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Dr. Mary Canavan

Assistant Professor (Biochemistry)

 canavam1@tcd.ie

 

Assistant Professor (Clinical Medicine TBSI)


Biography

My research focuses on understanding the immunological mechanisms which drive the development of autoimmune diseases, such Rheumatoid Arthritis and Inflammatory Bowel Disease. We explore the role of innate and adaptive immunity in the pathogenesis these diseases. By using physiologically relevant ex-vivo models, across multiple disease stages, we aim to identify new biomarkers for disease onset, therapeutic response and disease severity. Finally, we collaborate with several pharmaceutical companies, clinicians, translational scientists and patients to maximise the impact of our work and ensure the successful translation of our findings from bench to bedside.

Research Tags

  Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)   Inflammation   Innate immunology   Rheumatology and rheumatological disorders

Research Projects

 Tissue Specific Immune Memory Mediates Disease Progression and Disease Flare in Rheumatoid Arthritis
 Restoration of Immunological Tolerance in Rheumatoid Arthritis via Metabolic Reprogramming
 Synovial T cell Memory Responses in Rheumatoid Arthritis Disease Progression
 Ongoing Examination of the PD-1 Pathway throughout the Evolution of Rheumatoid Arthritis

Barker BE, Hanlon MM, Marzaioli V, Smith CM, Cunningham CC, Fletcher JM, Veale DJ, Fearon U, Canavan M., The mammalian target of rapamycin contributes to synovial fibroblast pathogenicity in rheumatoid arthritis., Frontiers in medicine, 10, 2023, p1029021 , Journal Article, PUBLISHED  DOI
Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022, Journal Article, PUBLISHED
Floudas A, Smith CM, Tynan O, Neto N, Krishna V, Wade SM, Hanlon M, Cunningham C, Marzaioli V, Canavan M, Fletcher JM, Mullan RH, Cole S, Hao LY, Monaghan MG, Nagpal S, Veale DJ, Fearon U., Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis., Annals of the rheumatic diseases, 2022, pannrheumdis-2021-221761 , Journal Article, PUBLISHED  DOI
Viviana Marzaioli, Mary Canavan, Alex Donnolly, Siobhan Wade, Alexander Fraser, Tim O'Sullivan, Sinead Harney, Arthritis Ireland, Douglas J. Veale, Ursula Fearon, Knowledge of disease, diagnosis, adherence and impact of research in an Irish cohort of patients with inflammatory arthritis, HRB Open Research, 4, 2021, p60 , Journal Article, PUBLISHED  DOI
Canavan M, Marzaioli V, Bhargava V, Nagpal S, Gallagher P, Hurson C, Mullan R, Veale DJ, Fearon U, Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium., Frontiers in immunology, 2021, Journal Article, PUBLISHED  DOI
Hanlon MM, Canavan M, Barker BE, Fearon U., Metabolites as drivers and targets in Rheumatoid Arthritis., Clinical and experimental immunology, 2021, Journal Article, PUBLISHED  DOI
Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021, Journal Article, PUBLISHED  DOI
Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33-, Journal Article, PUBLISHED
Canavan M, Wade SM, Veale DJ, Fearon U, Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al., Annals of the rheumatic diseases, 2020, Journal Article, PUBLISHED  DOI
Foley, C., Floudas, A., Canavan, M., Biniecka, M., MacDermott, E. J., Veale, D. J., Mullan, R. H., Killeen, O. G., Fearon, U., Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome"Associated Arthritis, Arthritis & Rheumatology, 72, (4), 2020, p677-686 , Journal Article, PUBLISHED  DOI
  

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Research Interests

Description Of Research Interests

Interested in immune dysregulation with drives human autoimmune diseases, such as Rheumatoid Arthritis and Inflammatory Bowel Disease. Specifically my research focuses on Dendritic Cells and T cells specifically within the inflamed tissues and explores the contribution of metabolism, maturation and checkpoint inhibitors on their role in disease pathogenesis