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Dr. Adrian Bracken

Asst Prof in Medical Molecular Genetics (Genetics)

Dr. Adrian Bracken is an Assistant Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. Three of the lab's most significant recent papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 Nature Structural & Molecular Biology), the role of the tumour suppressor, CHD5, during neurogenesis (Egan et al., Developmental Cell. 2013) and the link between PCL1 and the p53 tumour suppressor in the regulation of cellular proliferation (Brien et al., Genes & Development, 2015).
  Cancer Genetics   Epigenetics   Stem Cell Biology
 Epigenetic Regulation of Embryonic Stem Cell Differeniation
 Transcriptional Regulation of Cellular senescence

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Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP, A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence., Genes & development, 29, (21), 2015, p2231-43 , Journal Article, PUBLISHED
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP., Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients., FEBS J, 282, (18), 2015, p3455 - 3473, Journal Article, PUBLISHED
Aloraifi F, Alshehhi M, McDevitt T, Cody N, Meany M., O'Doherty A, Quinn CM, Green AJ, Bracken A, Geraghty JG, Comparison of BRCAx tumors with BRCA1 - BRCA2-carriers and non-familial breast cancer. , EJSO, 41, (5), 2015, p641-646 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP., Detection of novel germline mutations for breast cancer in non-BRCA1/2 families., FEBS J., 282, (17), 2015, p3424 - 3437, Journal Article, PUBLISHED
Conway E, Healy E, Bracken AP, PRC2 mediated H3K27 methylations in cellular identity and cancer, Current Opinion in Cell Biology, 37, 2015, p42 - 48, Review Article, PUBLISHED
Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GF, Helin K, Holmberg J, Bracken AP. , CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression., Developmental Cell., 26, (3), 2013, p223 - 236, Notes: [ Volume 26, Issue 3, 223-236], Journal Article, PUBLISHED  DOI
Turner, SA and Bracken AP. , A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145 - 146, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH., Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation. , The Journal of Experimental Medicine., 210, (6), 2013, p1117 - 1124, Journal Article, PUBLISHED  DOI
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP, Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation, Nature Structural & Molecular Biology, 19, (12), 2012, p1273-1281 , Notes: [Nov 18. doi: 10.1038/nsmb.2449. ], Journal Article, PUBLISHED  DOI  URL
Lanigan F, Geraghty JG, Bracken AP., Transcriptional regulation of cellular senescence, Oncogene, 30, 2011, p2901-2911 , Notes: [Pubmed ID: 21383691], Journal Article, PUBLISHED  DOI

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Streubel G, Bracken AP., MED23: a new Mediator of H2B monoubiquitylation., EMBO J. 2015 Oct 5. pii: e201592996., 2015, Report, PUBLISHED
Benitah SA, Bracken AP, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL., Stem cell epigenetics: looking forward, 14, 6, Cell Stem Cell, 2014, p606 - 709, Report, PUBLISHED


The group is led by Adrian Bracken and was established in 2008 at the Smurfit Institute of Genetics, Trinity College Dublin. We study chromatin regulators and their molecular mechanisms of action in stem cells and cancer.