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Dr. Colm Cunningham

Associate Professor - Neuroscience (Biochemistry)

Associate Professor - Neuroscience (Trinity Inst. of Neurosciences (TCIN))

  Ageing, Older People and Healthcare   Aging/Gerontology   Alzheimer's Disease   Amyotrophic Lateral Sclerosis (ALS)   Animal Models   Brain   Dementia   Dementia/ Alzheimer's Disease   Depression   Emotional/Mental Health--Geriatric   Inflammation   Neurodegeneration   Neurodegenerative Diseases/Disorders   Neurological Disorders   Parkinson's Disease   Senile Dementia   Stress
 Towards and understanding of infection-induced delirium
 Reconciling Cholinergic and inflammatory hypotheses of delirium: acute and lasting effects of systemic inflammation on chronic neurodegeneration
 Neuroinflammatory and cognitive consequences of losing cholinergic anti-inflammatory tone in the forebrain
 Fever & the brain in autism: temperature vs. inflammatory effects
 The impact of acute systemic inflammation upon CSF and blood biomarkers of brain inflammation and injury in dementia: a study in acute hip fracture and memory clinic patients

Details Date
As a member of the Association Executive I have contributed to discussions leading to a consensus adopted by the European Delirium Association and the American Delirium Society (BMC Medicine 201412:141 DOI: 10.1186/s12916-014-0141-2) that with respect to "The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer". I was also part of an international panel of experts gathered to write a definitive report on the "Intensive Care Medicine Research Agenda on Delirium" for publication in INTENSIVE CARE MEDICINE. I am an editorial board member of 2 journals: Brain Behavior and Immunity. Journal of Neuroinflammation.
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Italian Basic Basic Basic
Details Date From Date To
Society for Neuroscience 2005 2015
European Delirium Association 2008 2017
Psychoneuroimmunology Research Society 2009 2014
Mamad, O. and Islam, M.N. and Cunningham, C. and Tsanov, M., Differential response of hippocampal and prefrontal oscillations to systemic LPS application, Brain Research, 1681, 2018, p64-74 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Rolandi, E. and Cavedo, E. and Pievani, M. and Galluzzi, S. and Ribaldi, F. and Buckley, C. and Cunningham, C. and Guerra, U.P. and Musarra, M. and Morzenti, S. and Magnaldi, S. and Patassini, M. and Terragnoli, F. and Matascioli, L. and Franzoni, S. and Annoni, G. and Carnevali, L. and Bellelli, G. and Frisoni, G.B., Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study, Neurobiology of Aging, 61, 2018, p93-101 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Hennessy E, Gormley S, Lopez-Rodriguez A.B, Murray C, Murray C, Cunningham C, Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration, Brain, Behavior, and Immunity, 59, 2017, p233 - 244, Notes: [Export Date: 10 January 2017], Journal Article, PUBLISHED  DOI  URL
Davis DH, Muniz-Terrera G, Keage HA, Stephan BC, Fleming J, Ince PG, Matthews FE, Cunningham C, Ely EW, MacLullich AM, Brayne C, Epidemiological Clinicopathological Studies in Europe (EClipSE) Collaborative Members., Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies., JAMA Psychiatry, 74, (3), 2017, p244-251 , Journal Article, PUBLISHED  DOI
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039 , Journal Article, PUBLISHED  DOI
Pandharipande, P.P. and Ely, E.W. and Arora, R.C. and Balas, M.C. and Boustani, M.A. and La Calle, G.H. and Cunningham, C. and Devlin, J.W. and Elefante, J. and Han, J.H. and MacLullich, A.M. and Maldonado, J.R. and Morandi, A. and Needham, D.M. and Page, V.J. and Rose, L. and Salluh, J.I.F. and Sharshar, T. and Shehabi, Y. and Skrobik, Y. and Slooter, A.J.C. and Smith, H.A.B., The intensive care delirium research agenda: a multinational, interprofessional perspective, Intensive Care Medicine, 43, (9), 2017, p1329-1339 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Carroll, E.C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H.B.T., Mansouri, S., McEntee, C.P., Lambe, E., Agger, E.M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K.A., Bowie, A.G., Lavelle, E.C., The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons, Immunity, 44, (3), 2016, p597 - 608, Journal Article, PUBLISHED  DOI
Hennessy, E; Griffin E; Cunningham C, Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL-1β and TNF-α, Journal of Neuroscience, 35, (22), 2015, p8411 - 8422, Journal Article, PUBLISHED  URL
Renata Reis, Edel Hennessy, Caoimhe Murray, Éadaoin W. Griffin and Colm Cunningham, At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. , Neuropathology and Applied Neurobiology, 41 , (6), 2015, p780 - 797, Journal Article, PUBLISHED  DOI
Davis DH, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, Brayne C, Rahkonen T, Sulkava R, Sanderson DJ, Rawlins JN, Bannerman DM, MacLullich AM, Cunningham C, Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium., The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 23, (4), 2015, 403-415 , Journal Article, PUBLISHED  TARA - Full Text  DOI

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Donal Skelly, Eadaoin W Griffin, Carol Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Nicholas Rawlins, David Bannerman, Colm Cunningham, Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms, bioRxiv, 2017, Dataset, PUBLISHED
Colm Cunningham, European Delirium Association annual meeting 2017, Oslo, Autumn, 2017, Invited Talk, APPROVED
Colm Cunningham, American Delirium Society Annual Meeting, Nashville, June, 2016, Invited Talk, PRESENTED
Colm Cunningham, Immunology research series, University of Cambridge, October, 2016, Invited Talk, PRESENTED
Colm Cunningham, Neurosciences in Intensive Care Symposium, Pasteur institute, Paris, June, 2016, Invited Talk, PRESENTED
Colm Cunningham, Keynote lecture, European Delirium Associaton/British Geriatric Society Meeting, London, September, 2015, BGS/EDA, Invited Talk, PRESENTED
Colm Cunningham, British Association for Psychopharmacology Conference, Bristol, August, 2015, BAP, Invited Talk, PRESENTED
Colm Cunningham, "Delirium in Older Adults: Finding Order in the Disorder", , NIH, Bethesda, Maryland, USA, February, 2014, National Institute of Aging & American Geriatrics Society, Invited Talk, PRESENTED
Robert Dantzer(ed.), Cytokines in the ageing brain, Trends in Neurosciences, Arcachon, France, 25, ((11)), June 2002, Elsevier, 2002, 546-547 p, Notes: [Author list: Colm Cunningham, Jan-Pieter Konsman and Tammy Cartmell], Proceedings of a Conference, PUBLISHED


Award Date
Wellcome Trust Research Career Development Fellowship 2006
Wellcome Trust Senior Research Fellowship 2010