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Dr. Conor Buckley

Assistant Professor (Mechanical & Manuf. Eng)

 


On completion of a PhD degree in 2007 in the area of scaffolds and bone tissue engineering, Dr. Buckley worked as a senior postdoctoral fellow in the fields of cartilage regenerative medicine and mechanobiology- developing new strategies, medical devices and techniques for stem cell based repair. In 2009, Dr. Buckley was awarded an SFI fellowship to work in the mesenchymal stem cell group at the Leeds Institute of Molecular Medicine, UK focusing on isolation, enrichment and characterisation of mesenchymal stem cells (MSCs) from different tissue sources for regenerative medicine purposes. His current main research area focuses on the development of strategies to regenerate the intervertebral disc (IVD) and articular cartilage. Other research areas include design and development of bioreactor based systems, tissue engineering, nutrient micro-environments, biomaterial interactions and 3D scaffold construct technology. Dr. Buckley was appointed Assistant Professor (Tissue Engineering) in September 2011. He is currently module coordinator for 4B1 Mechanics of Solids, 4B20 Biomaterials, Biomechanics (MSc Bioengineering) and Cell & Tissue (MSc Bioengineering).
  Biomaterials   Tissue Engineering
 Isolation and characterization of different mesenchymal stem cell populations
 Natural ECM Derived Injectable Microparticles for Regeneration of the Intervertebral Disc (DiscReGen)
 Injectable Hydrogel Composites for Stem Cell Repair of the Nucleus Pulposus

Details Date
Visceral- "Living Art Experiment", TCD Science Gallery, Ireland.
Exhibiting demonstrating ten years of SymbioticA's challenging work at the frontier between fine art and biotechnology revolving around the nature of the living and non-living.
Contribution: Chief Scientific Advisor.
28th Jan- 25th Feb 2011
4Th UK Stem Cell Meeting, Leeds University. Contribution: Invited committee member 2010
Bioengineering in Ireland (BINI), Grand Hotel, Malahide Dublin.
Contribution: Organising committee
Jan 22-23rd, 2010
"Transformations", TCD Science Gallery, Ireland, HEA celebration of 10 years of PRTLI funding.
Contribution: Co-organised the "Exploring Bioengineering" exhibit demonstrating the research undertaken by TCBE since its inception.
27th Nov- 2nd Dec 2008
Techno Threads- "Victimless leather", TCD Science Gallery, Ireland.
Contribution: Setup, installation and management of exhibition piece which demonstrated how tissue cultures could be used to create semi-living clothes
26th Apr- 25th Jul 2008
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Details Date From Date To
Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2009 Present
European Society of Biomechanics (ESB) 2009 Present
Orthopaedic Research Society (ORS) 2009 Present
Guillaume, O., Daly, A., Lennon K., Gansau J., Buckley S.F. and Buckley, C.T., Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus - Effect of TGF-β3 supplementation and oxygen culture conditions, Acta Biomaterialia, 2014, Journal Article, IN_PRESS  TARA - Full Text
Carroll, S.F., Buckley, C.T., Kelly, D.J., Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad. , Journal of Biomechanics, 2014, Journal Article, IN_PRESS  TARA - Full Text
Kearney C.M., Buckley C.T., Jenner F and Brama P.A.J. , Elasticity and Breaking Strength of Synthetic Suture Materials Incubated in Various Equine Physiological and Pathological Solutions, Equine Veterinary Journal , 2014, Journal Article, IN_PRESS
O'heireamhoin S, Buckley CT, Jones E, McGonagle D, Mulhall KJ, Kelly DJ, Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering., Tissue engineering. Part C, Methods, 19, (2), 2013, p117-127 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mesallati, T., Buckley, C.T., Nagel, T., Kelly, D.J., Scaffold architecture determines chondrocyte response to externally applied dynamic compression. , Biomechanics and Modeling in Mechanobiology, 12, (5), 2013, p889-899 , Notes: [PMID: 23160843 ], Journal Article, PUBLISHED  DOI
Sheehy EJ, Vinardell T, Buckley CT, Kelly DJ, Engineering osteochondral constructs through spatial regulation of endochondral ossification., Acta biomaterialia, 9, (3), 2013, p5484-5492 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Liu, Y., Buckley, C.T., Mulhall, K.J., Kelly, D.J., Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells, Biomaterials Science, 1, (7), 2013, p745-752 , Notes: [ ], Journal Article, PUBLISHED  TARA - Full Text  DOI
Cox G., Boxhall S., Giannoudis P.V., Buckley C.T., Roshdy T., Churchman S.M., McGonagle D. and Jones E.: , High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long-bones, Bone, 50, (2), 2012, p510-517 , Journal Article, PUBLISHED  TARA - Full Text
C.T. Buckley, D.J. Kelly, Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs, Journal of the Mechanical Behavior of Biomedical Materials, 11, 2012, p102-111 , Journal Article, PUBLISHED  TARA - Full Text  DOI
A.J. Steward, S.D. Thorpe, C.T. Buckley, D.R. Wagner, D.J. Kelly, Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure, Acta Biomaterialia, 8, (6), 2012, p2153-2159 , Journal Article, PUBLISHED  TARA - Full Text  DOI
  

