin. Subsequently, I moved to Brussels in 1992, as an EMBO fellow, to join the group of Etienne Pays to study the expression and function of surface proteins in trypanosomes. In 1994 I was awarded a Marie Curie fellowship and focused on the problem of endocytosis in trypanosmes. Trypanosomes are absolutely dependent on their hosts for a supply of iron and lipoproteins and this traffic is highly polarized and extremely rapid in bloodstream forms of the parasite. In the summer of 2001 I was awarded a Senior Fellowship by the Trust to characterize proteins from the flagellar pocket and endocytic pathway in African trypanosomes. These parasitic protozoans cause sleeping sickness in humans and related diseases in domestic animals. Human sleeping sickness is invariably fatal unless treated. Of the four drugs currently employed to treat infections, resistance to two has emerged and the drug of choice, suramin, is suitable only in early stages. Trypanosomiasis is also considered one of the greatest health constraint to livestock productivity in sub-Saharan Africa with costs ranging between $2 and $5 billion annually. African trypanosomes are clearly a global health issue and are an enormous medical, veterinary and economic burden on some of the poorest regions on earth. Apart from their utilitarian interest, trypanosomes have proved to have great intrinsic scientific interest. These unicellular eukaryotes have evolved very differently from the better studied organisms, e.g. bacteria, yeast and metazoans, on which the foundations of biology have been built. Some of the most basic cellular and genetic pathways have developed very differently in trypanosomes but other processes first described and characterized in trypanosomes are now known to be important in mammalian cells. From the nucleus to the plasma membrane trypanosomes have provided fascinating insights including unusual genome organisation, pol I transcription of coding genes, expression sites and novel nuclear substructures, RNA editing, mitochondrial repression/activation, compartmentalization of glycolysis, GPI anchors, unusual organisation of surface proteins and the endocytic pathway, polarized cytoskeletons, golgi duplication and many other phenomena. By any criterion, whether biochemical, molecular or cellular, trypanosomes have more than punched their weight in terms of a contribution to our understanding of eukaryotic biology. osomes and returned to Trinity College Dublin at the end of 2001
  ACIDIC REPETITIVE PROTEIN   AFRICAN TRYPANOSOMES   BLOOD-STREAM FORMS   CELL-SURFACE   CONCANAVALIN-A   CROSS-LINKING   GPI-ANCHORED PROTEINS   LIPOPHILIC CATION   MEMBRANE-POTENTIAL CHANGES   MITOGENIC STIMULATION   NEURO-BLASTOMA   Parasitology   PH GRADIENTS   PHOSPHATIDYLINOSITOL MEMBRANE ANCHOR   PLASMA-MEMBRANE   PROCYCLIC FORMS   PROTON-MOTIVE FORCE   SACCHAROMYCES-CEREVISIAE   SECONDARY STRUCTURE   STREPTOCOCCUS-LACTIS   TRANSFERRIN RECEPTOR
 Polarity and function of actin in vesicle traffic in African trypanosomes
 Characterization of glycoproteins from the flagellar pocket and endocytic pathway in African trypanosomes: a new paradigm for protein trafficking in a highly polarized cell.

Details Date
Reviewer for European Journal of Biochemistry; EMBO Journal; Molecular and Biochemical Parasitology; Parasitology Today; J. Cell Science; Molecular Microbiology
Grant reviewer for: [1] - The National Science Foundation, Washington, D.C. 20550, U.S.A. [2] - The Wellcome Trust (UK), FNRS (Belgium), BBSRC (UK)
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Medium
Spanish Basic Basic Basic
Details Date From Date To
Member of the Biochemical Society London 2014
Doherty W, James J, Evans P, Martin L, Adler N, Nolan D, Knox A. , Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones., Organic & Biomolecular Chemistry, 12, (38), 2014, p12(38):756 - 7571, Journal Article, PUBLISHED
Lecordier L, Uzureau1 P, Tebabi1 P, Pérez-Morga1 D, Nolan DP , Schumann Burkard G, Roditi I and Epays E , Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum. , Molecular Microbiology, 94, 2014, p625 - 636, Journal Article, PUBLISHED
Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F., TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei., Nucleic Acids Research, 43, 2014, p637-44 - 644, Journal Article, PUBLISHED  TARA - Full Text
Woods, K, a'Bhaird, NN, Dooley, C, Perez-Morga, D, Nolan, DP, Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei, PLOS ONE, 8, (1), 2013, e52846-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Greene, L.M., Nolan, D.P., Regan-Komito, D., Campiani, G., Williams, D.C., Zisterer, D.M., Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells, International Journal of Oncology, 43, (3), 2013, p927-935 , Journal Article, PUBLISHED  DOI
Uzureau, P., Uzureau, S., Lecordier, L., Fontaine, F., Tebabi, P., Homblé, F., Grélard, A., Zhendre, V., Nolan, D.P., Lins, L., Crowet, J.-M., Pays, A., Felu, C., Poelvoorde, P., Vanhollebeke, B., Moestrup, S.K., Lyngsø, J., Pedersen, J.S., Mottram, J.C., Dufourc, E.J., Pérez-Morga, D., Pays, E., Mechanism of Trypanosoma brucei gambiense resistance to human serum, Nature, 501, (7467), 2013, p430-434 , Journal Article, PUBLISHED  DOI
Dunny E, Doherty W, Evans P, Malthouse JP, Nolan D, Knox AJ., Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation., Journal of Medicinal Chemistry, 56, (17), 2013, p6638 - 6650, Journal Article, PUBLISHED
Greene, LM, O'Boyle, NM, Nolan, DP, Meegan, MJ, Zisterer, DM, The vascular targeting agent Combretastatin-A4 directly induces autophagy in adenocarcinoma-derived colon cancer cells, BIOCHEMICAL PHARMACOLOGY, 84, (5), 2012, p612-624 , Journal Article, PUBLISHED  DOI
Diana Spitznagel, John F. O'Rourke, Neal Leddy, Orla Hanrahan, Derek P. Nolan, Identification and Characterization of an Unusual Class I Myosin Involved in Vesicle Traffic in Trypanosoma brucei, PLoS ONE, 5, (8), 2010, pe12282 , Journal Article, PUBLISHED  TARA - Full Text
Diana Spitznagel, Charles Ebikeme, Marc Biran, Nóirín Nic a' Bháird, Frédéric Bringaud, Gary T. M. Henehan and Derek P. Nolan, Alanine aminotransferase of Trypanosoma brucei- a key role in proline metabolism in procyclic life forms, FEBS Journal, 276, (23), 2009, p7187 - 7199 , Journal Article, PUBLISHED  DOI
  

Page 1 of 6
Nolan, D.P. and Pays, E., Expression and function surface proteins in Trypanosoma brucei, The trypanosome surface Proceedings of the third Francqui colloquium, Francqui Scientific library De Boeck Brussels, 1999, pp5 - 51, Conference Paper, PUBLISHED

  

Award Date
EMBO long term Fellowship 1992
Marie Curie Fellowship 1994
. Expression and function of surface proteins in protozoan parasites. Endocytosis, protein traffic and flagellar pocket function.. Parasite Bioenergetics . regulation and function of actin cytoskeleton. . Molecular and cell biology of the African trypanosome Trypanosoma brucei. . Vesicular traffic and the actin cytoskeleton in T. brucei.