Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Dr. Matthew Campbell

Assistant Professor (Genetics)
EAST END DEVELOPMENT 4/5


  AGE-RELATED MACULOPATHY   Alzheimer's Disease   BLOOD-BRAIN-BARRIER   Cell signalling, proliferation & differentiation   Cellular Biology   ENDOTHELIAL CELLS   Genetics   INFLAMMATION   Molecular Biology   Molecular Genetics   Neurobiology   neurodegeneration   Neuroscience   siRNA technology   TIGHT JUNCTIONS   Transgenics   Vision
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbroucke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Correction: Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017 [Fluids Barriers CNS 14, (2017) (31)] DOI: 10.1186/s12987-017-0079-9, Fluids and Barriers of the CNS, 15, (1), 2018, p3-, Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Campbell, M. and Cassidy, P.S. and O'Callaghan, J. and Crosbie, D.E. and Humphries, P., Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension, Progress in Retinal and Eye Research, 62, 2018, p120-133 , Notes: [cited By 0], Journal Article, PUBLISHED  TARA - Full Text  DOI
Theodoropoulou S, Copland D.A, Liu J, Wu J, Gardner P.J, Ozaki E, Doyle S.L, Campbell M, Dick A.D, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, Journal of Pathology, 241, (1), 2017, p45 - 56, Notes: [Export Date: 21 February 2017], Journal Article, PUBLISHED  DOI  URL
Shah T.M, Gupta S.M, Chatterjee P, Campbell M, Martins R.N, Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer†s disease, Molecular Psychiatry, 22, 2017, p353-363-, Journal Article, PUBLISHED  DOI  URL
Tam L.C.S, Reina-Torres E, Sherwood J.M, Cassidy P.S, Crosbie D.E, LÃ"tjen-Drecoll E, FlÃ"gel-Koch C, Perkumas K, Humphries M.M, Kiang A.-S, O'Callaghan J, Callanan J.J, Read A.T, Ethier C.R, O'Brien C, Lawrence M, Campbell M, Stamer W.D, Overby D.R, Humphries P, Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia, Scientific Reports, 7, 2017, p40717-, Notes: [Export Date: 20 February 2017], Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
O'Callaghan, J. and Crosbie, D.E. and Cassidy, P.S. and Sherwood, J.M. and FlÃŒgel-Koch, C. and LÃŒtjen-Drecoll, E. and Humphries, M.M. and Reina-Torres, E. and Wallace, D. and Kiang, A.-S. and Campbell, M. and Stamer, W.D. and Overby, D.R. and O'Brien, C. and Tam, L.C.S. and Humphries, P., Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, 26, (7), 2017, p1230-1246 , Notes: [cited By 6], Journal Article, PUBLISHED  DOI
Menard, C. and Pfau, M.L. and Hodes, G.E. and Kana, V. and Wang, V.X. and Bouchard, S. and Takahashi, A. and Flanigan, M.E. and Aleyasin, H. and Leclair, K.B. and Janssen, W.G. and Labonté, B. and Parise, E.M. and Lorsch, Z.S. and Golden, S.A. and Heshmati, M. and Tamminga, C. and Turecki, G. and Campbell, M. and Fayad, Z.A. and Tang, C.Y. and Merad, M. and Russo, S.J., Social stress induces neurovascular pathology promoting depression, Nature Neuroscience, 20, (12), 2017, p1752-1760 , Notes: [cited By 3], Journal Article, PUBLISHED  DOI
Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbrouke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017, Fluids and Barriers of the CNS, 14, (1), 2017, p31-, Notes: [cited By 1], Journal Article, PUBLISHED  TARA - Full Text  DOI
Delaney, C. and Campbell, M., The blood brain barrier: Insights from development and ageing, Tissue Barriers, 5, (4), 2017, pe1373897 -, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Greene C, Campbell M, Tight junction modulation of the blood brain barrier: CNS delivery of small molecules, Tissue Barriers, 4, (1), 2016, pe1138017-, Notes: [Cited By :2 Export Date: 21 February 2017], Journal Article, PUBLISHED  DOI  URL
  

Page 1 of 7

  

My laboratory focuses primarily on the molecular biology and physiology of the vasculature associated with neural tissues. We use genetic and molecular biology based approaches to explore the interplay between neural tissue and the systemic circulation. One major topic of my research is centered on the tight junctions located between microvascular endothelial cells of the blood brain and inner blood retina barriers (BBB/iBRB) and how these barriers function in health and disease. We aim to develop technologies to address an unmet clinical need for a range of neural conditions that currently have limited forms of therapeutic intervention and these include Alzheimer Disease, Multiple Sclerosis, Glioblastoma multiforme (GBM) and traumatic brain injury (TBI). In addition to translational interests, our lab is also heavily focused on elucidating the under-lying mechanisms of the diseases we are studying and this has led to novel findings associated with the molecular pathology of age-related macular degeneration (AMD). Identification of novel therapeutic targets has the potential to rapidly translate to new medicines and this is a strong focus of the lab at present.