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Dr. Arun Bokde

Associate Professor (Psychiatry)
LLOYD INSTITUTE

Associate Professor (School Office - Medicine)

Associate Professor (Trinity Inst. of Neurosciences (TCIN))


Arun Bokde is Assistant Professor in Neuroimaging in the Discipline of Psychiatry, School of Medicine, at Trinity College Dublin. He leads the Cognitive Systems Group, is a principal investigator in the Trinity College Institute of Neuroscience (TCIN), and a member of the Global Brain Health Institute (GBHI). His initial appointment at Trinity College Dubiln was as SFI Stokes Lecturer in Biostatistical Imaging. Arun Bokde is member of two large European neuroimaging: the European DTI Study on Dementia (EDSD) and IMAGEN, a study of high-risk behaviors and mental disorders in adolescence. Before coming to Trinity College Dublin he was a Research Scientist at Ludwig Maximilian University in Munich, Germany; and previously he was a Postdoctoral Research Fellow at the National Institute on Aging and at the National Institute of Mental Health, both at the National Institutes of Health (USA). His first post-doctoral position was at Nothwestern University (USA). He obtained his PhD degree at the University of Texas at Austin. He has published widely on the risk factors that lead to the development of mental health disorders in young and older populations.
  Age related diseases   Ageing, memory and other cognitive processes   Ageing, stroke, dementia   Alzheimer's disease   Biostatistical methods   Development, prevention and treatment of mental disease or disorder   Human Learning and Memory   Imaging Techniques   Imaging, image processing   Neurodegeneration   Neurogenetics   Neuropharmacology   Neuropsychology   Psychiatry   Vision
 Effects of Brain Training in Older Healthy Subjects
 The application of magnetic resonance imaging to the study of memory processes in young and older healthy adults, and older adults with mild cognitive impairment.
 Neuronal Coordination
 Exist-Seed: Software development for measurement of the effects of cultural influences through functional magnetic resonance imaging
 Diagnosis of Alzheimer's disease using machine learning algorithms

