Skip to main content

Trinity College Dublin, The University of Dublin

Menu Search


Trinity College Dublin By using this website you consent to the use of cookies in accordance with the Trinity cookie policy. For more information on cookies see our cookie policy.

      
Profile Photo

Professor Andrew Bowie

Professor of Innate Immunology (Biochemistry)


Andrew Bowie obtained his PhD in Biochemistry from Trinity College Dublin in 1997. After postdoctoral training with Prof Luke O'Neill, he was appointed as lecturer in the Department of Pharmacology in UCD, before returning to TCD in 2001 to establish the first and only Immunology undergraduate degree course in Ireland, which he coordinated from 2002 - 2006. He served as Director of Research in the School of Biochemistry and Immunology from 2005 - 2009, and as Head of Immunology from 2011 - 2017. In 2008 he was elected a Fellow of TCD, and in 2014 a member of the Royal Irish Academy. He is actively involved in both undergraduate and postgraduate Immunology teaching, and has graduated 14 PhD students to date. His research discoveries and scholarly activities have significantly contributed to TCD's global reputation as a place of excellence for Immunology teaching and research and in 2017 he was awarded the Irish Society for Immunology Public Lecture Medal for his outstanding contribution to Irish Immunology. He is a global leader in the research fields of innate immunity and viral evasion, and his research occupies a unique space at the interface between virology, immunology and disease pathogenesis. He has raised research funding of >€9m (direct costs to PI) since 2001, from national and international funding agencies including Science Foundation Ireland, the EU and the US National Institutes of Health, and also from private industry. Work in his laboratory has shed light on how pattern recognition receptors (PRRs) recognise pathogens, leading to the induction of interferons and cytokines, which control infection locally as well as coordinating the adaptive immune response. He also investigates how PRRs and other innate immune sensors drive inflammation, and discovered one of the key cellular sensors of DNA in 2010, IFI16, which has subsequently been shown to be critical in understanding viral pathogenesis of diverse viruses including HIV and herpes viruses. He has recently identified novel roles for a number of innate immune proteins in regulating inflammation via cytokine modulation, and is currently exploring their mechanisms of action. His seminal discoveries have redefined our understanding of how pathogens engage with human cells, and he has regularly published research papers, opinion pieces and reviews in leading international journals including Nature Immunology, Immunity, The Journal of Experimental Medicine, Nature Reviews Immunology, PNAS, PLoS Pathogens and The EMBO Journal.
  Biochemistry   Cellular Biology   CYTOKINES   DNA SENSING   DNA transcription and translation   Eukaryotic gene regulation   Host, Pathogen interactions   Immune system   Immunology, Immunotherapy   Infectious diseases   Inflammation   Innate Immunity   INTERLEUKIN-1 SIGNAL TRANSDUCTION   Intra and intercellular signalling   Molecular Biology   NF-kappaB   PATTERN RECOGNITION RECEPTORS   Protein sequence, function and expression   Regulatory methods of gene expression   Signal Transduction   Toll-Like Receptors   Viral Evasion   Virology and viral pathogenesis   VIRUSES
Details Date From Date To
Royal Irish Academy 15 March 2014
The International Cytokine and Interferon Society
American Society for Biochemistry and Molecular Biology
American Society for Microbiology
Carty M, Bowie AG., SARM: from immune regulator to cell executioner., Biochemical pharmacology, 2019, Journal Article, PUBLISHED  DOI
Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃŒrtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Bowie, A.G., Harnessing poxviral know-how for anti-cytokine therapies, Journal of Biological Chemistry, 294, (13), 2019, p5228-5229 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Bowie, A.G., Self-RNA sentinels signal viral invasion news-and-views, Nature Immunology, 19, (1), 2018, p4-5 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM, 2018, p217-224 , Journal Article, PUBLISHED  URL
Dempsey A, Keating SE, Carty M, Bowie AG., Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses., The Journal of biological chemistry, 293, (39), 2018, p14989-15001 , Journal Article, PUBLISHED  DOI
Dunphy G, Flannery SM, Almine JF, Connolly DJ, Paulus C, Jønsson KL, Jakobsen MR, Nevels MM, Bowie AG, Unterholzner L., Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-"B Signaling after Nuclear DNA Damage., Molecular cell, 71, (5), 2018, p745-760.e5 , Journal Article, PUBLISHED  DOI
Almine J., Almine J., O'Hare C., O'Hare C., Dunphy G., Dunphy G., Haga I., Naik R., Atrih A., Connolly D., Taylor J., Kelsall I., Bowie A., Beard P., Beard P., Unterholzner L., Unterholzner L., IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes, Nature Communications, 8, 2017, p14392 , Journal Article, PUBLISHED  TARA - Full Text  DOI
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764, Journal Article, PUBLISHED  TARA - Full Text  DOI
Brady, G., Haas, D.A., Farrell, P.F., Pichlmair, A. and Bowie, A.G. , Molluscum Contagiosum Virus protein MC005 inhibits NFκB activation by targeting NEMO-regulated IKK activation, The Journal of Virology, 91, (15), 2017, p00545-17 , Notes: [doi:10.1128/JVI.00545-17], Journal Article, PUBLISHED  TARA - Full Text  DOI
  

Page 1 of 12
Bowie, A.G., Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2, Biochemistry Society Transactions, 36, (3), 2008, pp449-452 , Notes: [PMID: 18481979], Conference Paper, PUBLISHED
M. Schröder and A. G. Bowie, An arms race: Innate anti-viral responses and counter-acting viral strategies., Biochemistry Society Transactions, Biochemistry Society Transactions, 35, (6), 2007, pp1512-1514 , Notes: [PMID: 18031256], Conference Paper, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125S , Notes: [PMID: 9057023], Conference Paper, PUBLISHED
Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S. , Notes: [PMID: 9057029], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2S , Notes: [PMID: 8674662], Conference Paper, PUBLISHED
A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109S , Notes: [PMID: 7758669], Conference Paper, PUBLISHED
Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390S , Notes: [PMID: 8131967], Conference Paper, PUBLISHED

  

Award Date
Highly cited researcher (Clarivate, top 1% by citations) 2018
Irish Society for Immunology Public Lecture Award Medal 2017
Elected to the Royal Irish Academy 2014
Elected Fellow of TCD 2008
Sheldon Wolff Prize in Cytokine Research 1999
Placed first in class (B.A. (Mod)). 1993
My research focuses on innate immune sensing and signalling mechanisms, and their modulation by viruses. Specifically we are looking at how viruses interact with, and seek to subvert innate immune signalling pathways, such Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs). TLRs and RLRs represent host immune detection systems, in that they have been shown to be involved in recognising pathogens and activating the innate immune response. Through both bioinformatics and functional screens we have identified many poxviral proteins which can antagonise innate immune signalling, and current on-going investigations are seeking to understand the mechanism of action of these proteins and to identify and characterise host target proteins. Further, peptides derived from inhibitory viral proteins are being tested as a route to developing novel anti-inflammatory drugs. Work in my laboratory has shed light on how pattern recognition receptors (PRRs) recognise pathogens, leading to the induction of interferons and cytokines, which control infection locally as well as coordinating the adaptive immune response. We also investigate how PRRs and other innate immune sensors drive inflammation through the recognition of nucleic acid such as mislocalised self-DNA. I have recently identified novel roles for a number of innate immune proteins in regulating inflammation via cytokine modulation, and am currently exploring their mechanisms of action