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Professor Anne-Marie Healy

Professor (Pharmacy)
25/6/7 WESTLAND ROW
      
Profile Photo

Professor Anne-Marie Healy

Professor (Pharmacy)
25/6/7 WESTLAND ROW

 healyam@tcd.ie

 3531896 1444


  Amorphous Materials   Computer modelling of pharmaceutical systems   Materials Sciences   Mechanisms of dissolution   Mechanisms of drug release from solid dosage forms   Pharmaceutical co-crystals   Pharmaceutical dissolution testing   Pharmaceutical processing   Pharmaceutical Sciences   pulmonary drug delivery   SPRAY DRYING
Project Title
 Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs)
From
01/10/2018
To
30/09/2022
Summary
In this project we will study the impact of drying conditions on the crystal form of the API and develop possible strategies to ensure the form is correctly managed during small scale and then large-scale drying operations.
Funding Agency
Irish Research Council/APC Ltd.
Programme
Irish Research Council Employment-Based Postgraduate Programme
Project Type
Applied
Person Months
48
Project Title
 The Development of Novel, Age-appropriate Oral Liquid Formulations to Meet Unmet Needs of Paediatric Patients
From
01/01/2017
To
31/12/2020
Summary
The goal of this project is to develop age-appropriate liquid formulations of two active pharmaceutical ingredients, which will address unmet patient needs.
Funding Agency
Irish Research Council/Xeolas Ltd.
Programme
Irish Research Council Enterprise Partnership Postgraduate Scholarship Programme
Project Type
Applied
Person Months
48
Project Title
 Mechanism of Mucus Pathology in Asthma Exacerbations
From
01/04/2016
To
31/03/2021
Summary
This project aims to advance understanding of mucus pathology in acute severe asthma and to hasten a new drug development program for thiol-saccharides as a novel mucolytic treatment for mucus pathology in acute asthma.
Funding Agency
National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
Programme
RO1
Project Type
Translational
Person Months
48
Project Title
 Carbohydrate-based Therapy for Lung Disease
From
01/07/2016
To
30/06/2021
Summary
The goal of this project is to translate our discovery of an unsuspected mechanism of mucus pathology into a mucolytic drug strategy that could benefit millions of patients with mucus-associated lung disease.
Funding Agency
National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
Programme
Translational Program Project Grant (tPPG)
Project Type
Translational
Person Months
60
Project Title
 Development of Fixed Dose Combination Products using Advanced Pharmaceutical Processing Technologies
From
01/09/2015
To
31/08/2019
Summary
The goal of this project is to develop novel fixed dose combination products using continuous pharmaceutical processes, thus addressing the issue of poor patient compliance, which is frequently associated with the long term and multiple dosage regimes, typical of CVD or diabetes.
Funding Agency
Science Foundation Ireland / Department for the Economy (Northern Ireland)
Programme
SFI Investigator's Programme
Project Type
Applied
Person Months
72

