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Dr. Fabio Boylan

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW
      
Profile Photo

Dr. Fabio Boylan

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Born in Rio de Janeiro, Brazil, in 15 of February of 1972. Fabio Boylan studied Pharmacy at Rio de Janeiro Federal University, in Rio de Janeiro, Brazil. From February 1996 to February 1998, he was Lecturer at the Department of Pharmacognosy, Faculdade de Farmacia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. His Master project "Phylogenetic Trends within Lamiiflorae" was sponsored by CNPq, a Brazilian Governmental Agency for 1.5 years and he got the degree after being evaluated by Dr. Otto Richard Gottlieb. His Ph.D. project "Chemical and Pharmacological Studies on Raphiodon echinus and Marsypianthes chamaedrys" was sponsored by CAPES, another Brazilian Governmental Agency. In several years he was awarded with grants from FAPERJ (Rio de Janeiro Research Supporting Agency) and FINEP in 2003 when he had the opportunity to chair the XII Italian-Latin-American Conference on Ethnomedicine. Also in 2003 he was awarded with a special grant from CNPq due to his scientific collaboration to the Brazilian Science. Fabio stepped up as a senior lecturer at the Faculty of Pharmacy, Federal University of Rio de Janeiro in 1998. In 2006, he started his sabbatical year in the School of Pharmacy and Pharmaceutical Sciences, TCD, where he further served as a research coordinator from 2007-2008 and now is a full time lecturer in Pharmacognosy. He acts an ad hoc reviewer for the following scientific journals: Brazilian Journal of Pharmacognosy, Brazilian Journal of Medicinal Plants, Brazilian Journal of Microbiology, Brazilian Journal of Pharmaceutical Sciences, Phytochemistry, Iheringia Zoologia (Section Botany), Phytotherapy Research, Current Medicinal Chemistry, African Journal of Pharmacology and Pharmaceutical Sciences, Molecules, Frontiers in Pharmacology, Antioxidants, Journal of Chromatography, among others.
  Antiinflammatory drugs   Biochemistry, metabolism   Chemistry of drug metabolism   Chemistry of drug receptor interactions   Development of drugs for malaria, Cancer and inflammatory diseases   Drug development   Drug discovery   Herbal medicine   Medicinal Chemistry   Medicinal plants   Microencapsulation methodologies   Molecular markers and recognition   Molecular systematics   Organic chemistry   Pharmaceutical products   Pharmacognosy   Pharmacological Sciences   Phytochemical and pharmacological evaluations of native and foreign plants   Phytomedicines   Plant and algal cell monocultures   Plant Biochemistry   Plant biology   Plant systematics   Plant tissue culture   Secondary plant metabolism   Traditional and Indigenous health systems in developing countries
Project Title
 Orbignya speciosa (Arecacea) as a potencial source of novel therapeutic agents: from traditional medicine information to the pharmacological evaluation of its chemical constituents.
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Summary
The aim of this project is to check the validity of the ethnopharmacological information for Orbignya speciosa in folk medicine. This plant is used, among other purposes, for the treatment of leukaemia and inflammatory conditions. Using modern techniques of isolation and purification of natural products and up-to-date spectroscopy techniques we aim to isolate the constituents responsible for such activities. It is also intended to test the activity for the extracts and isolates using in vivo (mice) and in vitro (cell culture) methodologies, allied to techniques in molecular pharmacology: DNA-fragmentation, electrophoresis, zymography, western-blot, apoptosis studies (flow cytometry), microscopy (SEM) among others.
Project Title
 Chemical and pharmacological studies on Jambu and Piquia, two medicinal plants from the Amazon Region: development of new health products with nutraceutical and medicinal properties.
From
2021
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Summary
Acmella oleracea (Jambu) and Caryocar villosum (Piquiá) are two edible plants from the Amazon Region in Brazil. They are part of the local cuisine but also used as medicines to treat cancer. Metabolomic analysis will be employed for the study of the full chemical composition of these two species, using liquid chromatography coupled to mass spectrometry. Isolation of compounds for pharmacological assays will be performed by the use of High-Speed Counter Current Chromatography. Appropriate synthetic strategies will be used to allow for the preparation of large enough quantities of material to be assayed pharmacologically. The pharmacological activity for these two species will be also be assessed using Zebrafish methodology, and specifically the anticancer activity will be determined in cell culture using prostate, breast, intestine and lung cancer cell lines. These four cancers represent the highest incidence of mortality by cancer in Ireland. After standardisation of both chemistry and pharmacology, we envisage to prepare a formulation using modern technology for the development of a food supplement, potentially to be used as chemopreventative. As a long-term goal, we will be setting the basis for the development of a new medicine to treat symptoms associated with cancer.
