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Dr. David Hoey

Associate Professor (Mechanical & Manuf. Eng)

Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Bioengineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.
  BIOMATERIALS   BIOMECHANICS   Biomechanics, Biomedical Engineering   BONE ABNORMALITIES   BONE ADAPTATION   BONE CEMENT   BONE MASS   BONE METASTASIS   BONE REGENERATION   bone remodelling and repair   CELL BIOMECHANICS   MECHANOBIOLOGY   MESENCHYMAL STEM CELLS   Promotion of Bone Health throgh Exercise   Stem Cell Biology
 Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
 Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis

Details Date From Date To
Engineers Ireland (Treasurer of the Biomedical Division) 2006 -
Orthopedic Research Society 2010 -
Marie-Curie Fellow Association 2015 -
Flanagan AM, Stavenschi E, Basavaraju S, Gaboriau D, Hoey DA, Morrison CG, Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification., 2017, Journal Article, PUBLISHED
Stavenschi, E., Labour, M.-N., Hoey, D.A., Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration, Journal of Biomechanics, 55, 2017, p99-106 , Journal Article, PUBLISHED
Sankalp Agarwal, Mathieu Riffault, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal, Biomimetic Hyaluronic Acid-Lysozyme Composite Coating on AZ31 Mg Alloy with Combined Antibacterial and Osteoinductive Activities, ACS Biomaterials Science & Engineering, 3, (12), 2017, p3244--3253 , Journal Article, PUBLISHED
Johnson, G.P., English, A.-M., Cronin, S., Hoey, D.A., Meade, K.G., Fair, S., Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine, Biology of Reproduction, 97, (2), 2017, p302-312 , Journal Article, PUBLISHED
Labour MN, Riffault M, Christensen ST, Hoey DA, TGFß1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner., 2016, Journal Article, PUBLISHED
O'Connor Mooney R, Davis NF, Hoey D, Hogan L, McGloughlin TM, Walsh MT, On the Automatic Decellularisation of Porcine Aortae: A Repeatability Study Using a Non-Enzymatic Approach., 2016, Journal Article, PUBLISHED
Coyle, S., Lenehan, B., Hoey, D.A., Electromechanics of bone: Mechanobiological considerations, Electrically Active Materials for Medical Devices, 2016, p511-528 , Journal Article, PUBLISHED
Eichholz, K.F., Hoey, D.A., The Role of the Primary Cilium in Cellular Mechanotransduction: An Emerging Therapeutic Target, Mechanobiology: Exploitation for Medical Benefit, 2016, p61-73 , Journal Article, PUBLISHED
Brady RT, O'Brien FJ, Hoey DA, Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation., Biochemical and biophysical research communications, 459, (1), 2015, p118 - 123, Journal Article, PUBLISHED  TARA - Full Text
Chen JC, Hoey DA, Chua M, Bellon R, Jacobs CR, Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Journal Article, PUBLISHED  TARA - Full Text  DOI

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Award Date
Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz) 2016
Marie-Skłodowska Curie COFUND Excellence award 2015
University of Limerick Award for Research Excellence (Early Career) 2014
European Research Council Starting Grant 2013
Orthopaedic Biomechanics and Mechanobiology Mechanotransduction mechanisms Biomaterials Primary Cilia Cancer Mechanobiology