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Professor Anne-Marie Healy

Professor (Pharmacy)
25/6/7 WESTLAND ROW

Co-ordinator MSc course Pharm.Technology (School Office - Pharmacy & Pharmceut Sci)


  Amorphous Materials   Computer modelling of pharmaceutical systems   Materials Sciences   Mechanisms of dissolution   Mechanisms of drug release from solid dosage forms   Pharmaceutical co-crystals   Pharmaceutical dissolution testing   Pharmaceutical processing   Pharmaceutical Sciences   pulmonary drug delivery   SPRAY DRYING
Details Date
Adjunct Experiential Instructor, St Louis College of Pharmacy 2016-date
Grant Reviewer for The Netherlands Organisation for Scientific Research (NWO) 2018
Treasurer of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2018
Member of the Board of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2017-date
Hospital Professional Awards judging panel member 2017
External Examiner to Griffith College Dublin: MSc in Pharmaceutical Business and Technology 2016-date
Grant reviewer for the Austrian Science Fund (FWF) 2016
Expert consultant/witness for US based pharmaceutical company in patent related litigation case 2016
Expert consultant/witness for Irish based pharmaceutical company in patent related litigation case 2016
Irish Pharmacy Awards judging panel member 2016
External Examiner to University of Bradford: MSc in Pharmaceutical Technology 2015-date
Grant reviewer for the Engineering and Physical Sciences Research Council (EPSRC), UK 2015
Judge for the national secondary school competition: Debating Science Issues (DSI) 2015
Member of the Implementation Steering Group for the Five-Year Integrated Pharmacy Programme 2014-date
Invited Medical and Scientific Advisory Board Member, Solvotrin Therapeutics Ltd. 2014-date
Co-ordinator of the EU-funded Erasmus Lifelong Learning Programme Project: Linking Industry and Academia in Pharmaceutical Development and Manufacture (LIAT-Ph) 2013-2015
Member of the National Pharmacy Forum 2013-2014
Member of the Editorial Advisory Board of Molecular Pharmaceutics 2013-date
Invited Scientific Advisory Board Member, Alkermes Ltd. 2013-2016
Co-PI, Strand Leader and Member of Management Committee of the Synthesis and Solid State Pharmaceutical Centre 2013-date
Member of the Accreditation Panel for the PSI Statutory Visit to the level 8 BPharm Degree Course at University College Cork 2013
Member of interview panel for General Manager of Synthesis and Solid State Pharmaceutical Centre, UL 2013
Member of interview panel for Chief Pharmacist position, Department of Health 2013
Grant reviewer for Fundação para a Ciência e a Tecnologia, I.P. (FCT) - Portuguese public funding agency for R&D 2012-2016
External Examiner to Hibernia College: MSc in Pharmaceutical Medicine 2012-date
External Examiner to Dublin Institute of Technology, School of Food Science and Environmental Health: Higher Certificate in Pharmacy Technician Studies 2012-2015
Member of the Curriculum Development Sub-forum of the National Pharmacy Forum 2011-2013
External Examiner for the Pharmaceutical Society of Ireland to the Professional Registration Examination 2011-2013
External Examiner to Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences: MSc in Pharmaceutical Quality Assurance & Regulation; MSc in Pharmaceutical Quality Assurance & Biotechnology 2009-2012
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2010
External Examiner to Carlow Institute of Technology, Department of Science and Health: Higher Certificate in Science - Pharmacy Technician Studies 2009-2012
Member of the Pharmaceutical Society of Ireland's Steering Group for the Pharmacy Education and Accreditation Reviews (PEARs) project 2008-2010
Co-PI, Strand Leader and Member of Management Committee of the Solid State Pharmaceutical Cluster 2007-2013
Member of the Validation Panel for the BSc (Ordinary) Validation of Medicinal Products at Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences 2006
Member of the Editorial Advisory Board of Pharmaceutical Technology Europe 2005-date
Enterprise Ireland Grant Reviewer 2005-2007
