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Professor Stephen Connon

Professor in Synthetic Chemistry (Chemistry)
BIOMEDICAL SCIENCES INSTITUTE


  CANCER CHEMOTHERAPY   CATALYSIS   CYCLIN   KINASE COMPLEX   ORGANIC-SYNTHESIS   ORGANOMETALLICS   TETRACYCLINE
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
German Medium Medium Medium
Details Date From Date To
Council Member of the Instite of Chemistry of Ireland 2003 2005
Member of the RSC Ireland Committee 2005 -
Claveau, R. and Twamley, B. and Connon, S.J., Dynamic kinetic resolution of bis-aryl succinic anhydrides: Enantioselective synthesis of densely functionalised γ-butyrolactones, Chemical Communications, 54, (26), 2018, p3231-3234 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Craig, R. and Sorrentino, E. and Connon, S.J., Enantioselective Alkylation of 2-Oxindoles Catalyzed by a Bifunctional Phase-Transfer Catalyst: Synthesis of (â^')-Debromoflustramine B, Chemistry - A European Journal, 24, (18), 2018, p4528-4531 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Delany, E.G. and Connon, S.J., Highly chemoselective intermolecular cross-benzoin reactions using an: Ad hoc designed novel N-heterocyclic carbene catalyst, Organic and Biomolecular Chemistry, 16, (5), 2018, p780-786 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039 , Journal Article, PUBLISHED  DOI
Kumar, V. and Connon, S.J., Direct, efficient NHC-catalysed aldehyde oxidative amidation:: In situ formed benzils as unconventional acylating agents, Chemical Communications, 53, (73), 2017, p10212-10215 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Trujillo, C. and Rozas, I. and Botte, A. and Connon, S.J., A DFT mechanistic study of the organocatalytic asymmetric reaction of aldehydes and homophthalic anhydride, Chemical Communications, 53, (63), 2017, p8874-8877 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Manoni, F. and Farid, U. and Trujillo, C. and Connon, S.J., Catalytic asymmetric Tamura cycloadditions involving nitroalkenes, Organic and Biomolecular Chemistry, 15, (6), 2017, p1463-1474 , Notes: [cited By 2], Journal Article, PUBLISHED  DOI
Roucan, M. and Kielmann, M. and Connon, S.J. and Bernhard, S.S.R. and Senge, M.O., Conformational control of nonplanar free base porphyrins: Towards bifunctional catalysts of tunable basicity, Chemical Communications, 54, (1), 2017, p26-29 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cronin SA, Gutiérrez Collar A, Gundala S, Cornaggia C, Torrente E, Manoni F, Botte A, Twamley B, Connon SJ, The first catalytic asymmetric cycloadditions of imines with an enolisable anhydride., Organic & biomolecular chemistry, 14, (29), 2016, p6955-9 , Journal Article, PUBLISHED  DOI
Cornaggia, C., Gundala, S., Manoni, F., Gopalasetty, N., Connon, S.J., Catalytic formal cycloadditions between anhydrides and ketones: Excellent enantio and diastereocontrol, controllable decarboxylation and the formation of adjacent quaternary stereocentres, Organic and Biomolecular Chemistry, 14, (11), 2016, p3040-3046 , Journal Article, PUBLISHED  DOI
  

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The design and synthesis of novel chiral organocatalysts (and immobilised versions thereof) for asymmetric transformations. Asymmetric bifunctional organocatalysis. Synthesis of novel cyclin-dependant kinase (CDK) inhibitors. Design of novel tetracycline derivatives to combat bacterial resistance. Novel synthetic methodology, including the scope expansion of several important carbon-carbon bond-forming reactions such as the asymmetric Baylis-Hillman reaction and ketone trifluoromethylation. The design of novel fast initiating olefin metathesis catalysts.