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Dr. Adrian Bracken

Asst Prof in Medical Molecular Genetics (Genetics)

Dr. Adrian Bracken is an Assistant Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. The lab's most recent two papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 NSMB), and the role of the tumour suppressor, CHD5, during neurogenesis.on (Egan et al., Developmental Cell. 2013).
  Cancer Genetics   Epigenetics   Stem Cell Biology
 Epigenetic Regulation of Embryonic Stem Cell Differeniation
 Transcriptional Regulation of Cellular senescence

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Aloraifi F, Alshehhi M, McDevitt T, Cody N, Meany M., O'Doherty A, Quinn CM, Green AJ, Bracken A, Geraghty JG, Comparison of BRCAx tumors with BRCA1 - BRCA2-carriers and non-familial breast cancer. , EJSO, 41, (5), 2015, p641-646 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Gerard L. Brien, Andrei V. Krivtsov, Emilia Jerman, and Scott A. Armstrong, Adrian P. Bracken., Polycomb-like proteins define variant PRC2 complexes in stem and progenitor cells and regulate proliferation upstream of the p53 and p16 pathways. , Epigenetics and Cancer - Keystone Symposia, Keystone, CO, USA,, January 25-30, 2015, 2015, Oral Presentation, PUBLISHED
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GF, Helin K, Holmberg J, Bracken AP. , CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression., Developmental Cell., 26, (3), 2013, p223 - 236, Notes: [ Volume 26, Issue 3, 223-236], Journal Article, PUBLISHED  DOI
Turner, SA and Bracken AP. , A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145 - 146, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH., Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation. , The Journal of Experimental Medicine., 210, (6), 2013, p1117 - 1124, Journal Article, PUBLISHED  DOI
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP, Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation, Nature Structural & Molecular Biology, 19, (12), 2012, p1273-1281 , Notes: [Nov 18. doi: 10.1038/nsmb.2449. ], Journal Article, PUBLISHED  DOI  URL
Lanigan F, Geraghty JG, Bracken AP., Transcriptional regulation of cellular senescence, Oncogene, 30, 2011, p2901-2911 , Notes: [Pubmed ID: 21383691], Journal Article, PUBLISHED  DOI
Bracken AP, Helin K., Polycomb group proteins: navigators of lineage pathways led astray in cancer, Nature Reviews Cancer, 9, (11), 2009, p773 - 784, Notes: [Pubmed ID: 19851313], Journal Article, PUBLISHED  TARA - Full Text  DOI
Brien GL, Bracken AP., Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation, Seminars in Cell and Developmental Biology, 20, (7), 2009, p835 - 841, Notes: [Pubmed ID: 19682593], Journal Article, PUBLISHED  TARA - Full Text  DOI
Pasini, D., Bracken, A.P., Agger, K., Christensen, J., Hansen, K., Cloos, P.A.C., Helin, K. , Regulation of stem cell differentiation by histone methyltransferases and demethylases, Cold Spring Harbor Symposia on Quantitative Biology , 73, 2008, p253-263 , Notes: [ PubMed ID: 19022750], Journal Article, PUBLISHED  DOI

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Benitah SA, Bracken AP, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL., Stem cell epigenetics: looking forward, 14, 6, Cell Stem Cell, 2014, p606 - 709, Report, PUBLISHED


The group is led by Adrian Bracken and was established in 2008 at the Smurfit Institute of Genetics, Trinity College Dublin. We are studying the molecular mechanisms of stem cells and cancer. Our most recent two papers include a study on the role of Polycomb group proteins in embryonic stem cells, and the role of the tumour suppressor (Cancer brake gene), CHD5, during neurogenesis.