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Dr. Adrian Bracken

Assoc Prof in Medical Molecular Genetics (Genetics)

Dr. Adrian Bracken is an Associate Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. Three of the lab's papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 Nature Structural & Molecular Biology), the role of the tumour suppressor, CHD5, during neurogenesis (Egan et al., Developmental Cell. 2013) and the link between PCL1 and the p53 tumour suppressor in the regulation of cellular proliferation (Brien et al., Genes & Development, 2015). More recently, the lab has studied the Sin3a chromatin complex in mouse embryonic stem cells (Streubel et al., EMBO, 2017) and discovered a new family of vertebrate specific proteins that link nuclear receptor signalling and chromatin biology (Conway et al., Molecular Cell, 2018).
  Cancer Genetics   Cellular identity   Chromatin biology   Epigenetics   Gene expression control   Polycomb proteins   Stem Cell Biology   The EZH2 oncogene
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Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, and Bracken AP. , PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation, Molecular Cell, In Press, 2019, Journal Article, IN_PRESS
Deevy O and Bracken AP., PRC2 functions in development and congenital disorders, Development, In press., 2019, Journal Article, IN_PRESS
Bracken AP, Brien GL and Verrijzer CP., Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer. , Genes & Development, 33, 2019, p1 - 24, Journal Article, PUBLISHED
Brien GL, Bracken AP., The 3D Genome: EZH2 Comes into the Fold., Trends in Molecular Medicine, 25, (5), 2019, p362 - 365, Journal Article, PUBLISHED  DOI
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, Deevy O, Glancy E, Fitzpatrick DJ, Mucha M, Watson A, Rice AM, Chammas P, Huang C, Bracken AP., A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities., Molecular Cell, 70, (3), 2018, p408-421 , Journal Article, PUBLISHED  DOI
Streubel G, Watson A, Jammula SG, Scelfo A, Fitzpatrick DJ, Oliviero G, McCole R, Conway E, Glancy E, Negri GL, Dillon E, Wynne K, Pasini D, Krogan NJ, Bracken AP*, Cagney G*. (* Equal last authors)., The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells., Molecular Cell, 70, (2), 2018, p371-379 , Journal Article, PUBLISHED  DOI
Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes. in, editor(s)Vincenzo Pirrotta , Polycomb Group Proteins, 2017, pp57-80 , [Conway, EM., Bracken, AP.], Book Chapter, PUBLISHED  DOI
Streubel, G., Fitzpatrick, Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal, EMBO Journal, 36, 2017, p2216 - 2232, Journal Article, PUBLISHED  DOI
Erceg J, Pakozdi T, Marco-Ferreres R, Ghavi-Helm Y, Girardot C, Bracken AP, Furlong EE., Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements., Genes & Development, 31, (6), 2017, p590-602 , Journal Article, PUBLISHED  DOI
Oliviero, G., Brien, G.L., Waston, A., Streubel, G., Jerman, E., Andrews, D., Doyle, B., Munawar, N., Wynne, K., Crean, J., Bracken, A.P., Cagney, G., Dynamic protein interactions of the polycomb repressive complex 2 during differentiation of pluripotent cells., Molecular and Cellular Proteomics, 15, (11), 2016, p3450-3460 , Journal Article, PUBLISHED  DOI

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Award Date
Elected Fellow of Trinity College Dublin (FTCD) 2018-