External examiner for PhD candidates in: Queen's University Belfast School of Pharmacy (x4), University of Nottingham School of Pharmacy (x1), University of Bradford School of Pharmacy (x1), the Royal College of Surgeons in Ireland School of Pharmacy (x1), University College Dublin School of Chemical and Bioprocess Engineering (x2), The Islamia University of Bahawalpur-Pakistan school of Pharmacy (x1) 2005-date
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2004
Honorary Treasurer and Chairperson (elected) of the Finance Committee of the Pharmaceutical Society of Ireland 2003-2006
Member of the Accreditation Committee of the Pharmaceutical Society of Ireland established to review new School of Pharmacy courses in RCSI and UCC 2000-2004
Consultant to a number of pharmaceutical companies 2000-date
Member of the Strategy Group of the Pharmaceutical Society of Ireland 2000
Member of the Board of Directors/Board of Management of Kenlis Publications Ltd., publisher of the Irish Pharmacy Journal 1999-2007
Member of the Schools Committee of the Pharmaceutical Society of Ireland 1997-2006
Member (elected) of the Council of the Pharmaceutical Society of Ireland 1997-2006
Regular reviewer for scientific journals (16) in the areas of Pharmaceutical Sciences 1995-date
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Irish Medium Basic Basic
Spanish Medium Basic Basic
Details Date From Date To
Member of Pharmacists in Industry, Education and Regulatory (PIER) 2013 date
Member of the Academy of Pharmaceutical Scientists (UK) 2005 date
Member of AAPS (American Association of Pharmaceutical Scientists) 2000 date
Member of the Pharmaceutical Society of Ireland 1990 date
Kumar D, Worku ZA, Gao Y, Kamaraju VK, Glennon B, Babu RP, Healy AM, Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties, Powder Technology, 330, 2018, p228-238 , Journal Article, PUBLISHED  DOI
Serrano DR, Walsh D, O'Connell P, Mugheirbi NA, Work, ZA, Bolas-Fernandez F, Galiana C, Dea-Ayuela MA, Healy AM, Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating, European Journal of Pharmaceutics and Biopharmaceutics, 124, 2018, p13-27 , Journal Article, PUBLISHED  DOI
Lamy B, Tewes F, Serrano DR, Lamarche I, Gobin P, Couet W, Healy AM, Marchand S, New aerosol formulation to control ciprofloxacin pulmonary concentration, Journal of Controlled Release, 271, 2018, p118-126 , Journal Article, PUBLISHED  DOI
Walsh D, Serrano DR, Worku ZA, Norris BA, Healy AM, Production of cocrystals in an excipient matrix by spray drying, International Journal of Pharmaceutics, 536, (1), 2018, p467-477 , Journal Article, PUBLISHED  DOI
Wang J, Radics G, Whelehan M, OÊ"Driscoll A, Healy AM, Gilmer JF, Ledwidge M, Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults, Acta Haematologica, 2018, p223-232 , Journal Article, PUBLISHED  DOI
Kavanagh ON, Albadarin AB, Croker DM, Healy AM, Walker GM., Maximising success in multidrug formulation development: A review., Journal of controlled release : official journal of the Controlled Release Society, 283, 2018, p1-19 , Journal Article, PUBLISHED  DOI
Kelleher JF, Gilvary GC, Madi AM, Jones DS, Li S, Tian Y, Almajaan A, Senta-Loys Z, Andrews GP, Healy AM., A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products., International journal of pharmaceutics, 545, (1-2), 2018, p183-196 , Journal Article, PUBLISHED  DOI
do Amaral, L.H., do Carmo, F.A., Amaro, M.I., de Sousa, V.P., da Silva, L.C.R.P., de Almeida, G.S., Rodrigues, C.R., Healy, A.M., Cabral, L.M., Development and characterization of dapsone cocrystal prepared by scalable production methods, AAPS PharmSciTech , 19, (6), 2018, p2687 - 2699, Journal Article, PUBLISHED  DOI
Rolón M, Serrano DR, Lalatsa A, de Pablo E, Torrado JJ, Ballesteros MP, Healy AM, Vega, C, Corone C, Bolás-Fernández F, Dea-Ayuela MA, Engineering oral and parenteral amorphous amphotericin B formulations against experimental Trypanosoma cruzi infections, Molecular Pharmaceutics, 14, (4), 2017, p1095-1106 , Journal Article, PUBLISHED  DOI
Simon A, Amaro MI, Healy AM, Cabral LM, de Sousa VP, Development of a discriminative in vitro release test for rivastigmine transdermal patches using pharmacopeial apparatuses: USP 5 and USP 6, AAPS PharmSciTech, 18 , (7), 2017, 2561-2569 , Journal Article, PUBLISHED  DOI
  