Page 1 of 2
Details Date
Grant reviewer for the Biotechnology and Biological Sciences Research Council (BBSRC), UK 2018
Grant Reviewer for The Netherlands Organisation for Scientific Research (NWO) 2018
Treasurer of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2018
Member of the Board of the Irish Platform for Patient Organisations, Science & Industry (IPPOSI) 2017-date
Committee member and Mentor for WiSSPC (Women in the Synthesis and Solid State Pharmaceutical Centre) 2017-date
Hospital Professional Awards judging panel member 2017
Adjunct Experiential Instructor, St Louis College of Pharmacy 2016-date
External Examiner to Griffith College Dublin: MSc in Pharmaceutical Business and Technology 2016-date
Grant reviewer for the Austrian Science Fund (FWF) 2016
Expert consultant/witness for US based pharmaceutical company in patent related litigation case 2016
Expert consultant/witness for Irish based pharmaceutical company in patent related litigation case 2016
Irish Pharmacy Awards judging panel member 2016
External Examiner to University of Bradford: MSc in Pharmaceutical Technology 2015-2018
Grant reviewer for the Engineering and Physical Sciences Research Council (EPSRC), UK 2015
Judge for the national secondary school competition: Debating Science Issues (DSI) 2015
Member of the Implementation Steering Group for the Five-Year Integrated Pharmacy Programme 2014-2015
Invited Medical and Scientific Advisory Board Member, Solvotrin Therapeutics Ltd. 2014-date
Co-ordinator of the EU-funded Erasmus Lifelong Learning Programme Project: Linking Industry and Academia in Pharmaceutical Development and Manufacture (LIAT-Ph) 2013-2015
Member of the National Pharmacy Forum 2013-2014
Member of the Editorial Advisory Board of Molecular Pharmaceutics 2013-date
Invited Scientific Advisory Board Member, Alkermes Ltd. 2013-2016
Co-PI, Strand Leader and Member of Management Committee of the Synthesis and Solid State Pharmaceutical Centre 2013-date
Member of the Accreditation Panel for the PSI Statutory Visit to the level 8 BPharm Degree Course at University College Cork 2013
Member of interview panel for General Manager of Synthesis and Solid State Pharmaceutical Centre, UL 2013
Member of interview panel for Chief Pharmacist position, Department of Health 2013
Grant reviewer for Fundação para a Ciência e a Tecnologia, I.P. (FCT) - Portuguese public funding agency for R&D 2012-2016
External Examiner to Hibernia College: MSc in Pharmaceutical Medicine 2012-date
External Examiner to Dublin Institute of Technology, School of Food Science and Environmental Health: Higher Certificate in Pharmacy Technician Studies 2012-2015
Member of the Curriculum Development Sub-forum of the National Pharmacy Forum 2011-2013
External Examiner for the Pharmaceutical Society of Ireland to the Professional Registration Examination 2011-2013
External Examiner to Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences: MSc in Pharmaceutical Quality Assurance & Regulation; MSc in Pharmaceutical Quality Assurance & Biotechnology 2009-2012
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2010
External Examiner to Carlow Institute of Technology, Department of Science and Health: Higher Certificate in Science - Pharmacy Technician Studies 2009-2012
Member of the Pharmaceutical Society of Ireland's Steering Group for the Pharmacy Education and Accreditation Reviews (PEARs) project 2008-2010
Co-PI, Strand Leader and Member of Management Committee of the Solid State Pharmaceutical Cluster 2007-2013
Member of the Validation Panel for the BSc (Ordinary) Validation of Medicinal Products at Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences 2006
Member of the Editorial Advisory Board of Pharmaceutical Technology Europe 2005-date
Enterprise Ireland Grant Reviewer 2005-2007
External examiner for PhD candidates in: University College London (x1), University of Helsonki (x1), Queen's University Belfast School of Pharmacy (x5), University of Nottingham School of Pharmacy (x1), University of Bradford School of Pharmacy (x1), the Royal College of Surgeons in Ireland School of Pharmacy (x1), University College Dublin School of Chemical and Bioprocess Engineering (x2), The Islamia University of Bahawalpur-Pakistan school of Pharmacy (x2) 2005-date
Member of assessment/interview panel to fill lecturing post in the Department of Chemical and Bioprocess Engineering in UCD 2004
Honorary Treasurer and Chairperson (elected) of the Finance Committee of the Pharmaceutical Society of Ireland 2003-2006
Consultant to a number of pharmaceutical companies 2000-date
