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Dr. Adrian Bracken

Assoc Prof in Medical Molecular Genetics (Genetics)

Dr. Adrian Bracken is an Associate Professor at The Smurfit Institute of Genetics, Trinity College Dublin. During his post-doctorate years he gained an international reputation for using Cancer Epigenetics to explore cancer pathways and identify novel prognostic and therapeutic targets. He is a PhD graduate of Trinity College Dublin (2000) and has held fellowships at The European Institute of Oncology, Milan, Italy and The Biotechnology and Research Innovation Centre at The University of Copenhagen, Denmark. Currently he is consolidating his own independent research group. Three of the lab's most significant recent papers include a study on the role of Polycomb group proteins in embryonic stem cells (Brien et al., 2012 Nature Structural & Molecular Biology), the role of the tumour suppressor, CHD5, during neurogenesis (Egan et al., Developmental Cell. 2013) and the link between PCL1 and the p53 tumour suppressor in the regulation of cellular proliferation (Brien et al., Genes & Development, 2015).
  Cancer Genetics   Epigenetics   Stem Cell Biology
 Epigenetic Regulation of Embryonic Stem Cell Differeniation
 Transcriptional Regulation of Cellular senescence

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Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes in, Polycomb Group Proteins, 2017, pp57-80 , [Conway, E.M., Bracken, A.P.], Book Chapter, PUBLISHED
Streubel, G., Fitzpatrick, D.J., Oliviero, G., (...), Cagney, G., Bracken, A.P., Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal, EMBO Journal, 2017, Journal Article, IN_PRESS  DOI
Brien, G.L., Bracken, A.P., The PCL1-p53 axis promotes cellular quiescence, Cell Cycle, 15, (3), 2016, 305-306 , Journal Article, PUBLISHED  DOI
Oliviero, G., Brien, G.L., Waston, A., (...), Bracken, A.P., Cagney, G., Dynamic protein interactions of the polycomb repressive complex 2 during differentiation of pluripotent cells, Molecular and Cellular Proteomics, 15, (11), 2016, p3450-3460 , Notes: [ ], Journal Article, PUBLISHED  DOI
Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP, A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence., Genes & development, 29, (21), 2015, p2231-43 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP., Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients., FEBS J, 282, (18), 2015, p3455 - 3473, Journal Article, PUBLISHED
Aloraifi F, Alshehhi M, McDevitt T, Cody N, Meany M., O'Doherty A, Quinn CM, Green AJ, Bracken A, Geraghty JG, Comparison of BRCAx tumors with BRCA1 - BRCA2-carriers and non-familial breast cancer. , EJSO, 41, (5), 2015, p641-646 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Aloraifi F, McDevitt T, Martiniano R, McGreevy J, McLaughlin R, Egan CM, Cody N, Meany M, Kenny E, Green AJ, Bradley DG, Geraghty JG, Bracken AP., Detection of novel germline mutations for breast cancer in non-BRCA1/2 families., FEBS J., 282, (17), 2015, p3424 - 3437, Journal Article, PUBLISHED
Oliviero G, Munawar N, Watson A, Streubel G, Manning G, Bardwell V, Bracken AP, Cagney G, The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis., Scientific reports, 5, 2015, p18388 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Conway E, Healy E, Bracken AP, PRC2 mediated H3K27 methylations in cellular identity and cancer, Current Opinion in Cell Biology, 37, 2015, p42 - 48, Review Article, PUBLISHED

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Streubel G, Bracken AP., MED23: a new Mediator of H2B monoubiquitylation., EMBO J. 2015 Oct 5. pii: e201592996., 2015, Report, PUBLISHED
Benitah SA, Bracken AP, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL., Stem cell epigenetics: looking forward, 14, 6, Cell Stem Cell, 2014, p606 - 709, Report, PUBLISHED


The group is led by Adrian Bracken and was established in 2008 at the Smurfit Institute of Genetics, Trinity College Dublin. We study chromatin regulators and their molecular mechanisms of action in stem cells and cancer.