Project Title
 Chemical and Pharmacological studies on Medicinal Plants from Kazakh Flora
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Summary
Continue the research developed in conjunction with the Republic of Kazakhstan, in the Kazakh National Medical University, specifically in the area of Natural Products aiming to help them to validate their indigenous knowledge and to try and build their own identity in terms of pharmaceutical natural products to enter in their own pharmacopoeia. So using similar approach to the ethnopharmacological knowledge of their plants, the aim is the validation of chemical and pharmacological properties of endemic plants allowing for their inclusion in the National Pharmacopoeia.
Project Title
 Investigation on the anti-inflammatory properties of selected Saudi Medicinal Plants and correlation of their activity with their chemistry
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Summary
People of Saudi Arabia and the Arabian Peninsula, in general, have been using medicinal plants to heal various routine maladies and chronic diseases including skin-related diseases, rheumatism, bone fracture, asthma, diabetes, and eye and ear problems. This unique relationship with the flora continues to this day as people still rely heavily on folklore and traditional medicine to meet their healthcare needs despite of the presence of modern hospitals and well-trained medical staff. However, these traditional practices and folklore, don't specifically present a rational and defined picture of such plants, often using many terms indiscriminately and mixing or distortion of many facts. Often the traditional medicine presents an abstract explanation and consists of imaginative information that can be misleading. Hence the need of a scientific study to evaluate those claims. In this study five medicinal plants widely used in Saudi Arabia as an analgesic and for inflammatory diseases are selected and being studied in order to assess whether the pharmacological activities that have been reported for them is in fact justifiable. The selection criteria for the plants to be studied was based on their ethnopharmacology, and their availabilities. The main aim of this study is to provide the scientific evidence for the reputed efficacy of the Saudi traditional medicinal plants Artemisia judaica, Pistacia falcata Capparis cartilaginea, Lavandula dentata, and Lavandula pubescens, in the maintenance of inflammatory conditions as possessing analgesic and anti-inflammatory activities. This study will also examine the volatile composition of two Lavandula species (dentata, and Lavandula pubescens) collected monthly for one year in order evaluate the chemical variation and establish the best time for collection for medicinal purposes and drug development. The specific objectives are: 1. To investigate extracts from A. judaica, P. falcata C. cartilaginea, L. dentata, and L. pubescens for anti-inflammatory and antinociceptive activities. 2. To isolate, purify and identify bioactive compounds from A. judaica, P. falcata C. cartilaginea, L. dentata, and L. pubescens. 3. To prepare Nano-formulations containing the plant extracts. 4. To evaluate the antinociceptive and anti-inflammatory activities of the plant extracts and isolates through formalin-induced, acetic acid-induced and hot plate models. 5. To carry out Multivariate analysis in order to characterize and compare the phytochemical constituents from L. dentata, and L. pubescens samples collected monthly. This study may be of great help for chemotaxonomic purposes, the interpretation of medicinal properties and for quality assessment of herbal supplements containing Lavandula leaves. 3. Research Questions. The main question for this research is 'Do Artemisia Judaica, Pistacia falcata Capparis cartilaginea, Lavandula dentata, and Lavandula pubescens have anti-inflammatory and antinociceptive activities? These questions are further divided into following questions; · What are the compounds responsible for the biological activities? · How effective are these natural compounds in curing the symptoms inflammatory diseases? This study will also answer the questions: · What are the major phytochemical differences between L. dentata and L. Pubescence? · Which compounds are essential for anti-inflammatory activity?
Project Title
 The scents of St. Stephen's Green: would a Dublin city centre park be hiding a chemical treasure?
