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Tá Gaeilge agam.       
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Dr. Deirdre D'Arcy

Associate Professor (Pharmacy)
25/6/7 WESTLAND ROW


Deirdre D'Arcy (M Pharm, PhD, MPSI); Deirdre is a qualified pharmacist (1999) and holds post graduate diplomas in both Clinical Pharmacy and Quality Improvement, and a PhD in Pharmaceutical Technology. She is a registered pharmacist with the Pharmaceutical Society of Ireland and the General Pharmaceutical Council (UK). After spending 3 years training as a specialist clinical pharmacist, during which time she developed an interest in Clinical Pharmacokinetics, Deirdre spent some time in community pharmacy. Following this she undertook a PhD in Pharmaceutical Technology, exploring methods to mathematically simulate pharmaceutical processes. Concurrently, she undertook a diploma in quality improvement and also worked part-time as a community pharmacist. She embarked on her academic career in 2005, in the School of Pharmacy and Pharmaceutical Sciences (SOPPS) TCD. This unique combination and breadth of experiences, and her professional status as a qualified, registered pharmacist, has equipped Deirdre with a distinctly valuable perspective on the interplay between clinical aspects of pharmacy practice and the use of pharmaceutical technology in medicines development. This extensive background has facilitated a range of teaching roles, didactic and experiential, at undergraduate and postgraduate level. Furthermore, it has enabled her to develop and lead the novel role of Integration Co-ordinator for the new Pharmacy (Integrated) Programme, promoting integrative teaching and learning between core science, clinical, and experiential learning; and the embedding of graduate attributes and competences within the curriculum. Context for Integration Co-ordinator role: The new Pharmacy (Integrated) Programme (first intake 2015) results from a change in the national pharmacy education requirements of the Pharmaceutical Society of Ireland. A minimum of 12 months experiential placement-based learning, which used to take place post-graduation and before pharmacist registration, is now integrated within the core 5-year academic programme. Thus the new Pharmacy (Integrated) programme represents a mammoth shift in educational delivery by the SOPPS, with significantly different, advanced programme learning outcomes. Formal, structured integration of campus-based and experiential placement-based learning was thus novel to SOPPS pharmacy education. Furthermore, modern pedagogical perspectives on education in all health care settings have a focus on the integration of core science learning with more applied therapeutics/clinical learning content. Deirdre has been involved in 3 International EU-funded educational projects (Institutional lead on one of these), prompting innovations in Technology Enhanced Learning and assessment methodologies. These roles and innovations are fully aligned with the recommendations of the Trinity Education Project. Deirdre is also an active researcher, again supported by her unique combined experience of Patient-Facing practice and Pharmaceutical Technology. Current research includes 2 main strands: 1: Application of computational modelling and simulation techniques in pharmacy and pharmaceutical technology to improve processes and practice, including pharmacokinetic and dissolution modelling 2: Clinically relevant drug development and delivery to special populations. She has been PI on 2 clinical trials, and is lead PI of the Clinical Pharmacokinetics research group (http://pharmacy.tcd.ie/research/clinical_pharm.php). She is involved in several international collaborations, with relevance to access to medicines and personalised medicines. Research outputs have resulted in peer reviewed publications, invited presentations at national and international level, partaking in national policy submission groups, and tangible outputs in the form of changes to medicines dosing policy and software development. Research funding sources include IRCSET, the Meath Foundation, Pharmaceutical Industry.
  ANTIBIOTICS   CLINICAL PHARMACOKINETICS   COMPUTATIONAL FLUID DYNAMICS (CFD)   COMPUTER MODELING AND SIMULATION   DISSOLUTION   DISSOLUTION MECHANISMS   DISSOLUTION RATES   DISSOLUTION TESTING   Dosage Forms   Drug Delivery Systems   FORMULATIONS   Methods of Drug Delivery   PHARMACODYNAMICS   Pharmacokinetics   Pharmacotherapy   PK/PD   STERILE
 An investigation to determine an appropriate teicoplanin dosage regimen for the treatment of Gram-positive infection in patients with haematological malignancy.