Member of the Accreditation Committee of the Pharmaceutical Society of Ireland established to review new School of Pharmacy courses in RCSI and UCC 2000-2004
Member of the Strategy Group of the Pharmaceutical Society of Ireland 2000
Member of the Board of Directors/Board of Management of Kenlis Publications Ltd., publisher of the Irish Pharmacy Journal 1999-2007
Member of the Schools Committee of the Pharmaceutical Society of Ireland 1997-2006
Member (elected) of the Council of the Pharmaceutical Society of Ireland 1997-2006
Regular reviewer for scientific journals (16) in the areas of Pharmaceutical Sciences 1995-date
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Basic
Irish Medium Basic Basic
Spanish Medium Basic Basic
Details Date From Date To
Member of Pharmacists in Industry, Education and Regulatory (PIER) 2013 date
Member of the Academy of Pharmaceutical Scientists (UK) 2005 date
Member of AAPS (American Association of Pharmaceutical Scientists) 2000 date
Member of the Pharmaceutical Society of Ireland 1990 date
Autzen Virtanen, A. and Myslinska, M. and Healy, A.M. and Power, E. and Madi, A. and Siven, M., The challenge of downstream processing of spray dried amorphous solid dispersions into minitablets designed for the paediatric population - A sustainable product development approach, European Journal of Pharmaceutical Sciences, 196, (106752), 2024, Notes: [cited By 1], Journal Article, PUBLISHED  DOI
Andrews, G.P. and Healy, A.M. and Topp, E.M., Introducing the Molecular Pharmaceutics Special Issue on "Advances in Small and Large Molecule Pharmaceutics Research across Ireland", Molecular Pharmaceutics, 21, (8), 2024, p3693-3694 , Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Piatek, M. and Grassiri, B. and O'Ferrall, L.M. and Piras, A.M. and Batoni, G. and Esin, S. and O'Connor, C. and Griffith, D. and Healy, A.M. and Kavanagh, K., Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function, Journal of Biological Inorganic Chemistry, 29, 2024, p707 - 717, Notes: [cited By 0], Journal Article, PUBLISHED  DOI
Grassiri B, Esin S, Piatek ME, More O'Ferrall L, Sake JA, Griffith DM, Kavanagh K, Ehrhardt C, Maria Piras A, Batoni G, Marie Healy A, The activity of a Ga(III) catecholate complex against Aspergillus fumigatus in conditions mimicking cystic fibrosis lung and inhaled formulations for its pulmonary administration., International Journal of Pharmaceutics, 667, (A), 2024, p124871 , Journal Article, PUBLISHED  DOI
Simon A., Velloso-Junior S.O., Mesquita R.D., Fontao A.P.G.A., Costa T.E.M.M., Honorio T.S., Guimaraes T.F., Sousa E.G.R., Vicosa A.L., Sampaio A.L.F., do Carmo F.A., Healy A.M., Cabral L.M., Castro R.R., Development of inhaled moxifloxacin-metformin formulation as an alternative for pulmonary tuberculosis treatment, International Journal of Pharmaceutics, 666, 2024, p124740 , Journal Article, PUBLISHED  DOI
Taseva AR, Persoons T, Healy AM, D'Arcy DM., Application of shadowgraph imaging (SGI) particle characterisation data to interpret the impact of varying test conditions on powder dissolution and to develop an automated agglomeration identification method (AIM) in the USP flow-through apparatus., International journal of pharmaceutics, 666, 2024, p124778 , Journal Article, PUBLISHED  DOI
Tsolaki E., Healy A.M., Ferguson S., Development of polymer-encapsulated microparticles of a lipophilic API-IL and its lipid based formulations for enhanced solubilisation, International Journal of Pharmaceutics, 667, 2024, p124878 , Journal Article, PUBLISHED  DOI
Fernández-García R, Walsh D, O'Connell P, Slowing K, Raposo R, Paloma Ballesteros M, Jiménez-Cebrián A, Chamorro-Sancho MJ, Bolás-Fernández F, Healy AM, Serrano DR., Can amphotericin B and itraconazole be co-delivered orally? Tailoring oral fixed-dose combination coated granules for systemic mycoses., European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 183, 2023, p74-91 , Journal Article, PUBLISHED  DOI
Stocker MW, Tsolaki E, Harding MJ, Healy AM, Ferguson S., Combining Isolation-Free and Co-processing Manufacturing Approaches to Access Room Temperature Ionic Liquid Forms of APIs., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00052-7 , Journal Article, PUBLISHED  DOI
Myslinska M, Stocker MW, Ferguson S, Healy AM., A Comparison of Spray-Drying and Co-Precipitation for the Generation of Amorphous Solid Dispersions (ASDs) of Hydrochlorothiazide and Simvastatin., Journal of pharmaceutical sciences, 2023, pS0022-3549(23)00064-3 , Journal Article, PUBLISHED  DOI
  