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Summary
St. Stephen"s Green park houses over 100 species of plants belonging to over 20 different botanical families. This project proposes the investigation of the essential oil (EO) constituents of all plants growing in the park using two different methodologies - microwave-assisted extraction and headspace. The oil composition will be analysed via gas chromatography coupled with mass spectroscopy. In the event of unknown chemical compounds, their structures will be confirmed by means of synthesis. EOs and EO constituents will be assayed against a panel of normal and cancer cell lines. The potential mechanism of their anticancer activity will be investigated for the EOs and EO constituents using viability and proliferative cell assays, flow cytometry, ELISA and immunoblotting. The best candidates from those with the highest anticancer activity will be formulated using reverse micellar and silver nanoparticle production. The resultant successful nanoformulations will be fully characterised, and their effect will be evaluated once again in vitro

Details Date
Committee for the Academic Council of King Saud University (KSU) to assess the research of Dr. Abdullah Al-Hossaini (KSU# 3618), who has applied for promotion to the status of Associate Professor in the Department of Pharmaceutical Chemistry in the College of Pharmacy. 2023
Evaluator for the Science Fund of the Republic of Serbia 2013
Reviewer of Scientific Journals of very High Impact Factor including Phytochemistry, Phytotherapy Research, Journal of Natural Products, Planta Medica, Plants, Molecules, Plos One, Pharmaceutics, Pharmaceuticals, Antioxidants, Biomedicine and Therapeutics, Frontiers in Pharmacology, Journal of Ethnopharmcology, Brazilian Journal of Pharmacognosy, Journal of Chromatography. since 2000
Head of the Scientific Committee of the 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), responsible for abstract submission and selection of 55 oral presentations out of 176 submissions. July 2023
Associate Editor for Frontiers in Pharmacology 2021
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Fluent Basic Medium
Italian Fluent Medium Medium
Portuguese Fluent Fluent Fluent
Spanish Fluent Medium Medium
Details Date From Date To
Phytochemical Society of North America 1992
Brazilian Society of Pharmacognosy 2000
GA - Society for Medicinal Plant and Natural Product Research 2022
Mladenovic Marko Z, Ristic Milenko N, Bogdanovic Andrija I, Ristic Novica R, Boylan Fabi, Radulovic Niko S, Wax Composition of Serbian Dianthus spp. (Caryophyllaceae): Identification of New Metabolites and Chemotaxonomic Implications, PLANTS-BASEL, 12, (11), 2023, Journal Article, PUBLISHED  DOI
Silveira Damari, Boylan Fabio, Medicinal Plants: Advances in Phytochemistry and Ethnobotany, PLANTS-BASEL, 12, (8), 2023, Journal Article, PUBLISHED  DOI
Fernandes Felipe Hugo Alenca, Soares Sabrina da Silv, Bekbolatova Elmir, Boylan Fabio, Salgado Herida Regina Nune, Pharmacological, toxicological and phytochemical analysis of Spondias dulcis parkinson, NATURAL PRODUCT RESEARCH, 38, (6), 2024, p10149 - 1053, Journal Article, PUBLISHED  DOI
Radulovic Niko S, Mladenovic Marko Z, Dekic Milan S, Boylan Fabio, Synthesis of Small Libraries of Natural Products: Part II: Identification of a New Natural Product from the Essential Oil of Pleurospermum austriacum (L.) Hoffm. (Apiaceae), MOLECULES, 28, (12), 2023, Journal Article, PUBLISHED  DOI
MENSOR, L. L. ; MENEZES, F. S. ; LEITÃO, Gilda Guimarães ; REIS, A. S. ; SANTOS, T. C. ; COUBE, C. S. ; LEITÃO, Suzana Guimarães , Screening of Brazilian Plant Extracts for Antioxidant Activity by the Use of DPPH Free Radical Method, Phytotherapy Research, 15, (2), 2001, p127 - 130, Journal Article, PUBLISHED  DOI
SILVA, Carmelita G ; HERDEIRO, R S ; MATHIAS, C J ; PANEK, Anita Dolly ; SILVEIRA, Cristiane Silva ; RODRIGUES, Verônica Pinto ; RENNÓ, Magdalena Nascimento ; FALCÃO, Deborah Quintanilha ; CERQUEIRA, Débora Malta ; MINTO, Andréa Barreto Mattos ; NOGUEIRA, Fábio Luis Pereira ; QUARESMA, Carla Holandino ; SILVA, Joaquim Fernando Mendes da ; MENEZES, F. S. ; ELEUTHERIO, Elis Cristina de Araújo, Evaluation of Antioxidant Activity of Brazilian Plants, Pharmacological Research, 52, (3), 2005, p229 - 233, Journal Article, PUBLISHED  DOI
MATHEUS, Maria Eline ; BERRONDO, Luciane Fátima ; VIEITAS, Eniana Campolina ; MENEZES, F. S. ; FERNANDES, Patrícia Dias , Evaluation of the Antinociceptive Properties from Brillantaisia palisotii Lindau Stems Extracts, Journal of Ethnopharmacology, 102, (3), 2005, p377 - 381, Journal Article, PUBLISHED  DOI