 Simulation of dissolution rate profiles of pharmaceutical systems
 A clinical pharmacokinetic evaluation of amphotericin B lipid complex in critically ill patients
 Effect of hydrodynamics in the USP apparatus 4 on dissolution/drug release rates

Details Date
Member of accreditation committee for the Seasonal Influenza Vaccination Programme for Pharmacists 2011/12 -2012/13
Irish Institute of Pharmacy: Member of Peer Review Panel for Assessment of CPD Programmes December 2014 to present
Irish Institute of Pharmacy (IIOP): Member of working group for IIOP submission to National Maternity Strategy 2015
Committee for Women's Health group, United Kingdom Clinical Pharmacy Association 2016 to present
Regular peer-reviewer for relevant scientific and clinical journal (13) 2009 to present
External examiner -PhD thesis - University of Barcelona 2017
External examiner- MSc thesis - University of Western Cape, South Africa 2016
Adjudicator at Hospital Pharmacy Association of Ireland (HPAI) annual meeting -poster competition 2011
Member of the Accreditation Working Group for the Five-Year Integrated Pharmacy Programme 2014-present
Institutional Lead -PQPharm (Postgraduate Qualification in Pharmacy) International educational project funded under the the EU Tempus Programme 2009-2013
Language Skill Reading Skill Writing Skill Speaking
English Fluent Fluent Fluent
French Medium Basic Medium
Irish Fluent Fluent Fluent
Details Date From Date To
Pharmaceutical Society of Ireland 2002 Present
United Kingdom Clinical Pharmacy Association 2009 Present
General Pharmaceutical Council (GPhC-UK) 1999 Present
Byrne CJ, Roberts JA, McWhinney B, Ryder SA, Fennell JP, O'Byrne P, Deasy E, Egan S, Desmond R, Enright H, D'Arcy DM, McHugh J, Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy, Clinical Microbiology and Infection, 23, (9), 2017, p674.e7-674.e13 , Notes: [PMID: 28267636], Journal Article, PUBLISHED  TARA - Full Text  DOI  Handle
Byrne CJ, Parton T, McWhinney B, Fennell JP, O'Byrne P, Deasy E, Egan S, Enright H, Desmond R, Ryder SA, D'Arcy DM, McHugh J, Roberts JA, Population pharmacokinetics of total and unbound teicoplanin concentrations and dosing simulations in patients with haematological malignancy, Journal of Antimicrobial Chemotherapy, 2017, Journal Article, PUBLISHED  DOI  URL
Anne Marie Liddy, Gavin McLaughlin, Susanne Schmitz, Deirdre D'Arcy, Michael Barry, The Pharmacokinetic Interaction between Ivacaftor and Ritonavir in Healthy Volunteers, British Journal of Clinical Pharmacology, 83, (10), 2017, p2235 - 2241, Journal Article, PUBLISHED  DOI
Byrne CJ, Roberts JA, McWhinney B, Fennell JP, O'Byrne P, Deasy E, Egan S, Desmond R, Enright H, Ryder SA, D'Arcy DM, McHugh J, Variability in trough total and unbound teicoplanin concentrations and achievement of therapeutic drug monitoring targets in adult patients with haematological malignancy, Antimicrobial Agents and Chemotherapy, 61, (6), 2017, pe02466-16 , Notes: [PMID: 28320714], Journal Article, PUBLISHED  TARA - Full Text  DOI
David McDonnell,D. M. D'Arcy, L.J. Crane, Brendan Redmond, A Mathematical Analysis of Drug Dissolution in the USP Flow Through Apparatus, Heat and Mass Transfer, 2017, Journal Article, ACCEPTED  DOI
Munshi R, O'Keeffe H, Coyle M, Deasy E, Fitzpatrick GJ, Lavin PJ, Donnelly M, D'Arcy DM, Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous haemodiafiltration (CVVHDF) on different anticoagulant modalities. , Intensive Care Medicine Experimental, European Society of Intensive Care Medicine 30th Annual Congress, Vienna, Austria, 23rd- 27th September, edited by . , 5 (Suppl 2), (44), 2017, Meeting Abstract, PUBLISHED  URL
O'Keeffe, Hannah Marie, Munshi, Reema Mohammad, Coyle, Mary, Deasy, Evelyn, Donnelly, Maria B, Fitzpatrick, Gerard J, Lavin, Peter J., D'Arcy, Deirdre M, Exploring population Pharmacokinetics of Vancomycin While Using Different Anticoagulant Modalities during Continuous Venovenous Haemodiafiltration (CVVHDF), Journal of the American Society of Nephrology, American Society of Nephrology Kidney Week, New Orleans, LA, USA, Oct 31-Nov 5 2017, 28, (October), 2017, Meeting Abstract, PUBLISHED
