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Dr. Andreea Phelan

Research Fellow (Biochemistry)

 petrasan@tcd.ie

 


Research Projects

 A pilot study to characterise resident memory T cells in the skin of hidradenitis suppurativa patients
 
 Targeting dysregulated bioenergetics in the inflamed rheumatoid arthritis joint
 Functional studies on human γδ T cells and their interactions with dendritic cells and B cells
 Characterisation of the stimulatory properties of synthetic α-galactosylceramide for human invariant natural killer T cells

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Representations

Details Date
Oral presentation at the New Horizons in Rheumatology international biennial meeting. Title of the talk: "Targeting cellular metabolism in CD4-stimulated synovial fibroblasts reduces inflammation and joint degradation in rheumatoid arthritis". November 2018
Oral presentation at the annual Irish Society for Immunology meeting. Title of the talk: "Targeting cellular metabolism in CD4-stimulated synovial fibroblasts reduces inflammation and joint degradation in rheumatoid arthritis". August 2018
Oral presentation at an international congress (British Society for Immunology congress). Title of the talk: "Human synovial fibroblasts and CD4 T cells cooperate to promote inflammation in the RA synovial joint". Brighton, UK, December 2017.
Oral presentation at a national meeting (Institute of Molecular Medicine Annual Meeting). Title of the talk: "Human Vγ9Vδ2 T cells induce B cell and DC maturation - applications for cancer immunotherapy". Dublin, November 2014
Oral presentation at a national meeting (Institute of Molecular Medicine Annual Meeting). Title of the talk: "Human Vγ9Vδ2 T cells can selectively promote TH1 or TH2 responses via interactions with dendritic cells or B cells in vitro". November 2013
Oral presentation at a national meeting (School of Medicine Postgraduate research day). Title of the talk: "Reciprocal activating interactions between Vγ9Vδ2 T cells, B cells and dendritic cells". September 2012
Invited talk to the "Rheumatology Seminar Series" held at St. Vincent's University Hospital. Title of the talk: "T cells and synovial fibroblasts cooperate to promote inflammation in the joint". November 2017
Invited talk to the "Immunology Seminar Series" held at St. James's Hospital. Title of the talk: "Functional studies on human γδ T cells and their interactions with dendritic cells and B cells". April 2016

Memberships

Membership of Professional Institutions, Associations, Societies

Details Date From Date To
Member of the Research Ethics Committee in the School of Biochemistry and Immuonology Aug 2019 Present
President of the TBSI Postdoc Society 2021-Present. Vice-president 2019-2021. 2019 Present
Postdoctorate representative on the Executive Committee for School of Biochemistry&Immunology 2018 Present
Cluxton D, Petrasca A, Moran B, Fletcher JM, Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis, Frontiers in Immunology, 10, 2019, p115-, Journal Article, PUBLISHED  TARA - Full Text  DOI
Petrasca A, Melo AM, Breen EP, Doherty DG, Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells, Immunology Letters, 196, 2018, 126-134 , Journal Article, PUBLISHED  DOI  URL
Melo AM, Zhang L, Dockry EF, Petrasca A, Ghnewa YG, Morrissey ME, O'Reilly C, Bruen R, O'Meara A, Lysaght J, Zhu X, Doherty DG, Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells, Frontiers in Immunology, 2018, Journal Article, PUBLISHED  TARA - Full Text
Dunne PJ, Maher CO, Freeley M, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG, CD3ε expression defines functionally-distinct subsets of Vδ1 T cells in patients with HIV infection, Frontiers in Immunology, 2018, Journal Article, PUBLISHED
Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885 , Journal Article, PUBLISHED  DOI
Petrasca A, Doherty DG, Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells, Frontiers in Immunology, 2014, 650-, Journal Article, PUBLISHED  TARA - Full Text  DOI  URL
Kennedy A, Petrasca A, Doherty DG, Hennessy M, Spiers JP, HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or V"9V"2 T lymphocytes., AIDS (London, England), 28, (1), 2014, p131-3 , Journal Article, PUBLISHED  URL
Murphy N, Petrasca A, Murphy NM, Reilly VO, Evans P, Doherty DG, Zhu XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377 , Journal Article, PUBLISHED  URL
  

Andreea Petrasca, Derek G. Doherty, Vδ2 T cells differentially stimulate the production of proinflammatory cytokines by dendritic cells and B cells, Medimond International Proceedings, 15th International Congress of Immunology, Milan, Italy, 22-27 August 2013, edited by Medimond s.r.l. , Monduzzi editore, 2014, pp21 - 24, Conference Paper, PUBLISHED

  

Awards and Honours

Award Date
Travel Bursary for British Society of Immunology Congress December 2014

Research Interests

Description Of Research Interests

I am really passionate about scientific and biomedical research and my background includes immunology, molecular medicine and neuroscience. Specific fields of interest include cell biology,immunology, immunometabolism, translational medicine and oncology.