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Details Date
Dementia and Neurodegeneration Network Ireland (DNNI) Multidisciplinary Consensus Panel since 2017
Reviewer for scientific journals and grant applications. since 2000
2015 Discover Science Night. 25-Sep-2015
2014 Discover Science Night. 26-Sep-2014
Co-Lead of Organizing Committee for workshop 'Neuroimaging in Dementia' May 2013
Co-Lead of Organizing Committee for workshop 'Application of neuroimaging in Alzheimer's disease' July 2013
Co-Lead of Organizing Committee for workshop 'Application of neuroimaging in Alzheimer's disease' September 2013
Co-Lead of Organizing Committee for workshop 'Introduction to theory and application of neuroimaging' September 2014
Co-Lead of Organizing Committee for workshop 'Neuroimaging - Theory and Practical Course' June 2015
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
German Medium Medium Medium
Spanish Fluent Medium Fluent
Details Date From Date To
Society of Neuroscience (USA) 1998
German Society for Neuroscience 2001
Organization of Human Brain Mapping 2002
Neuroscience Ireland 2014
Gonzalez DA, Jia T, Pinzón JH, Acevedo SF, Ojelade SA, Xu B, Tay N, Desrivières S, Hernandez JL, Banaschewski T, Büchel C, Bokde ALW, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Smolka MN; IMAGEN Consortium, Rodan AR, Schumann G, Rothenfluh A., The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans., Molecular psychiatry, 23, 2018, p621-628 , Journal Article, PUBLISHED  DOI
Nemmi, F. and Nymberg, C. and Darki, F. and Banaschewski, T. and Bokde, A.L.W. and BÃŒchel, C. and Flor, H. and Frouin, V. and Garavan, H. and Gowland, P. and Heinz, A. and Martinot, J.-L. and Nees, F. and Paus, T. and Smolka, M.N. and Robbins, T.W. and Schumann, G. and Klingberg, T., Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence, Developmental Cognitive Neuroscience, 30, 2018, p191-199 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Brislin, S.J. and Patrick, C.J. and Flor, H. and Nees, F. and Heinrich, A. and Drislane, L.E. and Yancey, J.R. and Banaschewski, T. and Bokde, A.L.W. and Bromberg, U. and BÃ"chel, C. and Quinlan, E.B. and DesriviÃ"res, S. and Frouin, V. and Garavan, H. and Gowland, P. and Heinz, A. and Ittermann, B. and Martinot, J.-L. and Martinot, M.-L.P. and Papadopoulos Orfanos, D. and Poustka, L. and Fröhner, J.H. and Smolka, M.N. and Walter, H. and Whelan, R. and Conrod, P. and Stringaris, A. and Struve, M. and van Noort, B. and Grimmer, Y. and Fadai, T. and Schumann, G. and Foell, J., Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project, Assessment, 2018, p1 - 15, Journal Article, PUBLISHED  DOI
Bossier, H. and Seurinck, R. and Simone Kühn, S. and Banaschewski, T. and Barker, G.J. and Bokde, A.L.W. and Martinot, J.-L. and Lemaitre, H. and Paus, T. and Millenet, S. and Moerkerke, B., The influence of study-level inference models and study set size on coordinate-based fMRI meta-analyses, Frontiers in Neuroscience, 11, (JAN), 2018, p00745-, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Cavedo E, Lista S, Rojkova K, Chiesa P.A, Houot M, Brueggen K, Blautzik J, Bokde A.L.W, Dubois B, Barkhof F, Pouwels P.J.W, Teipel S, Hampel H, Disrupted white matter structural networks in healthy older adult APOE ε4 carriers â€" An international multicenter DTI study, Neuroscience, 357, 2017, p119 - 133, Journal Article, PUBLISHED  DOI  URL
BÃ"chel C, Peters J, Banaschewski T, Bokde A.L.W, Bromberg U, Conrod P.J, Flor H, Papadopoulos D, Garavan H, Gowland P, Heinz A, Walter H, Ittermann B, Mann K, Martinot J.-L, PaillÃ"re-Martinot M.-L, Nees F, Paus T, Pausova Z, Poustka L, Rietschel M, Robbins T.W, Smolka M.N, Gallinat J, Schumann G, Knutson B, Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents, Nature Communications, 8, 2017, p14140-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Xu B, Jia T, Macare C, Banaschewski T, Bokde A.L.W, Bromberg U, BÃŒchel C, Cattrell A, Conrod P.J, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot J.-L, PaillÚre Martinot M.-L, Nees F, Orfanos D.P, Paus T, Poustka L, Smolka M.N, Walter H, Whelan R, Schumann G, DesriviÚres S, Banaschewski T, Barker G, Bokde A.L.W, Bromberg U, BÃŒchel C, Quinlan E.B, DesriviÚres S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot J.-L, PaillÚre Martinot M.-L, Artiges E, Lemaitre H, Nees F, Orfanos D.P, Paus T, Poustka L, Smolka M.N, Vetter N.C, Jurk S, Mennigen E, Walter H, Whelan R, Schumann G, Impact of a Common Genetic Variation Associated With Putamen Volume on Neural Mechanisms of Attention-Deficit/Hyperactivity Disorder, Journal of the American Academy of Child and Adolescent Psychiatry, 56, (5), 2017, p436 - 444.e4, Journal Article, PUBLISHED  DOI  URL
Khan W, Giampietro V, Banaschewski T, Barker G.J, Bokde A.L.W, BÃŒchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka M.N, Ströhle A, Gallinat J, Vellas B, Soininen H, Kloszewska I, Tsolaki M, Mecocci P, Spenger C, Villemagne V.L, Masters C.L, Muehlboeck J.-S, BÀckman L, Fratiglioni L, Kalpouzos G, Wahlund L.-O, Schumann G, Lovestone S, Williams S.C.R, Westman E, Simmons A, A Multi-Cohort Study of ApoE ϵ 4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease, Journal of Alzheimer's Disease, 56, (3), 2017, p1159 - 1174, Journal Article, PUBLISHED  DOI  URL
Quinlan E.B, Cattrell A, Jia T, Artiges E, Banaschewski T, Barker G, Bokde A.L.W, Bromberg U, BÃŒchel C, BrÃŒhl R, Conrod P.J, Desrivieres S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot J.-L, Martinot M.-L.P, Nees F, Papadopoulos-Orfanos D, Paus T, Poustka L, Smolka M.N, Vetter N.C, Walter H, Whelan R, Glennon J.C, Buitelaar J.K, Happé F, Loth E, Barker E.D, Schumann G, Psychosocial stress and brain function in adolescent psychopathology, American Journal of Psychiatry, 174, (8), 2017, p785 - 794, Journal Article, PUBLISHED  DOI  URL
Brueggen K, Grothe MJ, Dyrba M, Fellgiebel A, Fischer F, Filippi M, Agosta F, Nestor P, Meisenzahl E, Blautzik J, Frölich L, Hausner L, Bokde AL, Frisoni G, Pievani M, Klöppel S, Prvulovic D, Barkhof F, Pouwels PJ, Schröder J, Hampel H, Hauenstein K, Teipel S., The European DTI Study on Dementia - A multicenter DTI and MRI study on Alzheimer's disease and Mild Cognitive Impairment., Neuroimage, 144, 2017, p305 - 308, Journal Article, PUBLISHED  DOI
  

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Award Date
Sigma Gamma Tau, Member 1987
Arun Bokde investigates how large-scale brain networks function and how they are associated with both normal cognition, such as memory and attention, and breakdowns that lead to brain disorders. There are two populations of interest, young people and older people. Bokde uses functional magnetic resonance imaging to measure brain activation during visual perceptual tasks, as well as working memory tasks in persons with mild cognitive impairment, patients with Alzheimer's disease (AD), and healthy participants. These studies provide an understanding of how disease affects not only memory networks, but also perceptual processes in the brain. Recent findings were the basis of a new approach to testing AD-related drugs. In addition, Bokde has investigated the structural integrity of brain networks using diffusion imaging in combination with tractography in the limbic system, a network associated with memory function and profoundly affected in patients with AD. Bokde has also led an international project to develop training resources for the application of neuroimaging to the diagnostic process of AD patients, as well as developing resources for patients and their families to gain a better understanding of the disease. Bokde is co-PI (Ireland) for the the IMAGEN study, which is the first multicentre functional and structural genetic-neuroimaging study of a cohort of 2000 +14 year old adolescents. Cognitive, behavioural, clinical and neuroimaging data from the adolescents and their families and teachers have been gathered and the participants have been followed-up for 9 years - the third follow-up investigation is on-going. Bokde is investigating how stress modulates the development of brain networks, both within the thin cortical grey matter layer and the white matter regions that contain the 'cables' of the brain networks. The studies have been until now cross-sectional in nature and with new longitudinal data Bokde will start investigation of the interaction among stress, biological and genetic factors contributing to mental health disorders. He has close, long-standing collaborations with clinicians at St James's Hospital, Tallaght Hospital, and St Patrick's University Hospital. The collaborations enhance the communication and translation of research into the clinical context as well as feedback into research activities.