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F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046 , Meeting Abstract, PUBLISHED
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010, Poster, PUBLISHED
Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009, Meeting Abstract, PRESENTED
Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009, Poster, PRESENTED
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008, Meeting Abstract, PRESENTED
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract) , Conference Paper, PUBLISHED

  

Award Date
Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) 2014
Fellowship of Trinity College Dublin 2010
Mendell Award for Scientific Excellence (at the 13th International Conference on Pharmaceutical Technology, Strasbourg, France) 1994
Pharmaceutical Society of Ireland Gold Medal 1989
Jim Hegarty Memorial Prize in Pharmaceutical Chemistry 1989
University of Dublin, Trinity College Non-Foundation Scholarship 1987
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2016
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015
Pharma Industry Awards, Research & Development Achievement Award - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015
Pharma Industry Awards, Partnership Alliance of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2014
My research programme is focused on obtaining an increased understanding of the physicochemical properties of active and excipient materials used in a variety of different dosage forms, and on using that knowledge to improve product design in terms of in vitro and subsequently in vivo performance. This research objective is achieved through collaborative efforts and interdisciplinary research with both academic and industry partners, nationally and abroad. My research field is aligned with "Therapeutics: Synthesis, Formulation, Processing and Drug Delivery" which is one of 14 priority areas for research identified under the National Research Prioritisation Exercise (NRPE). My current research spans three principal strands: (i) Pharmaceutical material science (ii) Particle engineering for pulmonary drug delivery, and (iii) Enabling formulations for poorly soluble and poorly bioavailable therapeutic agents (i) Pharmaceutical material science Research under this theme is aimed at understanding how solid state and micromeritic characteristics of drug and excipient materials are impacted by pharmaceutical processing, and how formulation and/or processing may be optimized so as to control physicochemical characteristics and drug product performance for oral solid dosage forms. My expertise in this area has led to me taking on the role of Co-PI and Strand Leader in the Synthesis and Solid State Pharmaceutical Centre (SSPC), an SFI-industry co-funded research centre. (ii) Particle engineering for pulmonary drug delivery Sophisticated particle engineering processes enable improved delivery of powders via oral inhalation. In my group, we have developed an internationally recognised expertise in formulation and particle engineering by spray drying for dry powder inhalation. This expertise led to me being invited to join an international collaborative translational NIH-funded €8 million project, led by the University of California San Francisco, aimed at developing a novel mucolytic therapy for the treatment of lung disease, including cystic fibrosis and asthma. The project commenced in 2016. (iii) Enabling formulations for poorly soluble and poorly bioavailable therapeutic agents It is estimated that more than 60% of new drug molecules display poor aqueous solubility, due to an increased size and lipophilicity. There is a need for enabling formulations for such therapeutic agents which have suboptimal bioavailability. Alterations of the solid state form by means of salification, cocrystallization or amorphisation are options which we have explored, as is microencapsulation for controlled release. My group's expertise in this area forms the basis for a number of projects in the SSPC and in AMBER (Advanced Materials and BioEngineering Research centre), another SFI-industry funded research centre, where I am a funded investigator.