Page 1 of 18
Test, Test, 2021, Report, PUBLISHED
Healy, A.M., Parojčić, J., Srcic, S., Juppo, A., Andrews, G., McSweeney, N, Glennon, B., Lu trik, M, Jones, I. Milne, J. Corrigan, B. Kinahan, M., Tully, R. , Linking industry and academia in teaching pharmaceutical development and manufacture (LIAT-Ph), European Industrial Pharmacy, 21, 2014, p9 - 10, Journal Article, PUBLISHED
Healy, A.M., Linking Industry and Academe. A case study, FORUM, Spring , 2014, p38-, Journal Article, PUBLISHED
F Tewes, L Tajber, C Ehrhardt, AM Healy, Formulation of colistin-ambroxol microparticles for passive targeting of lung infections, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/11/2011, 13, (S2), 2011, ppM1046 , Meeting Abstract, PUBLISHED
Crean, A.M., Healy, A.M., Changing concepts for 21st Century Drug Product Manufacturing, UK and Ireland Controlled Release Society (UKICRS) Newsletter , 2011, - 4-5, Miscellaneous, PUBLISHED
Paluch, K.J., Tajber, L., Corrigan, O.I., Healy, A.M., Solid state characterisation of novel active pharmaceutical ingredients: co-crystal of (R,S) salbutamol mono-adipate and (R,S) salbutamol hemisuccinate, Solid State Pharmaceutical Cluster Meeting, Limerick, 2010, 2010, Poster, PUBLISHED
Paluch K., Tajber L., Healy A.M., Corrigan O. , Impact of solvent variable on chlorothiazide and chlorothiazide sodium physico-chemical properties, processed by spray drying, All Ireland Schools of Pharmacy 31st Research Seminar, Dublin, 2009, 2009, Meeting Abstract, PRESENTED
Paluch K, Tajber L, Corrigan OI, Healy AM, An investigation of the effect of spray drying from different solvents on the physicochemical properties of chlorothiazide and chlorothiazide sodium, IRCSET Symposium Innovation fuelling the Smart Society, Dublin, 2009, 2009, Poster, PRESENTED
Paluch, K., Tajber, L., Healy, A.M. and Corrigan, O.I., Solid-state characteristics of spray dried chlorothiazide, chlorothiazide-PVP composites, sodium chlorothiazide and sodium chlorothiazide-PVP composites, All Ireland Schools of Pharmacy 30th Research Seminar, Cork, 2008, 2008, Meeting Abstract, PRESENTED
D'Arcy, D.M., Corrigan, O.I. and Healy, A.M., Dissolution modelling of off-centre compacts in the paddle dissolution apparatus, Schools of Pharmacy Research Seminar, Trinity College Dublin, 21st to 22nd March, 2005, pp33 (abstract) , Conference Paper, PUBLISHED

  


Page 1 of 2
Award Date
Special Visiting Researcher Fellowship - awarded by CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil) 2014
Fellowship of Trinity College Dublin 2010
Mendell Award for Scientific Excellence (at the 13th International Conference on Pharmaceutical Technology, Strasbourg, France) 1994
Pharmaceutical Society of Ireland Gold Medal 1989
Jim Hegarty Memorial Prize in Pharmaceutical Chemistry 1989
University of Dublin, Trinity College Non-Foundation Scholarship 1987
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2016
Pharma Industry Awards, Pharma Research Centre of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015
Pharma Industry Awards, Research & Development Achievement Award - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2015
Pharma Industry Awards, Partnership Alliance of the Year - to the Synthesis and Solid State Pharmaceutical Centre (SSPC) [Co-PI and Drug Product Formulation and Manufacture Strand Leader] 2014