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Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010, Notes: [ ], Oral Presentation, PRESENTED
Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010, Oral Presentation, PRESENTED
Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 15th Annual Conference of the Section of Bioengineering, Limerick, Ireland, edited by McGloughlin and M. Walsh , 2009, Oral Presentation, PRESENTED
Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 3rd UK Mesenchymal Stem Cell Meeting, Sheffield, UK, 2009, Poster, PRESENTED
Buckley C.T. & O'Kelly K.U., Fabrication of a hydroxyapatite scaffold with a tri-modal pore distribution for bone tissue engineering, Proceedings of the 12 Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, edited by McHugh P.E., O'Mahoney, D. and Fitzpatrick D. , 2006, pp89 , Oral Presentation, PRESENTED
Buckley C.T., Prina-Mello A., O'Kelly K.U., Development of biodegradable elastomeric scaffolds for mechanobiology investigations, Proceedings of the 11th Annual Conference of the Section of Bio-engineering of the Royal Academy of Medicine in Ireland, Galway, edited by FitzPatrick D.P. and Senouci M. , 2005, pp13-, Oral Presentation, PRESENTED
Regular Scaffold Fabrication Techniques for Investigations in Tissue Engineering in, editor(s)P.J. Prendergast & P.E McHugh , Topics in Biomechanical Engineering, 2004, pp147 - 166, [C.T. Buckley and K.U. O'Kelly], Book Chapter, PUBLISHED
Buckley C.T. and O'Kelly K.U., A New technique for fabricating regular 3D scaffolds for bone tissue engineering applications, Proceedings of the tenth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Limerick, edited by D.P. Fitzpatrick, B.A.O. McCormack and T.M. McGlouhlin , 2004, pp19-, Oral Presentation, PRESENTED
Buckley C.T. & O'Kelly K.U., Direct permeability measurements in cross-species trabecular bone with varying anatomic location, Proceedings of the 9th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Cavan, edited by D.P. FitzPatrick, B.A.O. McCormack and D. McCormack , 2003, pp19-, Oral Presentation, PRESENTED

  

Award Date
. European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate. Thorpe S.D., Buckley C.T., Steward A. and Kelly D.J. 2012
. Engineers Ireland Biomedical Research Medal 2012: Engineering Osteochondral Constructs through Spatial Regulation of Endochondral Ossification. Sheehy E.J., Vinardell T., Buckley C.T. and Kelly D.J. 2012
. Established Researcher Award: Bioengineering in Ireland18, Belfast 27-28 January, 2012. External mechanical stimulus can override the influence of local substrate in determining mesenchymal stem cell fate. Thorpe S.D., Buckley C.T., Steward A.J. and Kelly D.J. 2012
. Best overall oral poster presentation- Tissue Engineering and Regenerative Medicine International Society (TERMIS), Galway Ireland, 13th-17th June 2010. Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J.: Chondrogenesis of Mesenchymal Stem Cells is Regulated by Dynamic Compression Post TGF-â3 induced Differentiation. 2010
. SFI Short Term Travel Fellowship (STTF) 2009: Awarded €15,000 to acquire expertise and training in the isolation, purification and characterisation of mesenchymal stem cells (MSCs) from different tissue sources (bone marrow, intramedullary adipose tissue, infrapatellar fat pad and synovium membrane) using magnetic bead separation technology and FACS. International Laboratory Collaborators: Prof. Dennis McGonagle and Dr. Elena Jones, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom. 2009
  • Tissue Engineering of the Intervertebral Disc
  • Functional tissue engineering: Design and fabrication technology for scaffold based repair
  • Development of biomedical devices and solutions for innovative "in-theatre" clinical intervention
  • Rapid isolation of mesenchymal stem cell populations (MSCs) from various tissue sources utilizing magnetic bead enrichment and selection techniques for direct clinical use
  • Numerical modeling and characterization of microenvironments on tissue development by mesenchymal stem cells undergoing differentiation.
  • Development of bioreactor based systems to simulate in vivo biophysical and biochemical environments
  • Influence of biophysical stimuli on neocartilage tissue formation for the repair of osteochondral defects
  • Design and development of bioreactor based systems to simulate in vivo biophysical and biochemical environments
  • Regulation and influence of hypoxia environments of mesenchymal stem cells undergoing chondrogenesis
  • Development of biomedical devices to deliver cell seeded hydrogels/scaffolds
  • Design and fabrication of porous ceramic based scaffolds for use in tissue engineering investigations