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Dr. Adrian Bracken

Asst Prof in Medical Molecular Genetics (Genetics)

Dr. Adrian Bracken is an Assistant Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. The lab's most recent two papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 NSMB), and the role of the tumour suppressor, CHD5, during neurogenesis.on (Egan et al., Developmental Cell. 2013).
  Cancer Genetics   Epigenetics   Stem Cell Biology
 Epigenetic Regulation of Embryonic Stem Cell Differeniation
 Transcriptional Regulation of Cellular senescence

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Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GF, Helin K, Holmberg J, Bracken AP. , CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression., Developmental Cell., 26, (3), 2013, p223 - 236, Notes: [ Volume 26, Issue 3, 223-236], Journal Article, PUBLISHED  DOI
Turner, SA and Bracken AP. , A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs., Cell Stem Cell, 12, (2), 2013, p145 - 146, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP, Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation, Nature Structural & Molecular Biology, 19, (12), 2012, Notes: [Nov 18. doi: 10.1038/nsmb.2449. ], Journal Article, PUBLISHED  URL
Lanigan F, Geraghty JG, Bracken AP., Transcriptional regulation of cellular senescence, Oncogene, 30, 2011, p2901-2911 , Notes: [Pubmed ID: 21383691], Journal Article, PUBLISHED  DOI
Bracken AP, Helin K., Polycomb group proteins: navigators of lineage pathways led astray in cancer, Nature Reviews Cancer, 9, (11), 2009, p773 - 784, Notes: [Pubmed ID: 19851313], Journal Article, PUBLISHED  TARA - Full Text  DOI
Brien GL, Bracken AP., Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation, Seminars in Cell and Developmental Biology, 20, (7), 2009, p835 - 841, Notes: [Pubmed ID: 19682593], Journal Article, PUBLISHED  DOI
Pasini, D., Bracken, A.P., Agger, K., Christensen, J., Hansen, K., Cloos, P.A.C., Helin, K. , Regulation of stem cell differentiation by histone methyltransferases and demethylases, Cold Spring Harbor Symposia on Quantitative Biology , 73, 2008, p253-263 , Notes: [ PubMed ID: 19022750], Journal Article, PUBLISHED  DOI
Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K., A model for transmission of the H3K27me3 epigenetic mark, Nature Cell Biology, 10, (11), 2008, p1291 - 1300, Notes: [PubMed ID: 18931660], Journal Article, PUBLISHED  URL
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA, H3K79 methylation profiles define murine and human MLL-AF4 leukemias., Cancer Cell, 14, (5), 2008, p355-368 , Notes: [PubMed ID: 18977325 ], Journal Article, PUBLISHED  DOI
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH and Helin K., The Polycomb Group Proteins Bind Throughout the INK4A-ARF locus and are Disassociated in Senescent Cells., Genes and Development, 21, (5), 2007, p525 - 530, Notes: [PubMed ID: 17344414 ], Journal Article, PUBLISHED  DOI

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The group is led by Adrian Bracken and was established in 2008 at the Smurfit Institute of Genetics, Trinity College Dublin. We are studying the molecular mechanisms of stem cells and cancer. Our most recent two papers include a study on the role of Polycomb group proteins in embryonic stem cells, and the role of the tumour suppressor (Cancer brake gene), CHD5, during neurogenesis.