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Dr. Sinead Cristin Corr

Assistant Professor (Microbiology)


     BACTERIAL INFECTION   EPITHELIAL PERMEABILITY   GUT BARRIER FUNCTION   IBD   Infection and immunity   INFLAMMATION   Intestinal Barrier Function   INTESTINAL EPITHELIAL-CELLS   INTESTINAL INFECTIONS   INTESTINAL INFLAMMATION   MICROBIOTA   miRNA   Molecular basis to inflammation and innate immunity   MOUSE MODELS   Probiotic
Details Date From Date To
Adjunct Faculty Member APC Microbiome Ireland 2017 Present
Microbiology Society 2002 Present
Irish Society of Immunology 2008 Present
Irish Epithelial Physiology Group 2015 Present
Irish Society of Gastroenterology 2006 Present
Dublin Academy of Pathogenomics and Infection Biology 2015 Present
American Gastroenterological Association 2002 2014
Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4 , Journal Article, PUBLISHED
Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 2018, pdoi:10.1093/ecco-jcc/jjy038 , Journal Article, PUBLISHED
Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Masters SL, NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease., Nature communications, 2018, Journal Article, PUBLISHED
Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.], Book Chapter, PUBLISHED  URL
Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016, Conference Paper, PUBLISHED
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379, Journal Article, PUBLISHED  TARA - Full Text  URL
Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13, Journal Article, PUBLISHED  DOI  URL
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 , Journal Article, PUBLISHED  DOI
  

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Award Date
Frontiers for the Future, SFI 2020
Travel Award: INRA-Gut Microbiology, France 2004
Travel Award:American Society of Microbiologists & International Union of Microbiological Societies (IUMS) Congresses U.S.A. 2005
Travel Award: Microbiology Society, IUMS Congress, U.S.A. 2005
Travel Award: FEMS, Microbiology Symposium, Spain 2006
Travel Award: INRA-Gut Microbiology, Scotland 2006
Travel Award,, Fundacao Oswaldo Cruz, Rio de Janeiro, Brasil 2013
Travel Award: Microbiology Society Meeting, Dublin 2006
Starting Investigator Research Grant, SFI 2011
Crohn's and Colitis Foundation of America, Litwin IBD Pioneer Award 2016
Aurora Leadership Development Programme, Advance HE 2019
Irish Representative, Microbiology Society "Young Microbiologist of the Year" British Isles. 2007
Irish Society of Gastroenterology Spring Meeting, Ireland, Awarded best talk. 2007
Rowett Research Institute-Institut National de la Recherche Agronomique, Gut Microbiology Symposium, Aberdeen, Scotland, Awarded best talk. 2006
Society for General Microbiology, Dublin, Awarded best talk. 2006
Presidents Fund Award, Society for General Microbiology 2004