William H. Marks, Lydia Drumright, Nigel K. H. Slater and Deirdre M. D'Arcy, Novel Imaging Platform for Predicting Efficacy of Nipple Shield Delivery System Designs via High-Speed Photography, 14th IEEE International Symposium on Biomedical Imaging, Melbourne, Australia, April 2017, 2017, Oral Presentation, PRESENTED  TARA - Full Text
William H. Marks, Lydia N. Drumright, Nigel K.H. Slater and Deirdre M. D'Arcy , Using CFD Simulations of USP4 Flow Through Cell to Visualize Fluid Movement through a Novel Drug Delivery System, FIP PSWC 2017 6th pharmaceutical Sciences World Congress, Stockholm Sweden, May 22nd-24th, 2017, Poster, PRESENTED
William H. Marks, Deirdre M. D'Arcy, Nigel K.H. Slater, Lydia N. Drumright, Novel Drug Release Test Using USP4 Flow Through Cell for Nipple Shield Delivery System, 8th APS International PharmSci Conference 2017, University of Hertfordshire, UK, 5th-7th September, 2017, Poster, PRESENTED
  

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Deirdre M D'Arcy, Simulation and Comparison of Hydrodynamics in Compendial Dissolution Apparatuses Using Computational Fluid Dynamics (CFD), USP Workshop on Computer Modeling - In vitro and In vivo Studies, USP Meetings Center, Rockville, MD USA, October 23-25, 2017, 2017, US Pharmacopeial Convention, Invited Talk, ACCEPTED
Munshi R, O'Keeffe H, Coyle M, Deasy E, Lavin P, Donnelly M, D'Arcy DM., Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration (CVVHDF) on different anticoagulant modalities. , 39th All Ireland Schools of Pharmacy Conference, Cork, Ireland, April 24-25, 2017, 2017, Oral Presentation, PRESENTED
Byrne CJ, Roberts JA, McWhinney B, Ryder SA, Fennell JP, O'Byrne P, Deasy E, Egan S, Enright H, D'Arcy DM, McHugh J, Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy, Trinity College Dublin: Faculty of Health Sciences Research Day, Trinity College Dublin, Ireland, 15 September 2016, 2016, Poster, PRESENTED
Byrne CJ, McWhinney B, Roberts JA, Fennell JP, Egan S, O'Byrne P, Deasy E, Enright H, Ryder SA, McHugh J, D'Arcy DM, Pharmacokinetic analysis of teicoplanin in patients with haematological malignancy, 37th All Ireland Schools of Pharmacy Research Seminar, Belfast, Northern Ireland, 30-31 March 2015, 2015, Poster, PRESENTED
Ryder SA, D'Arcy DM, McHugh J, 'A prospective, single-centre, cohort study to determine the pharmacokinetic and pharmacodynamic parameters of teicoplanin in adult patients with haematological malignancy', Dublin, Ireland, 2014, -, Notes: [Clinical Trial protocol authorised by Irish Medicines Board January 2014], Protocol or guideline, APPROVED
Byrne C, McHugh J, Egan S, Fennell JP, Enright H, O'Byrne P, Deasy E, Ryder SA, D'Arcy DM, Teicoplanin dosage in haematological malignancy: Is it time to reconsider?, 36th All Ireland Schools of Pharmacy Research Seminar, Dublin, Ireland, 14-15 April 2014, 2014, Oral Presentation, PRESENTED
Catherine J. Byrne, Sheila A. Ryder, Jerome P. Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Helen Enright, Deirdre M. D'Arcy, Johnny McHugh, Teicoplanin dosing in haematological malignancy - is it time to reconsider?, TBSI annual symposium, Dublin, May 2014, 2014, Oral Presentation, PRESENTED
Byrne C, McHugh J, Egan S, Fennell J, Enright H, O'Byrne P, Deasy E, Ryder SA, D'Arcy DM, Teicoplanin dosage in adult patients with haematological malignancy: Can we improve on current practices?, Irish Antimicrobial Pharmacists Group, Dublin, Ireland, 22 October 2014, 2014, Oral Presentation, PRESENTED
Byrne C, Egan S, D'Arcy DM, O'Byrne P, Deasy E, Fennell J, Enright H, McHugh J, Ryder SA, Teicoplanin usage in adult patients with haematological malignancy in the UK and Ireland: Is there scope for improvement?, Tallaght Hospital Research Exhibition, Dublin, Ireland, 20 November 2014, 2014, Poster, PRESENTED
Byrne C, McHugh J, Egan S, Fennell JP, Enright H, O'Byrne P, Deasy E, Ryder SA, D'Arcy DM, Teicoplanin dosing in haematological malignancy - is it time to reconsider?, Tallaght Hospital Pharmacy Department Education Meeting, Dublin, Ireland, 26 September 2013, 2013, Oral Presentation, PRESENTED

  

