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Dr. Sinead Cristin Corr

Assistant Professor (Microbiology)


     BACTERIAL INFECTION   EPITHELIAL PERMEABILITY   GUT BARRIER FUNCTION   IBD   Infection and immunity   INFLAMMATION   Intestinal Barrier Function   INTESTINAL EPITHELIAL-CELLS   INTESTINAL INFECTIONS   INTESTINAL INFLAMMATION   MICROBIOTA   miRNA   Molecular basis to inflammation and innate immunity   MOUSE MODELS   Probiotic
Details Date From Date To
Adjunct Faculty Member APC Microbiome Institute Present
Microbiology Society 2002 Present
Irish Society of Immunology 2008 Present
Irish Epithelial Physiology Group Present
Irish Society of Gastroenterology 2006 Present
American Gastroenterological Association
Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.], Book Chapter, PUBLISHED  URL
Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016, Conference Paper, PUBLISHED
Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368-79 , Journal Article, PUBLISHED  TARA - Full Text  URL
Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13, Journal Article, PUBLISHED  DOI  URL
Westermann, C., Gleinser, M., Corr, S.C., Riedel, C.U., A critical evaluation of bifidobacterial adhesion to the host tissue, Frontiers in Microbiology, 7, (AUG), 2016, Journal Article, PUBLISHED
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 , Journal Article, PUBLISHED  DOI
Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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My research interests lie at the host-microbe interface within the gastrointestinal (GI) tract, with an overall focus on microbial modulation of gut immunity. This work aims to understand the molecular mechanisms which govern the interplay that occurs between pathogenic bacteria, the microbiota and the host organism, namely the epithelial barrier and innate immunity. The subsequent maintenance of health or development of disease is of particular interest. Gastroenteritis, including bacterial infectious diseases, are a major cause of morbidity and mortality worldwide, while inflammatory bowel diseases (IBDs) affect over 2 million people in Europe. My work hopes to characterize the host mechanisms which mediate gut health in response to infectious and resident microbes and to determine how microbes can alter this intestinal homeostasis giving rise to disease. This will enable strategic manipulation of intestinal epithelial defences or probiotic treatment strategies with the ultimate goal of reducing the severity of intestinal infectious and inflammatory diseases. Key Themes: .Gut barrier: Molecular mechanisms governing gut homeostasis and disease. .Microbiota: Microbiota-Host-Epithelium Interaction Anti-microbial and anti-inflammatory activity of probiotics. .Infection & Immunity: Microbial determinants of infection. Innate Immunity to infection. Gut Barrier: The epithelial cells lining the GI tract form a barrier between the body and the luminal environment which not only contains nutrients and commensal microbiota, but also potentially harmful microorganisms and toxins. This epithelial barrier is pivotal to intestinal health or disease, with loss of barrier integrity or "leaky gut" being implicated in a range of diseases including infectious enterocolitis and IBD. Epithelial cells express pattern recognition receptors (PRRs) which orchestrate mucosal defences during infection and respond to gut commensals to maintain intestinal wellbeing. As a result, the GI epithelium is a crucial site of immune regulation and the integrity of this barrier determines health or development of disease. My work investigates the host immune mechanisms and microbial factors which control the functional integrity of the gut epithelial barrier. Microbiota: The gut microbiota presents a significant barrier that must be overcome for a pathogen to initiate an infection or inflammatory onslaught. The relationship between the host and its microbiota is largely a beneficial one, with members of the microbiota being instrumental to human physiology and wellbeing. Microbial presence and activity influences the function of intestinal defences, and has a key role in improving digestive function, in the reduction of chronic inflammation, and in hastening recovery from intestinal disease. However this relationship can become detrimental due to disturbances including alterations in diet and antibiotic use, and the resulting microbial dysbiosis has been linked to infection, IBD, diabetes and obesity. My research focusses on the host-microbiota dialogue, investigating the signalling interactions between the host and its microbiota which mediate immune-inflammatory responses. It hopes to decipher to what extent the microbiota can modulate the intestinal epithelial barrier and inflammation, and how members of the microbiota can be used to directly inhibit infection by bacterial pathogens. Infection&Immunity: Work to date has focussed on understanding the intestinal phase of infection with gut pathogens, specifically Listeria monocytogenes and Salmonella Typhimurium. We are interested in the characterization of bacterial virulence factors involved in infection of host cells, and in deciphering the host mechanisms to combat infection. Furthermore, the strategies evolved by bacteria to subvert these host defence mechanisms and immune responses enabling spread within the host in a research focus.