Amado, NG; Cerqueira, DM; Menezes, FS; Silva, JFM; Neto, V.M.; Abreu, J.G., Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes B-catenin cellular localization, Anti Cancer Drugs, 20, (7), 2009, p543 - 552, Journal Article, PUBLISHED  DOI
de Sousa, VP, Crean, J, Borges, VRD, Rodrigues, CR, Tajber, L, Boylan, F, Cabral, LM, Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia, INTERNATIONAL JOURNAL OF NANOMEDICINE, 8, 2013, p3129-3139 , Journal Article, PUBLISHED  DOI
C.G. Silva, R. Raulino, D.M. Cerqueira, M.D. Pereira, A.D. Panek, J.F.M. Silva, E.C.A. Eleutherio, F.S. Menezes., In vitro and in vivo determination of antioxidant activity and mode ofaction of isoquercitrin and Hyptis fasciculata, Phytomedicine, 2009, Journal Article, PUBLISHED  DOI
  

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Award Date
Cum Laude Diploma 1992
Global Relations Certificate of Excellence 2015-2016
My research focuses on discovering the scientific basis of natural medicines used by disadvantaged communities and evaluating the chemistry of Bioactive Volatile Organic Compounds (BVOCs). I also investigate harmful effects of natural medicines and aim to validate the use of medicinal plants in different countries. For future research, I plan to study medicinal plants from Saudi Arabia and Brazil as well as continue research in the Republic of Kazakhstan. Additionally, I will be investigating the essential oil constituents of plants in St. Stephen's Green Park to understand their anticancer and anti-inflammatory activities. I have published 125 research papers with an average IF of 4.6 and have an international impact in the Pharmacy and Natural Products field. My work has been widely published (over 100 papers) and cited (h index of 31, Google Scholar). I have an illustrious record of publications and a high research interest score. My most impactful publication relates to COVID-19 and has received significant attention (over 330K views and over 16K downloads). According to the Researchgate database, my research interest score (2,654) is higher than 98% of scientists in Pharmacy, I have authored a total of 125 publications that have had 33,428 reads and 4,828 citations. My Google Scholar i10 index is 67 with an upward trajectory in terms of publication citation, with a peak in 2021 due to my most downloaded publication from 2020 in Frontiers in Pharmacology related to COVID-19 - 334,700 views and 16,464 downloads. These achievements have resulted from intensive supervision of graduate students and continuous dedication to this field for over 25 years. The key research directions of my research on essential oils and ethnopharmacology include: 1. Novel Therapeutic Applications: Research on bioactive compounds of essential oils and traditional medicinal plants for the development of new pharmaceuticals to treat diseases like cancer and inflammation. 2. Antimicrobial Resistance (AMR): Exploring essential oils and ethnopharmacological remedies as alternatives to conventional antibiotics to address the global challenge of antimicrobial resistance. 3. Safety and Efficacy Validation: Conducting rigorous pre-clinical assessments and toxicology studies to validate the safety and efficacy of essential oils and traditional medicines aiming their integration into mainstream medicine. 4. Sustainable and Ethical Sourcing: Investigating sustainable cultivation practices for medicinal plants used for the production of essential oils and as ethnopharmacological sources of raw material to protect biodiversity and ensure long-term availability. 5. Interdisciplinary Collaboration and International Collaboration: Collaborating with fields such as molecular biology, chemistry, pharmacology, and environmental science to lead to groundbreaking discoveries and have a global health impact. 6. Innovation in Delivery Systems: Developing new delivery systems for essential oils to improve therapeutic efficacy aiming future patient compliance. 7. Educational and Community Engagement: Disseminating research through publications, conferences, and workshops to educate the scientific community and the public about the safe use of essential oils and traditional medicines. In conclusion, to support my application for promotion, it's crucial to emphasize the relevance, impact, and innovation of my research in essential oils and ethnopharmacology, highlighting the translation of traditional knowledge into modern applications. The Figure below gives a glimpse of how my research aligns with a few TCD research themes and showcases the importance of my research output and the formation of human resources in the field.