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Award Date
Sotax Award for Dissolution Innovation September 2010
Tocher Medal from Robert Gordon University 1st place final year pharmacy exams July 1998
My research interests can be presented as 2 main themes: 1. Application of computational modelling and simulation techniques in pharmacy and pharmaceutical technology, to improve processes and practice. I have used a number of different computational modelling and simulation approaches and packages in 2 main contexts: A) Clinical Pharmacokinetics: Clinical pharmacokinetics (PK) involves modelling the time course of a medicine in the body, in order to understand the medicine's journey through the body. This then facilitates design of optimal dosing regimens (dose and interval) to achieve therapeutic goals. My clinical PK work to date has focussed on optimising antibiotic use. I am the academic PI for the Clinical Pharmacokinetics Research Group, a collaboration with Tallaght Hospital. I have worked with both the Intensive Care Unit and Haematology Departments, and the hospital Pharmacy Department. B) Pharmaceutical Drug Development: My modelling and simulation in Pharmaceutical Drug Development has focussed on dissolution modelling. Dissolution testing involves determination of the rate and extent of drug dissolution and release from any dosage form. It is an essential component of early stage drug formulation development, and also quality control (QC). Of global research interest are i) the development of dissolution testing methodologies which best reflect the in vivo environment for drug release, to support early stage formulation development, and ii) understanding sources of variability in dissolution testing to minimise risk of failure to meet specifications in QC testing of manufactured batches. I have developed significant expertise in computational fluid dynamics (CFD) modelling of fluid dynamics within different dissolution test apparatuses, assisting determination of sources of variability from a QC perspective and also in vivo relevant dissolution method development. Furthermore, I have co-developed a dissolution simulation package with Dr. Tim Persoons (Dept. of Mechanical and Manufacturing Engineering, TCD). We have accompanied this simulation package with a novel investigational tool for visualisation of dissolution, based on the principles of shadowgraph imaging. 2. Clinically relevant drug development and delivery to special populations. The dual concepts of access to medicines and personalised medicines are highly relevant in today's global pharmaceutical environment. Based on a combination of my clinical and pharmaceutical technology experience and expertise, my research addresses both of these concepts.Relevant international collaborations include those with Cambridge University and University of Bath, UK, exploring the development of dissolution and drug release testing methodologies which will support drug development for two specific populations: critically ill patients and neonates/infants. My collaboration with Cambridge University focussed on the development of a dissolution testing environment from a nipple shield designed specifically with the aim of drug delivery to neonates while breastfeeding. My collaboration with University of Bath focusses on the development of dissolution testing for lipid-based parenteral formulations, with the dissolution medium representing the characteristics of plasma in critically ill patients. Of topical significance is my collaboration with the National Centre for Pharmacoeconomics and the School of Medicine, TCD, investigating the role of pharmacokinetic "boosting" drugs in reducing dosing (cost) of expensive medicines. Finally I have an ongoing collaboration with Dr. Suzanne McCarthy, in University College Cork. We are investigating the potential for provision of breastfeeding support in a community pharmacy environment. Primarily this focusses on support for medication use (in either baby or mother) during breastfeeding, but with a general health promotion angle also.